UniProtKB - B7Z3P7 (B7Z3P7_HUMAN)
Protein
Histone deacetylase
Gene
HDAC9
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.5.1.98ARBA annotation
GO - Molecular functioni
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HDAC9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000048052.21 |
HGNCi | HGNC:14065, HDAC9 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- histone deacetylase complex Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000048052, Expressed in corpus callosum and 229 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 127 | HDAC4_GlnInterPro annotationAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 113 – 173 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 186 – 263 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 453 – 519 | DisorderedSequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 113 – 145 | PolyampholyteSequence analysisAdd BLAST | 33 | |
Compositional biasi | 149 – 172 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 186 – 205 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 221 – 263 | PolarSequence analysisAdd BLAST | 43 | |
Compositional biasi | 456 – 473 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 475 – 495 | PolarSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000160307 |
Family and domain databases
InterProi | View protein in InterPro IPR024643, Hist_deacetylase_Gln_rich_N IPR017320, Histone_deAcase_II_euk |
PANTHERi | PTHR45364, PTHR45364, 2 hits |
Pfami | View protein in Pfam PF12203, HDAC4_Gln, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
B7Z3P7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL
60 70 80 90 100
LLIQQQQQIQ KQLLIAEFQK QHENLTRQHQ AQLQEHIKLQ QELLAIKQQQ
110 120 130 140 150
ELLEKEQKLE QQRQEQEVER HRREQQLPPL RGKDRGRERA VASTEVKQKL
160 170 180 190 200
QEFLLSKSAT KDTPTNGKNH SVSRHPKLWY TAAHHTSLDQ SSPPLSGTSP
210 220 230 240 250
SYKYTLPGAQ DAKDDFPLRK TESSVSSSSP GSGPSSPNNG PTGSVTENET
260 270 280 290 300
SVLPPTPHAE QMVSQQRILI HEDSMNLLSL YTSPSLPNIT LGLPAVPSQL
310 320 330 340 350
NASNSLKEKQ KCETQTLRQG VPLPGQYGGS IPASSSHPHV TLEGKPPNSS
360 370 380 390 400
HQALLQHLLL KEQMRQQKLL VAGGVPLHPQ SPLATKERIS PGIRGTHKLP
410 420 430 440 450
RHRPLNRTQS APLPQSTLAQ LVIQQQHQQF LEKQKQYQQQ IHMNKLLSKS
460 470 480 490 500
IEQLKQPGSH LEEAEEELQG DQAMQEDRAP SSGNSTRSDS SACVDDTLGQ
510 520 530 540
VGAVKVKEEP VDSDEDAQIQ EMESGEQAAF MQQVIGKDLA PGFVIKVII
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UKV0 | HDAC9_HUMAN | Histone deacetylase 9 | HDAC9 HDAC7, HDAC7B, HDRP, KIAA0744, MITR | 1,011 | Annotation score: | ||
B5MCF1 | B5MCF1_HUMAN | Histone deacetylase | HDAC9 | 577 | Annotation score: | ||
C9J835 | C9J835_HUMAN | Histone deacetylase | HDAC9 | 70 | Annotation score: | ||
C9JD56 | C9JD56_HUMAN | Histone deacetylase | HDAC9 | 110 | Annotation score: | ||
C9J1W4 | C9J1W4_HUMAN | Histone deacetylase | HDAC9 | 148 | Annotation score: | ||
C9IZS0 | C9IZS0_HUMAN | Histone deacetylase | HDAC9 | 138 | Annotation score: | ||
C9JLX1 | C9JLX1_HUMAN | Histone deacetylase 9 | HDAC9 | 22 | Annotation score: | ||
F8WDS2 | F8WDS2_HUMAN | Histone deacetylase 9 | HDAC9 | 38 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002124 Genomic DNA No translation available. AC002433 Genomic DNA No translation available. AC005249 Genomic DNA No translation available. AC010082 Genomic DNA No translation available. AC074193 Genomic DNA No translation available. AC091697 Genomic DNA No translation available. KF458392 Genomic DNA No translation available. KF458393 Genomic DNA No translation available. AK296214 mRNA Translation: BAH12283.1 AK316109 mRNA Translation: BAH14480.1 |
RefSeqi | NP_001191075.1, NM_001204146.2 NP_001308798.1, NM_001321869.1 NP_001308799.1, NM_001321870.1 NP_001308801.1, NM_001321872.1 NP_001308802.1, NM_001321873.1 NP_001308823.1, NM_001321894.1 NP_001308824.1, NM_001321895.1 |
Genome annotation databases
Ensembli | ENST00000622668; ENSP00000478829; ENSG00000048052 |
GeneIDi | 9734 |
UCSCi | uc011jyc.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002124 Genomic DNA No translation available. AC002433 Genomic DNA No translation available. AC005249 Genomic DNA No translation available. AC010082 Genomic DNA No translation available. AC074193 Genomic DNA No translation available. AC091697 Genomic DNA No translation available. KF458392 Genomic DNA No translation available. KF458393 Genomic DNA No translation available. AK296214 mRNA Translation: BAH12283.1 AK316109 mRNA Translation: BAH14480.1 |
RefSeqi | NP_001191075.1, NM_001204146.2 NP_001308798.1, NM_001321869.1 NP_001308799.1, NM_001321870.1 NP_001308801.1, NM_001321872.1 NP_001308802.1, NM_001321873.1 NP_001308823.1, NM_001321894.1 NP_001308824.1, NM_001321895.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 6494, 594 antibodies |
DNASUi | 9734 |
Genome annotation databases
Ensembli | ENST00000622668; ENSP00000478829; ENSG00000048052 |
GeneIDi | 9734 |
UCSCi | uc011jyc.3, human |
Organism-specific databases
CTDi | 9734 |
EuPathDBi | HostDB:ENSG00000048052.21 |
HGNCi | HGNC:14065, HDAC9 |
OpenTargetsi | ENSG00000048052 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160307 |
Miscellaneous databases
BioGRID-ORCSi | 9734, 8 hits in 856 CRISPR screens |
ChiTaRSi | HDAC9, human |
GenomeRNAii | 9734 |
Gene expression databases
Bgeei | ENSG00000048052, Expressed in corpus callosum and 229 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR024643, Hist_deacetylase_Gln_rich_N IPR017320, Histone_deAcase_II_euk |
PANTHERi | PTHR45364, PTHR45364, 2 hits |
Pfami | View protein in Pfam PF12203, HDAC4_Gln, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z3P7_HUMAN | |
Accessioni | B7Z3P7Primary (citable) accession number: B7Z3P7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |