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Protein
Submitted name:

cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z313
PRIDEiB7Z313

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 56APP_E2InterPro annotationAdd BLAST56
Domaini183 – 221Beta-APPInterPro annotationAdd BLAST39
Domaini224 – 274APP_amyloidInterPro annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 83Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3540 Eukaryota
ENOG410ZW2A LUCA
HOGENOMiHOG000232190
HOVERGENiHBG000051

Family and domain databases

Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
4.10.230.10, 1 hit
InterProiView protein in InterPro
IPR008155 Amyloid_glyco
IPR013803 Amyloid_glyco_Abeta
IPR037071 Amyloid_glyco_Abeta_sf
IPR024329 Amyloid_glyco_E2_domain
IPR019745 Amyloid_glyco_intracell_CS
IPR028866 APP
IPR019543 APP_amyloid_C
IPR036176 E2_sf
IPR011993 PH-like_dom_sf
PANTHERiPTHR23103 PTHR23103, 1 hit
PTHR23103:SF7 PTHR23103:SF7, 1 hit
PfamiView protein in Pfam
PF10515 APP_amyloid, 1 hit
PF12925 APP_E2, 1 hit
PF03494 Beta-APP, 1 hit
PRINTSiPR00203 AMYLOIDA4
PR00204 BETAAMYLOID
SUPFAMiSSF109843 SSF109843, 1 hit
PROSITEiView protein in PROSITE
PS00320 A4_INTRA, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRSQVMT HLRVIYERMN
60 70 80 90 100
QSLSLLYNVP AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA
110 120 130 140 150
LMPSLTETKT TVELLPVNGE FSLDDLQPWH SFGADSVPAN TENEVEPVDA
160 170 180 190 200
RPAADRGLTT RPGSGLTNIK TEEISEVKMD AEFRHDSGYE VHHQKLVFFA
210 220 230 240 250
EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV
260 270
TPEERHLSKM QQNGYENPTY KFFEQMQN
Length:278
Mass (Da):31,450
Last modified:March 3, 2009 - v1
Checksum:i0E42419A05F5387E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295373 mRNA Translation: BAH12049.1
UniGeneiHs.434980

Similar proteinsi

Entry informationi

Entry nameiB7Z313_HUMAN
AccessioniPrimary (citable) accession number: B7Z313
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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