UniProtKB - B7Z313 (B7Z313_HUMAN)
Protein
ABPP
Gene
N/A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: ABPPARBA annotationAlternative name(s): Amyloid precursor proteinARBA annotation Amyloid-beta A4 proteinARBA annotation Amyloid-beta precursor proteinARBA annotation Amyloid-beta protein 40ARBA annotation Amyloid-beta protein 42ARBA annotation Beta-APP40ARBA annotation Beta-APP42ARBA annotation Gamma-CTF(57)ARBA annotation Gamma-CTF(59)ARBA annotation Gamma-secretase C-terminal fragment 57ARBA annotation Gamma-secretase C-terminal fragment 59ARBA annotation Soluble APP-betaARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Endosome
- Early endosome ARBA annotation
- Endosome ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- growth cone ARBA annotation
- Cell surface ARBA annotation
- Cytoplasmic vesicle ARBA annotation
- clathrin-coated pit ARBA annotation
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
- Perikaryon ARBA annotation
- Vesicle ARBA annotation
Endosome
- early endosome Source: UniProtKB-SubCell
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- cell surface Source: UniProtKB-SubCell
- growth cone Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 209 – 231 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Coated pitARBA annotation, Cytoplasmic vesicleARBA annotation, EndosomeARBA annotation, MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 73 | E2InterPro annotationAdd BLAST | 73 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 63 – 83 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 4.10.230.10, 1 hit |
InterProi | View protein in InterPro IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR024329, Amyloid_glyco_E2_domain IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR036176, E2_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12925, APP_E2, 1 hit PF03494, Beta-APP, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00204, BETAAMYLOID |
SUPFAMi | SSF109843, SSF109843, 1 hit |
PROSITEi | View protein in PROSITE PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit |
i Sequence
Sequence statusi: Complete.
B7Z313-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRSQVMT HLRVIYERMN
60 70 80 90 100
QSLSLLYNVP AVAEEIQDEV DELLQKEQNY SDDVLANMIS EPRISYGNDA
110 120 130 140 150
LMPSLTETKT TVELLPVNGE FSLDDLQPWH SFGADSVPAN TENEVEPVDA
160 170 180 190 200
RPAADRGLTT RPGSGLTNIK TEEISEVKMD AEFRHDSGYE VHHQKLVFFA
210 220 230 240 250
EDVGSNKGAI IGLMVGGVVI ATVIVITLVM LKKKQYTSIH HGVVEVDAAV
260 270
TPEERHLSKM QQNGYENPTY KFFEQMQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295373 mRNA Translation: BAH12049.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295373 mRNA Translation: BAH12049.1 |
3D structure databases
SMRi | B7Z313 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B7Z313 |
Family and domain databases
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 4.10.230.10, 1 hit |
InterProi | View protein in InterPro IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR024329, Amyloid_glyco_E2_domain IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR036176, E2_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12925, APP_E2, 1 hit PF03494, Beta-APP, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00204, BETAAMYLOID |
SUPFAMi | SSF109843, SSF109843, 1 hit |
PROSITEi | View protein in PROSITE PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z313_HUMAN | |
Accessioni | B7Z313Primary (citable) accession number: B7Z313 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |