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Protein

Delta-aminolevulinic acid dehydratase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi105Zinc 1; catalyticUniRule annotation1
Metal bindingi107Zinc 1; catalyticUniRule annotation1
Metal bindingi114Zinc 2UniRule annotation1
Metal bindingi115Zinc 1; catalyticUniRule annotation1
Active sitei182Schiff-base intermediate with substrateUniRule annotation1
Binding sitei192Substrate 1UniRule annotation1
Binding sitei204Substrate 1UniRule annotation1
Metal bindingi206Zinc 2UniRule annotation1
Active sitei235Schiff-base intermediate with substrateUniRule annotation1
Binding sitei262Substrate 2UniRule annotation1
Binding sitei301Substrate 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processPorphyrin biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

MaxQBiB7Z3I9
PeptideAtlasiB7Z3I9
PRIDEiB7Z3I9

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7Z3I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001222

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR001731 ALAD
IPR030656 ALAD_AS
IPR013785 Aldolase_TIM
PANTHERiPTHR11458 PTHR11458, 1 hit
PfamiView protein in Pfam
PF00490 ALAD, 1 hit
PIRSFiPIRSF001415 Porphbilin_synth, 1 hit
PRINTSiPR00144 DALDHYDRTASE
SMARTiView protein in SMART
SM01004 ALAD, 1 hit
PROSITEiView protein in PROSITE
PS00169 D_ALA_DEHYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z3I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTYG VKRLEEMLRP
60 70 80 90 100
LVEEGLRCVL IFGVPSRVPK DERGSAADSE ESPAIEAIHL LRKTFPNLLV
110 120 130 140 150
ACDVCLCPYT SHGHCGLLSE NGAFRAEESR QRLAEVALAY AKAGCQVVAP
160 170 180 190 200
SDMMDGRVEA IKEALMAHGL GNRVSVMSYS AKFASCFYGP FRDAAKSSPA
210 220 230 240 250
FGDRRCYQLP PGARGLALRA VDRDVREGAD MLMVKPGMPY LDIVREVKDK
260 270 280 290 300
HPDLPLAVYH VSGEFAMLWH GAQAGAFDLK AAVLEAMTAF RRAGADIIIT
310
YYTPQLLQWL KEE
Length:313
Mass (Da):34,520
Last modified:March 3, 2009 - v1
Checksum:iEA8A783C37E9C899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295945 mRNA Translation: BAH12225.1
RefSeqiNP_001304674.1, NM_001317745.1
UniGeneiHs.1227

Genome annotation databases

GeneIDi210

Similar proteinsi

Entry informationi

Entry nameiB7Z3I9_HUMAN
AccessioniPrimary (citable) accession number: B7Z3I9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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