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UniProtKB - B7Z2V2 (B7Z2V2_HUMAN)
Protein
Alkaline ceramidase
Gene
ACER3
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- This reaction proceeds in the forwardARBA annotation direction.
- EC:3.5.1.23ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
: sphingolipid metabolism Pathwayi
This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.
Pathwayi: Sphingolipid metabolism
This protein is involved in Sphingolipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in Sphingolipid metabolism.
GO - Molecular functioni
- ceramidase activity Source: UniProtKB-EC
- N-acylsphingosine amidohydrolase activity Source: UniProtKB-EC
GO - Biological processi
- ceramide metabolic process Source: InterPro
- sphingosine biosynthetic process Source: UniProt
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Biological process | Lipid metabolism, Sphingolipid metabolismARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00222 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACER3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16066, ACER3 |
VEuPathDBi | HostDB:ENSG00000078124 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 54 – 73 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 79 – 100 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 121 – 142 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000078124, Expressed in placenta and 220 other tissues |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00730000110920 |
Family and domain databases
InterProi | View protein in InterPro IPR008901, ACER |
PANTHERi | PTHR46187, PTHR46187, 1 hit |
Pfami | View protein in Pfam PF05875, Ceramidase, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All
B7Z2V2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIYSCCIFVY CMFECFKIKN SVNYHLLFTL VLFSLIVTTV YLKVKEPIFH
60 70 80 90 100
QVMYGMLVFT LVLRSIYIVT WVYPWLRGLG YTSLGIFLLG FLFWNIDNIF
110 120 130 140 150
CESLRNFRKK VPPIIGITTQ FHAWWHILTG LGSYLHILFS LYTRTLYLRY
160 170
RPKVKFLFGI WPVILFEPLR KH
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NUN7 | ACER3_HUMAN | Alkaline ceramidase 3 | ACER3 APHC, PHCA | 267 | Annotation score: | ||
B7Z2Q2 | B7Z2Q2_HUMAN | Alkaline ceramidase | ACER3 | 230 | Annotation score: | ||
E9PIN9 | E9PIN9_HUMAN | Alkaline ceramidase | ACER3 | 205 | Annotation score: | ||
E9PLZ9 | E9PLZ9_HUMAN | Alkaline ceramidase | ACER3 | 150 | Annotation score: | ||
A0A7P0T8K3 | A0A7P0T8K3_HUMAN | Alkaline ceramidase | ACER3 | 165 | Annotation score: | ||
A0A7P0T836 | A0A7P0T836_HUMAN | Alkaline ceramidase | ACER3 | 200 | Annotation score: | ||
A0A7P0T842 | A0A7P0T842_HUMAN | Alkaline ceramidase | ACER3 | 71 | Annotation score: | ||
A0A7P0T912 | A0A7P0T912_HUMAN | Alkaline ceramidase | ACER3 | 274 | Annotation score: | ||
A0A7P0TAD8 | A0A7P0TAD8_HUMAN | Alkaline ceramidase | ACER3 | 179 | Annotation score: | ||
A0A7P0TAT0 | A0A7P0TAT0_HUMAN | Alkaline ceramidase | ACER3 | 112 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000752 Genomic DNA No translation available. AP002498 Genomic DNA No translation available. AP003119 Genomic DNA No translation available. KC877444 Genomic DNA No translation available. KF455419 Genomic DNA No translation available. AK295142 mRNA Translation: BAH11988.1 AK316120 mRNA Translation: BAH14491.1 |
RefSeqi | NP_001287883.1, NM_001300954.1 NP_001287884.1, NM_001300955.1 |
Genome annotation databases
Ensembli | ENST00000526597; ENSP00000431149; ENSG00000078124 ENST00000680583; ENSP00000505842; ENSG00000078124 |
GeneIDi | 55331 |
UCSCi | uc010rsj.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000752 Genomic DNA No translation available. AP002498 Genomic DNA No translation available. AP003119 Genomic DNA No translation available. KC877444 Genomic DNA No translation available. KF455419 Genomic DNA No translation available. AK295142 mRNA Translation: BAH11988.1 AK316120 mRNA Translation: BAH14491.1 |
RefSeqi | NP_001287883.1, NM_001300954.1 NP_001287884.1, NM_001300955.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 6468 |
Protocols and materials databases
Antibodypediai | 53464, 126 antibodies from 25 providers |
DNASUi | 55331 |
Genome annotation databases
Ensembli | ENST00000526597; ENSP00000431149; ENSG00000078124 ENST00000680583; ENSP00000505842; ENSG00000078124 |
GeneIDi | 55331 |
UCSCi | uc010rsj.2, human |
Organism-specific databases
CTDi | 55331 |
HGNCi | HGNC:16066, ACER3 |
OpenTargetsi | ENSG00000078124 |
VEuPathDBi | HostDB:ENSG00000078124 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00730000110920 |
Enzyme and pathway databases
UniPathwayi | UPA00222 |
Miscellaneous databases
BioGRID-ORCSi | 55331, 7 hits in 1046 CRISPR screens |
ChiTaRSi | ACER3, human |
GenomeRNAii | 55331 |
Gene expression databases
Bgeei | ENSG00000078124, Expressed in placenta and 220 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR008901, ACER |
PANTHERi | PTHR46187, PTHR46187, 1 hit |
Pfami | View protein in Pfam PF05875, Ceramidase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z2V2_HUMAN | |
Accessioni | B7Z2V2Primary (citable) accession number: B7Z2V2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | January 19, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |