UniProtKB - B7Z2N5 (B7Z2N5_HUMAN)
Protein
Submitted name:
cDNA FLJ51840, highly similar to Alpha-actinin-2
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
Keywordsi
Molecular function | Actin-bindingSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ51840, highly similar to Alpha-actinin-2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 51 | Calponin-homology (CH)InterPro annotationAdd BLAST | 51 | |
Domaini | 60 – 166 | Calponin-homology (CH)InterPro annotationAdd BLAST | 107 | |
Domaini | 662 – 697 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 698 – 733 | EF-handInterPro annotationAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 181 – 208 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 298 – 318 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 346 – 366 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 402 – 429 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 580 – 614 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatSAAS annotationPhylogenomic databases
eggNOGi | KOG0035 Eukaryota COG5069 LUCA |
Family and domain databases
CDDi | cd00014 CH, 1 hit cd00051 EFh, 1 hit |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589 Actinin_actin-bd_CS IPR001715 CH-domain IPR036872 CH_dom_sf IPR011992 EF-hand-dom_pair IPR014837 EF-hand_Ca_insen IPR002048 EF_hand_dom IPR018159 Spectrin/alpha-actinin IPR002017 Spectrin_repeat |
Pfami | View protein in Pfam PF00307 CH, 2 hits PF08726 EFhand_Ca_insen, 1 hit PF00435 Spectrin, 4 hits |
SMARTi | View protein in SMART SM00033 CH, 1 hit SM00054 EFh, 2 hits SM00150 SPEC, 3 hits |
SUPFAMi | SSF47473 SSF47473, 1 hit SSF47576 SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00020 ACTININ_2, 1 hit PS50021 CH, 2 hits PS50222 EF_HAND_2, 2 hits |
i Sequence
Sequence statusi: Complete.
B7Z2N5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFHKIANVN KALDYIASKG VKLVSIGAEE IVDGNVKMTL GMIWTIILRF
60 70 80 90 100
AIQDISVEET SAKEGLLLWC QRKTAPYRNV NIQNFHTSWK DGLGLCALIH
110 120 130 140 150
RHRPDLIDYS KLNKDDPIGN INLAMEIAEK HLDIPKMLDA EDLVYTARPD
160 170 180 190 200
ERAIMTYVSC YYHAFAGAQK AETAANRICK VLAANQENER LMEEYERLAS
210 220 230 240 250
ELLEWIRRTI PWLENRTPEK TMQAMQKKLE DFRDYRRKHK PPKVQEKCQL
260 270 280 290 300
EINFNTLQTK LRISNRPAFM PSEGKMVSDI AGAWQRLEQA EKGYEEWLLN
310 320 330 340 350
EIRRLERLEH LAEKFRQKAS THETWAYGKE QILLQKDYES ASLTEVRALL
360 370 380 390 400
RKHEAFESDL AAHQDRVEQI AAIAQELNVL DYHDAVNVND RCQKICDQWD
410 420 430 440 450
RLGTLTQKRR EALERMEKLL ETIDQLHLEF AKRAAPFNNW MEGAMEDLQD
460 470 480 490 500
MFIVHSIEEI QSLITAHEQF KATLPEADGE RQSIMAIQNE VEKVIQSYNI
510 520 530 540 550
RISSSNPYST VTMDELRTKW DKVKQLVPIR DQSLQEELAR QHANERLRRQ
560 570 580 590 600
FAAQANAIGP WIQNKMEEIA RSSIQITGAL EDQMNQLKQY EHNIINYKNN
610 620 630 640 650
IDKLEGDHQL IQEALVFDNK HTNYTMEHIR VGWELLLTTI ARTINEVETQ
660 670 680 690 700
ILTRDAKGIT QEQMNEFRAS FNHFDRRKNG LMDHEDFRAC LISMGYDLGE
710 720 730 740 750
AEFARIMTLV DPNGQGTVTF QSFIDFMTRE TADTDTAEQV IASFRILASD
760 770 780 790 800
KPYILAEELR RELPPDQAQY CIKRMPAYSG PGSVPGGLDY AAFSSALYGE
SDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294906 mRNA Translation: BAH11921.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294906 mRNA Translation: BAH11921.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B7Z2N5 |
PRIDEi | B7Z2N5 |
Phylogenomic databases
eggNOGi | KOG0035 Eukaryota COG5069 LUCA |
Family and domain databases
CDDi | cd00014 CH, 1 hit cd00051 EFh, 1 hit |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589 Actinin_actin-bd_CS IPR001715 CH-domain IPR036872 CH_dom_sf IPR011992 EF-hand-dom_pair IPR014837 EF-hand_Ca_insen IPR002048 EF_hand_dom IPR018159 Spectrin/alpha-actinin IPR002017 Spectrin_repeat |
Pfami | View protein in Pfam PF00307 CH, 2 hits PF08726 EFhand_Ca_insen, 1 hit PF00435 Spectrin, 4 hits |
SMARTi | View protein in SMART SM00033 CH, 1 hit SM00054 EFh, 2 hits SM00150 SPEC, 3 hits |
SUPFAMi | SSF47473 SSF47473, 1 hit SSF47576 SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00020 ACTININ_2, 1 hit PS50021 CH, 2 hits PS50222 EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z2N5_HUMAN | |
Accessioni | B7Z2N5Primary (citable) accession number: B7Z2N5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | October 16, 2019 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |