UniProtKB - B7Z4W4 (B7Z4W4_HUMAN)
Protein
UV excision repair protein RAD23
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.UniRule annotation
GO - Molecular functioni
- damaged DNA binding Source: UniProtKB-UniRule
- polyubiquitin modification-dependent protein binding Source: UniProtKB-UniRule
- ubiquitin binding Source: UniProtKB-UniRule
GO - Biological processi
- nucleotide-excision repair Source: UniProtKB-UniRule
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB-UniRule
Keywordsi
Biological process | DNA damage, DNA repairUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: UV excision repair protein RAD23UniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB-UniRule
Nucleus
- nucleoplasm Source: UniProtKB-UniRule
Other locations
- proteasome complex Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotation, ProteasomeARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | B7Z4W4 |
PRIDEi | B7Z4W4 |
Interactioni
GO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: UniProtKB-UniRule
- ubiquitin binding Source: UniProtKB-UniRule
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 58 | Ubiquitin-likeInterPro annotationAdd BLAST | 58 | |
Domaini | 167 – 207 | UBAInterPro annotationAdd BLAST | 41 | |
Domaini | 343 – 383 | UBAInterPro annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 59 – 154 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 215 – 256 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 60 – 90 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 98 – 118 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 136 – 154 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 219 – 256 | PolarSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotationFamily and domain databases
CDDi | cd14377, UBA1_Rad23, 1 hit |
Gene3Di | 1.10.10.540, 1 hit |
InterProi | View protein in InterPro IPR004806, Rad23 IPR041811, RAD23A/B_UBA1 IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR015360, XPC-bd IPR036353, XPC-bd_sf |
Pfami | View protein in Pfam PF00627, UBA, 2 hits PF00240, ubiquitin, 1 hit PF09280, XPC-binding, 1 hit |
PRINTSi | PR01839, RAD23PROTEIN |
SMARTi | View protein in SMART SM00727, STI1, 1 hit SM00165, UBA, 2 hits |
SUPFAMi | SSF101238, SSF101238, 1 hit SSF46934, SSF46934, 2 hits SSF54236, SSF54236, 1 hit |
TIGRFAMsi | TIGR00601, rad23, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 2 hits PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B7Z4W4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKALKEKIE SEKGKDAFPV AGQKLIYAGK ILNDDTALKE YKIDEKNFVV
60 70 80 90 100
VMVTKPKAVS TPAPATTQQS APASTTAVTS STTTTVAQAP TPVPALAPTS
110 120 130 140 150
TPASITPASA TASSEPAPAS AAKQEKPAEK PAETPVATSP TATDSTSGDS
160 170 180 190 200
SRSNLFEDAT SALVTGQSYE NMVTEIMSMG YEREQVIAAL RASFNNPDRA
210 220 230 240 250
VEYLLMGIPG DRESQAVVDP PQAASTGAPQ SSAVAAAAAT TTATTTTTSS
260 270 280 290 300
GGHPLEFLRN QPQFQQMRQI IQQNPSLLPA LLQQIGRENP QLLQQISQHQ
310 320 330 340 350
EHFIQMLNEP VQEAGGQGGG GGGGSGGIAE AGSGHMNYIQ VTPQEKEAIE
360 370 380
RLKALGFPEG LVIQAYFACE KNENLAANFL LQQNFDED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297986 mRNA Translation: BAH12700.1 |
RefSeqi | NP_001231642.1, NM_001244713.1 NP_001231653.1, NM_001244724.1 |
Genome annotation databases
GeneIDi | 5887 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297986 mRNA Translation: BAH12700.1 |
RefSeqi | NP_001231642.1, NM_001244713.1 NP_001231653.1, NM_001244724.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B7Z4W4 |
PRIDEi | B7Z4W4 |
Protocols and materials databases
DNASUi | 5887 |
Genome annotation databases
GeneIDi | 5887 |
Organism-specific databases
CTDi | 5887 |
Miscellaneous databases
BioGRID-ORCSi | 5887, 10 hits in 851 CRISPR screens |
GenomeRNAii | 5887 |
Gene expression databases
Genevisiblei | B7Z4W4, HS |
Family and domain databases
CDDi | cd14377, UBA1_Rad23, 1 hit |
Gene3Di | 1.10.10.540, 1 hit |
InterProi | View protein in InterPro IPR004806, Rad23 IPR041811, RAD23A/B_UBA1 IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR015360, XPC-bd IPR036353, XPC-bd_sf |
Pfami | View protein in Pfam PF00627, UBA, 2 hits PF00240, ubiquitin, 1 hit PF09280, XPC-binding, 1 hit |
PRINTSi | PR01839, RAD23PROTEIN |
SMARTi | View protein in SMART SM00727, STI1, 1 hit SM00165, UBA, 2 hits |
SUPFAMi | SSF101238, SSF101238, 1 hit SSF46934, SSF46934, 2 hits SSF54236, SSF54236, 1 hit |
TIGRFAMsi | TIGR00601, rad23, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 2 hits PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z4W4_HUMAN | |
Accessioni | B7Z4W4Primary (citable) accession number: B7Z4W4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |