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Protein

Heparan-sulfate 6-O-sulfotransferase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferaseUniRule annotation (EC:2.8.2.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Keywords - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500286614620 – 486Heparan-sulfate 6-O-sulfotransferaseSequence analysisAdd BLAST467

Proteomic databases

PeptideAtlasiB7Z2U5
PRIDEiB7Z2U5

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Signal-anchorUniRule annotation, Transmembrane

Phylogenomic databases

eggNOGiKOG3955 Eukaryota
ENOG410XSW4 LUCA
HOGENOMiHOG000007772
HOVERGENiHBG083012

Family and domain databases

InterProiView protein in InterPro
IPR010635 Heparan_SO4-6-sulfoTrfase
IPR027417 P-loop_NTPase
IPR005331 Sulfotransferase
PANTHERiPTHR12812 PTHR12812, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z2U5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFLFAVIVL QYVCPGTECQ LLRLQAFSSP VPDPYRSEDE SSARFVPRYN
60 70 80 90 100
FTRGDLLRKV DFDIKGDDLI VFLHIQKTGG TTFGRHLVRN IQLEQPCECR
110 120 130 140 150
VGQKKCTCHR PGKRETWLFS RFSTGWSCGL HADWTELTSC VPSVVDGKRD
160 170 180 190 200
ARLRPSRWRI FQILDAASKD KRGSPNTNAG ANSPSSTKTR NTSKSGKNFH
210 220 230 240 250
YITILRDPVS RYLSEWRHVQ RGATWKASLH VCDGRPPTSE ELPSCYTGDD
260 270 280 290 300
WSGCPLKEFM DCPYNLANNR QVRMLSDLTL VGCYNLSVMP EKQRNKVLLE
310 320 330 340 350
SAKSNLKHMA FFGLTEFQRK TQYLFEKTFN MNFISPFTQY NTTRASSVEI
360 370 380 390 400
NEEIQKRIEG LNFLDMELYS YAKDLFLQRY QFMRQKEHQE ARRKRQEQRK
410 420 430 440 450
FLKGRLLQTH FQSQGQGQSQ NPNQNQSQNP NPNANQNLTQ NLMQNLTQSL
460 470 480
SQKENRESPK QNSGKEQNDN TSNGTNDYIG SVEKWR
Length:486
Mass (Da):56,241
Last modified:March 3, 2009 - v1
Checksum:iF790D30CF96779D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295118 mRNA Translation: BAH11981.1
UniGeneiHs.385956

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295118 mRNA Translation: BAH11981.1
UniGeneiHs.385956

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB7Z2U5
PRIDEiB7Z2U5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3955 Eukaryota
ENOG410XSW4 LUCA
HOGENOMiHOG000007772
HOVERGENiHBG083012

Family and domain databases

InterProiView protein in InterPro
IPR010635 Heparan_SO4-6-sulfoTrfase
IPR027417 P-loop_NTPase
IPR005331 Sulfotransferase
PANTHERiPTHR12812 PTHR12812, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z2U5_HUMAN
AccessioniPrimary (citable) accession number: B7Z2U5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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