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Protein
Submitted name:

F-box/WD repeat-containing protein 7

Gene

FBXW7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
F-box/WD repeat-containing protein 7Imported
Submitted name:
cDNA FLJ55681, highly similar to F-box/WD repeat protein 7Imported
Gene namesi
Name:FBXW7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109670.13
HGNCiHGNC:16712 FBXW7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109670

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501408566323 – 531Sequence analysisAdd BLAST509

Proteomic databases

MaxQBiB7Z2C8
PeptideAtlasiB7Z2C8
PRIDEiB7Z2C8

Expressioni

Gene expression databases

BgeeiENSG00000109670
ExpressionAtlasiB7Z2C8 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 148F-boxInterPro annotationAdd BLAST47
Domaini200 – 483WD_REPEATS_REGIONInterPro annotationAdd BLAST284
Repeati215 – 240WDPROSITE-ProRule annotationAdd BLAST26
Repeati241 – 280WDPROSITE-ProRule annotationAdd BLAST40
Repeati281 – 320WDPROSITE-ProRule annotationAdd BLAST40
Repeati321 – 360WDPROSITE-ProRule annotationAdd BLAST40
Repeati361 – 400WDPROSITE-ProRule annotationAdd BLAST40
Repeati401 – 440WDPROSITE-ProRule annotationAdd BLAST40
Repeati444 – 483WDPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

SignalSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0274 Eukaryota
ENOG410XRWX LUCA
HOGENOMiHOG000236264
HOVERGENiHBG051596

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z2C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFKCISLL LIWLIPGQST TGLVPCSATP TTFGDLRAAN GQGQQRRRIT
60 70 80 90 100
SVQPPTGLQE WLKMFQSWSG PEKLLALDEL IDSCEPTQVK HMMQVIEPQF
110 120 130 140 150
QRDFISLLPK ELALYVLSFL EPKDLLQAAQ TCRYWRILAE DNLLWREKCK
160 170 180 190 200
EEGIDEPLHI KRRKVIKPGF IHSPWKSAYI RQHRIDTNWR RGELKSPKVL
210 220 230 240 250
KGHDDHVITC LQFCGNRIVS GSDDNTLKVW SAVTGKCLRT LVGHTGGVWS
260 270 280 290 300
SQMRDNIIIS GSTDRTLKVW NAETGECIHT LYGHTSTVRC MHLHEKRVVS
310 320 330 340 350
GSRDATLRVW DIETGQCLHV LMGHVAAVRC VQYDGRRVVS GAYDFMVKVW
360 370 380 390 400
DPETETCLHT LQGHTNRVYS LQFDGIHVVS GSLDTSIRVW DVETGNCIHT
410 420 430 440 450
LTGHQSLTSG MELKDNILVS GNADSTVKIW DIKTGQCLQT LQGPNKHQSA
460 470 480 490 500
VTCLQFNKNF VITSSDDGTV KLWDLKTGEF IRNLVTLESG GSGGVVWRIR
510 520 530
ASNTKLVCAV GSRNGTEETK LLVLDFDVDM K
Length:531
Mass (Da):59,724
Last modified:March 3, 2009 - v1
Checksum:i11346DF035AC0F4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023424 Genomic DNA No translation available.
AC080078 Genomic DNA No translation available.
AK294568 mRNA Translation: BAH11814.1
UniGeneiHs.561245
Hs.717081

Genome annotation databases

EnsembliENST00000393956; ENSP00000377528; ENSG00000109670
UCSCiuc011cih.3 human

Similar proteinsi

Entry informationi

Entry nameiB7Z2C8_HUMAN
AccessioniPrimary (citable) accession number: B7Z2C8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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