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UniProtKB - B7Z600 (B7Z600_HUMAN)
Protein
Submitted name:
cDNA FLJ53180, highly similar to Cullin-3
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Biological process | Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ53180, highly similar to Cullin-3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
PTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, Ubl conjugationARBA annotationProteomic databases
PeptideAtlasi | B7Z600 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 165 – 417 | CULLIN_2InterPro annotationAdd BLAST | 253 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 459 – 480 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 464 – 480 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR045093, Cullin IPR016157, Cullin_CS IPR016158, Cullin_homology IPR036317, Cullin_homology_sf IPR001373, Cullin_N IPR019559, Cullin_neddylation_domain IPR016159, Cullin_repeat-like_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11932, PTHR11932, 1 hit |
Pfami | View protein in Pfam PF00888, Cullin, 1 hit PF10557, Cullin_Nedd8, 1 hit |
SMARTi | View protein in SMART SM00182, CULLIN, 1 hit SM00884, Cullin_Nedd8, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF74788, SSF74788, 1 hit SSF75632, SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS01256, CULLIN_1, 1 hit PS50069, CULLIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B7Z600-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESQKFLAEN SASVYIKKVE ARINEEIERV MHCLDKSTEE PIVKVVEREL
60 70 80 90 100
ISKHMKTIVE MENSGLVHML KNGKTEDLGC MYKLFSRVPN GLKTMCECMS
110 120 130 140 150
SYLREQGKAL VSEEGEGKNP VDYIQGLLDL KSRFDRFLLE SFNNDRLFKQ
160 170 180 190 200
TIAGDFEYFL NLNSRSPEYL SLFIDDKLKK GVKGLTEQEV ETILDKAMVL
210 220 230 240 250
FRFMQEKDVF ERYYKQHLAR RLLTNKSVSD DSEKNMISKL KTECGCQFTS
260 270 280 290 300
KLEGMFRDMS ISNTTMDEFR QHLQATGVSL GGVDLTVRVL TTGYWPTQSA
310 320 330 340 350
TPKCNIPPAP RHAFEIFRRF YLAKHSGRQL TLQHHMGSAD LNATFYGPIK
360 370 380 390 400
KEDGSEVGVG GAQVTGSNTR KHILQVSTFQ MTILMLFNNR EKYTFEEIQQ
410 420 430 440 450
ETDIPERELV RALQSLACGK PTQRVLTKEP KSKEIENGHI FTVNDQFTSK
460 470 480 490 500
LHRVKIQTVA AKQGESDPER KETRQKVDDD RKHEIEAAIV RIMKSRKKMQ
510 520 530 540 550
HNVLVAEVTQ QLKARFLPSP VVIKKRIEGL IEREYLARTP EDRKVYTYVA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299644 mRNA Translation: BAH13086.1 |
RefSeqi | NP_001244126.1, NM_001257197.1 |
Genome annotation databases
GeneIDi | 8452 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299644 mRNA Translation: BAH13086.1 |
RefSeqi | NP_001244126.1, NM_001257197.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B7Z600 |
Protocols and materials databases
DNASUi | 8452 |
Genome annotation databases
GeneIDi | 8452 |
Organism-specific databases
CTDi | 8452 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
BioGRID-ORCSi | 8452, 518 hits in 1155 CRISPR screens |
GenomeRNAii | 8452 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR045093, Cullin IPR016157, Cullin_CS IPR016158, Cullin_homology IPR036317, Cullin_homology_sf IPR001373, Cullin_N IPR019559, Cullin_neddylation_domain IPR016159, Cullin_repeat-like_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11932, PTHR11932, 1 hit |
Pfami | View protein in Pfam PF00888, Cullin, 1 hit PF10557, Cullin_Nedd8, 1 hit |
SMARTi | View protein in SMART SM00182, CULLIN, 1 hit SM00884, Cullin_Nedd8, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF74788, SSF74788, 1 hit SSF75632, SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS01256, CULLIN_1, 1 hit PS50069, CULLIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z600_HUMAN | |
Accessioni | B7Z600Primary (citable) accession number: B7Z600 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | May 25, 2022 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |