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Entry version 47 (31 Jul 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

cDNA FLJ56626, highly similar to Mus musculus regulating synaptic membrane exocytosis 1 (Rims1), transcript variant 5, mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ56626, highly similar to Mus musculus regulating synaptic membrane exocytosis 1 (Rims1), transcript variant 5, mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7Z2W4

PRoteomics IDEntifications database

More...
PRIDEi
B7Z2W4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 208PDZInterPro annotationAdd BLAST87
Domaini272 – 367C2InterPro annotationAdd BLAST96
Domaini840 – 928C2InterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 72DisorderedSequence analysisAdd BLAST72
Regioni215 – 249DisorderedSequence analysisAdd BLAST35
Regioni387 – 566DisorderedSequence analysisAdd BLAST180
Regioni620 – 682DisorderedSequence analysisAdd BLAST63
Regioni696 – 716DisorderedSequence analysisAdd BLAST21
Regioni733 – 783DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 29PolarSequence analysisAdd BLAST15
Compositional biasi221 – 247PolarSequence analysisAdd BLAST27
Compositional biasi406 – 427PolyampholyteSequence analysisAdd BLAST22
Compositional biasi445 – 460PolarSequence analysisAdd BLAST16
Compositional biasi461 – 480PolyampholyteSequence analysisAdd BLAST20
Compositional biasi509 – 538PolyampholyteSequence analysisAdd BLAST30
Compositional biasi539 – 566PolarSequence analysisAdd BLAST28
Compositional biasi621 – 663PolarSequence analysisAdd BLAST43
Compositional biasi733 – 748PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060 Eukaryota
ENOG41111ZT LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR039032 Rim-like
IPR030630 RIM1

The PANTHER Classification System

More...
PANTHERi
PTHR12157 PTHR12157, 2 hits
PTHR12157:SF19 PTHR12157:SF19, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7Z2W4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKAKREKVE TMLRNDSLSS DQSESVRPSP PKPHRSKRGG KKRQMSVSSS
60 70 80 90 100
EEEGVSTPEY TSCEDVELES ESVSEKGDLD YYWLDPATWH SRETSPISSH
110 120 130 140 150
PVTWQPSKEG DRLIGRVILN KRTTMPKDSG ALLGLKVVGG KMTDLGRLGA
160 170 180 190 200
FITKVKKGSL ADVVGHLRAG DEVLEWNGKP LPGATNEEVY NIILESKSEP
210 220 230 240 250
QVEIIVSRPI GDIPRIPESS HPPLESSSSS FESQKMERPS ISVISPTSPG
260 270 280 290 300
ALKDAPQVLP GQLSVKLWYD KVGHQLIVNV LQATDLPARV DGRPRNPYVK
310 320 330 340 350
MYFLPDRSDK NKRRTKTVKK ILEPKWNQTF VYSHVHRRDF RERMLEITVW
360 370 380 390 400
DQPRVQEEES EFLGEILIEL ETALLDDEPH WYKLQTHDES SLPLPQPSPF
410 420 430 440 450
MPRRHIHGES SSKKLQRSQR ISDSDISDYE VDDGIGVVPP GYRSSARESK
460 470 480 490 500
STTLTVPEQQ RTTHHRSRSV SPHRGNDQGK PRSRLPNVPL QRSLDEIHPT
510 520 530 540 550
RRSRSPTRHH DASRSPVDHR TRDVDSQYLS EQDRMHRQRS PTQSPPADTS
560 570 580 590 600
FSSRRGRQLP QVPVRSGSIE QASLVVEERT RQMKMKVHRF KQTTGSGSSQ
610 620 630 640 650
ELDREQYSKY NIHKDQYRSC DNVSAKSSDS DVSDVSAISR TSSASRLSST
660 670 680 690 700
SFMSEQSERP RGRISSFTPK MQGRRMGTSG RSIMKSTSVS GEMYTLEHND
710 720 730 740 750
GSQSDTAVGT VGAGGKKRRS SLSAKVVAIV SRRSRSTSQL SQTESGHKKL
760 770 780 790 800
KSTIQRSTET GMAAEMRKMV RQPSRESTDG SINSYSSEGN LIFPGVRLGA
810 820 830 840 850
DSQFSDFLDG LGPAQLVGRQ TLATPAMGDI QIGMEDKKGQ LEVEVIRARS
860 870 880 890 900
LTQKPGSKST PAPYVKVYLL ENGACIAKKK TRIARKTLDP LYQQSLVFDE
910 920 930 940 950
SPQGKVLQVI VWGDYGRMDH KCFMGVAQIL LEELDLSSMV IGWYKLFPPS
960 970 980
SLVDPTLTPL TRRASQSSLE SSTGPPCIRS
Length:980
Mass (Da):109,540
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC41D63FB6CA8FD1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK295177 mRNA Translation: BAH12000.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295177 mRNA Translation: BAH12000.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB7Z2W4
PRIDEiB7Z2W4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
ENOG41111ZT LUCA

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR039032 Rim-like
IPR030630 RIM1
PANTHERiPTHR12157 PTHR12157, 2 hits
PTHR12157:SF19 PTHR12157:SF19, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7Z2W4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7Z2W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 31, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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