UniProtKB - B7Z2T4 (B7Z2T4_HUMAN)
Protein
Submitted name:
Disks large homolog 2
Gene
DLG2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Disks large homolog 2ImportedSubmitted name: cDNA FLJ60066, highly similar to Discs large homolog 2Imported |
Gene namesi | Name:DLG2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2901, DLG2 |
VEuPathDBi | HostDB:ENSG00000150672.16 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150672, Expressed in corpus callosum and 170 other tissues |
ExpressionAtlasi | B7Z2T4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 98 – 185 | PDZInterPro annotationAdd BLAST | 88 | |
Domaini | 193 – 280 | PDZInterPro annotationAdd BLAST | 88 | |
Domaini | 421 – 502 | PDZInterPro annotationAdd BLAST | 82 | |
Domaini | 536 – 606 | SH3InterPro annotationAdd BLAST | 71 | |
Domaini | 662 – 837 | Guanylate kinase-likeInterPro annotationAdd BLAST | 176 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 791 – 811 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155156 |
OrthoDBi | 807583at2759 |
Family and domain databases
CDDi | cd12032, SH3_DLG2, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR016313, DLG1-like IPR019590, DLG1_PEST_dom IPR035759, DLG2_SH3 IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF10608, MAGUK_N_PEST, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF001741, MAGUK_DLGH, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM01277, MAGUK_N_PEST, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
B7Z2T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFFACYCALR TNVKKYRYQD EDAPHDHSLP RLTHEVRGPE LVHVSEKNLS
60 70 80 90 100
QIENVHGYVL QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT
110 120 130 140 150
LERGNSGLGF SIAGGTDNPH IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI
160 170 180 190 200
LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY VRRRRPILET VVEIKLFKGP
210 220 230 240 250
KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ VGDRLLMVNN
260 270 280 290 300
YSLEEVTHEE AVAILKNTSE VVYLKVGKPT TIYMTDPYGP PDITHSYSPP
310 320 330 340 350
MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLVDDDY TRPPEPVYST
360 370 380 390 400
VNKLCDKPAS PRHYSPVECD KSFLLSAPYS HYHLGLLPDS EMTSHSQHST
410 420 430 440 450
ATRQPSMTLQ RAVSLEGEPR KVVLHKGSTG LGFNIVGGED GEGIFVSFIL
460 470 480 490 500
AGGPADLSGE LQRGDQILSV NGIDLRGASH EQAAAALKGA GQTVTIIAQY
510 520 530 540 550
QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY VRAMFDYDKS
560 570 580 590 600
KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVMLEGDS EEMGVIPSKR
610 620 630 640 650
RVERKERARL KTVKFNAKPG VIDSKGDIPG LGDDGYGTKT LRGQEDLILS
660 670 680 690 700
YEPVTRQEIN YTRPVIILGP MKDRINDDLI SEFPDKFGSC VPHTTRPKRD
710 720 730 740 750
YEVDGRDYHF VISREQMEKD IQEHKFIEAG QYNDNLYGTS VQSVRFVAER
760 770 780 790 800
GKHCILDVSG NAIKRLQVAQ LYPIAIFIKP RSLEPLMEMN KRLTEEQAKK
810 820 830 840 850
TYDRAIKLEQ EFGEYFTAIV QGDTLEDIYN QCKLVIEEQS GPFIWIPSKE
KL
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ15700 | DLG2_HUMAN | Disks large homolog 2 | DLG2 | 870 | Annotation score: | ||
A0A3B3ITF1 | A0A3B3ITF1_HUMAN | Disks large homolog 2 | DLG2 | 1,012 | Annotation score: | ||
Q6ZSU2 | Q6ZSU2_HUMAN | Disks large homolog 2 | DLG2 | 552 | Annotation score: | ||
E9PIW2 | E9PIW2_HUMAN | Disks large homolog 2 | DLG2 | 811 | Annotation score: | ||
E9PN83 | E9PN83_HUMAN | Disks large homolog 2 | DLG2 | 866 | Annotation score: | ||
B5MCC5 | B5MCC5_HUMAN | Disks large homolog 2 | DLG2 | 348 | Annotation score: | ||
A0A3B3ISW2 | A0A3B3ISW2_HUMAN | Disks large homolog 2 | DLG2 | 890 | Annotation score: | ||
F8VYC1 | F8VYC1_HUMAN | Disks large homolog 2 | DLG2 | 797 | Annotation score: | ||
A8MUT9 | A8MUT9_HUMAN | Disks large homolog 2 | DLG2 | 232 | Annotation score: | ||
C9JFF9 | C9JFF9_HUMAN | Disks large homolog 2 | DLG2 | 108 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000773 Genomic DNA No translation available. AP003026 Genomic DNA No translation available. KC877445 Genomic DNA No translation available. KC877447 Genomic DNA No translation available. KC877450 Genomic DNA No translation available. KF455429 Genomic DNA No translation available. AK295094 mRNA Translation: BAH11970.1 |
RefSeqi | NP_001287912.1, NM_001300983.1 |
Genome annotation databases
Ensembli | ENST00000532653; ENSP00000435849; ENSG00000150672 |
GeneIDi | 1740 |
UCSCi | uc010rta.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000773 Genomic DNA No translation available. AP003026 Genomic DNA No translation available. KC877445 Genomic DNA No translation available. KC877447 Genomic DNA No translation available. KC877450 Genomic DNA No translation available. KF455429 Genomic DNA No translation available. AK295094 mRNA Translation: BAH11970.1 |
RefSeqi | NP_001287912.1, NM_001300983.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B7Z2T4 |
ProteomicsDBi | 6461 |
Protocols and materials databases
Antibodypediai | 8247, 356 antibodies |
DNASUi | 1740 |
Genome annotation databases
Ensembli | ENST00000532653; ENSP00000435849; ENSG00000150672 |
GeneIDi | 1740 |
UCSCi | uc010rta.2, human |
Organism-specific databases
CTDi | 1740 |
HGNCi | HGNC:2901, DLG2 |
OpenTargetsi | ENSG00000150672 |
VEuPathDBi | HostDB:ENSG00000150672.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155156 |
OrthoDBi | 807583at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1740, 2 hits in 983 CRISPR screens |
ChiTaRSi | DLG2, human |
GenomeRNAii | 1740 |
Gene expression databases
Bgeei | ENSG00000150672, Expressed in corpus callosum and 170 other tissues |
ExpressionAtlasi | B7Z2T4, baseline and differential |
Family and domain databases
CDDi | cd12032, SH3_DLG2, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR016313, DLG1-like IPR019590, DLG1_PEST_dom IPR035759, DLG2_SH3 IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF10608, MAGUK_N_PEST, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF001741, MAGUK_DLGH, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM01277, MAGUK_N_PEST, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z2T4_HUMAN | |
Accessioni | B7Z2T4Primary (citable) accession number: B7Z2T4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | April 7, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |