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Protein
Submitted name:

cDNA FLJ50545, highly similar to Tyrosine-protein phosphatase non-receptor type3

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei688Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ50545, highly similar to Tyrosine-protein phosphatase non-receptor type3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z3H5
PRIDEiB7Z3H5

Structurei

3D structure databases

ProteinModelPortaliB7Z3H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 203FERMInterPro annotationAdd BLAST203
Domaini356 – 428PDZInterPro annotationAdd BLAST73
Domaini492 – 747Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini665 – 738TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Phylogenomic databases

HOVERGENiHBG008322

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z3H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSKQTHQE AVKRHLYFLQ LKMDICEGRL TCPLNSAVVL ASYAVQSHFG
60 70 80 90 100
DYNSSIHHPG YLSDSHFIPD QNEDFLTKVE SLHEQHSGLK QSEAESCYIN
110 120 130 140 150
IARTLDFYGV ELHSGRDLHN LDLMIGIASA GVAVYRKYIC TSFYPWVNIL
160 170 180 190 200
KISFKRKKFF IHQRQKQAES REHIVAFNML NYRSCKNLWK SCVEHHTFFQ
210 220 230 240 250
AKKLLPQEKN VLSQYWTMGS RNTKKRSPRL RHEIRKPRHS SADNLANEMT
260 270 280 290 300
YITETEDVFY TYKGSLAPQD SDSEVSQNRS PHQESLSENN PAQSYLTQKS
310 320 330 340 350
SSSVSPSSNA PGSCSPDGVD QQLLDDFHRV TKGGSTEDAS QYYCDKNDNG
360 370 380 390 400
DSYLVLIRIT PDEDGKFGFN LKGGVDQKMP LVVSRINPES PADTCIPKLN
410 420 430 440 450
EGDQIVLING RDISEHTHDQ VVMFIKASRE SHSRELALVI RRRAVRSFAD
460 470 480 490 500
FKSEDELNQL FPEAIFPMCP EGGDTLEGSM AQLKKGLESG TVLIQFEQLY
510 520 530 540 550
RKKPGLAITF AKLPQNLDKN RYKDVLPYDT TRVLLQGNED YINASYVNME
560 570 580 590 600
IPAANLVNKY IATQGPLPHT CAQFWQVVWD QKLSLIVMLT TLTERGRTKC
610 620 630 640 650
HQYWPDPPDV MNHGGFHIQC QSEDCTIAYV SREMLVTNTQ TGEEHTVTHL
660 670 680 690 700
QYVAWPDHGV PDDSSDFLEF VNYVRSLRVD SEPVLVHCSA GIGRTGVLVT
710 720 730 740 750
METAMCLTER NLPIYPLDIV RKMRDQRAMM VQTSSQYKFV CEAILRVYEE

GLVQMLDPS
Length:759
Mass (Da):86,319
Last modified:March 3, 2009 - v1
Checksum:i6C701A68746B602B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295875 mRNA Translation: BAH12211.1
UniGeneiHs.436429

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295875 mRNA Translation: BAH12211.1
UniGeneiHs.436429

3D structure databases

ProteinModelPortaliB7Z3H5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB7Z3H5
PRIDEiB7Z3H5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008322

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z3H5_HUMAN
AccessioniPrimary (citable) accession number: B7Z3H5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 12, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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