UniProtKB - B7Z641 (B7Z641_HUMAN)
Protein
V-type proton ATPase subunit a
Gene
ATP6V0A1
Organism
Homo sapiens (Human)
Status
Functioni
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation
GO - Molecular functioni
- proton transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Hydrogen ion transportUniRule annotation, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit aUniRule annotation |
Gene namesi | Name:ATP6V0A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000033627.14 |
HGNCi | HGNC:865, ATP6V0A1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
- vacuolar proton-transporting V-type ATPase, V0 domain Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 358 – 382 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 402 – 421 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 498 – 519 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 525 – 549 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 590 – 614 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 692 – 715 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 721 – 744 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000033627, Expressed in frontal cortex and 231 other tissues |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000182881 |
HOGENOMi | CLU_005230_0_2_1 |
Family and domain databases
InterProi | View protein in InterPro IPR002490, V-ATPase_116kDa_su IPR026028, V-type_ATPase_116kDa_su_euka |
PANTHERi | PTHR11629, PTHR11629, 2 hits |
Pfami | View protein in Pfam PF01496, V_ATPase_I, 2 hits |
PIRSFi | PIRSF001293, ATP6V0A1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
B7Z641-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK
60 70 80 90 100
FVNEVRRCEE MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEMA
110 120 130 140 150
DPDLLEESSS LLEPSEMGRG TPLRLGFVAG VINRERIPTF ERMLWRVCRG
160 170 180 190 200
NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV KKICEGFRAS
210 220 230 240 250
LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW
260 270 280 290 300
FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH
310 320 330 340 350
SGSTVPSILN RMQTNQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP
360 370 380 390 400
YTIITFPFLF AVMFGDFGHG ILMTLFAVWM VLRESRILSQ KNENEMFSTV
410 420 430 440 450
FSGRYIILLM GVFSMYTGLI YNDCFSKSLN IFGSSWSVRP MFTYNWTEET
460 470 480 490 500
LRGNPVLQLN PALPGVFGGP YPFGIDPIWN IATNKLTFLN SFKMKMSVIL
510 520 530 540 550
GIIHMLFGVS LSLFNHIYFK KPLNIYFGFI PEIIFMTSLF GYLVILIFYK
560 570 580 590 600
WTAYDAHTSE NAPSLLIHFI NMFLFSYPES GYSMLYSGQK GIQCFLVVVA
610 620 630 640 650
LLCVPWMLLF KPLVLRRQYL RRKHLGTLNF GGIRVGNGPT EEDAEIIQHD
660 670 680 690 700
QLSTHSEDAD EFDFGDTMVH QAIHTIEYCL GCISNTASYL RLWALSLAHA
710 720 730 740 750
QLSEVLWTMV IHIGLSVKSL AGGLVLFFFF TAFATLTVAI LLIMEGLSAF
760 770 780
LHALRLHWVE FQNKFYSGTG FKFLPFSFEH IREGKFEE
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ93050 | VPP1_HUMAN | V-type proton ATPase 116 kDa subuni... | ATP6V0A1 ATP6N1, ATP6N1A, VPP1 | 837 | Annotation score: | ||
K7EM24 | K7EM24_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 130 | Annotation score: | ||
K7ERA6 | K7ERA6_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 188 | Annotation score: | ||
K7ENA1 | K7ENA1_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 191 | Annotation score: | ||
K7ERA0 | K7ERA0_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 129 | Annotation score: | ||
F5H1T6 | F5H1T6_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 483 | Annotation score: | ||
K7EPG4 | K7EPG4_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 198 | Annotation score: | ||
B7Z2A9 | B7Z2A9_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 794 | Annotation score: | ||
K7EN36 | K7EN36_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 195 | Annotation score: | ||
K7EQW2 | K7EQW2_HUMAN | V-type proton ATPase subunit a | ATP6V0A1 | 68 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC067852 Genomic DNA No translation available. AC107993 Genomic DNA No translation available. AK299784 mRNA Translation: BAH13127.1 |
Genome annotation databases
Ensembli | ENST00000537728; ENSP00000443991; ENSG00000033627 |
UCSCi | uc010wgk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC067852 Genomic DNA No translation available. AC107993 Genomic DNA No translation available. AK299784 mRNA Translation: BAH13127.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B7Z641 |
PRIDEi | B7Z641 |
ProteomicsDBi | 6742 |
Protocols and materials databases
Antibodypediai | 16938, 97 antibodies |
Genome annotation databases
Ensembli | ENST00000537728; ENSP00000443991; ENSG00000033627 |
UCSCi | uc010wgk.3, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000033627.14 |
HGNCi | HGNC:865, ATP6V0A1 |
OpenTargetsi | ENSG00000033627 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182881 |
HOGENOMi | CLU_005230_0_2_1 |
Miscellaneous databases
ChiTaRSi | ATP6V0A1, human |
Gene expression databases
Bgeei | ENSG00000033627, Expressed in frontal cortex and 231 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002490, V-ATPase_116kDa_su IPR026028, V-type_ATPase_116kDa_su_euka |
PANTHERi | PTHR11629, PTHR11629, 2 hits |
Pfami | View protein in Pfam PF01496, V_ATPase_I, 2 hits |
PIRSFi | PIRSF001293, ATP6V0A1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z641_HUMAN | |
Accessioni | B7Z641Primary (citable) accession number: B7Z641 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | October 7, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |