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UniProtKB - B7Z2B3 (B7Z2B3_HUMAN)

Entry version 67 (10 Feb 2021)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

cDNA FLJ59503, highly similar to Semaphorin-5B

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation
Biological processDifferentiationARBA annotation, NeurogenesisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ59503, highly similar to Semaphorin-5BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei940 – 963HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500286668127 – 1057Sequence analysisAdd BLAST1031

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 495SemaInterPro annotationAdd BLAST451

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
2.20.100.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002165, Plexin_repeat
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR027231, Semaphorin
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11036, PTHR11036, 4 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF00090, TSP_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SM00209, TSP1, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF82895, SSF82895, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51004, SEMA, 1 hit
PS50092, TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7Z2B3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLAGPLAVS LLLPSLTLLV SHLSSSQDVS SEPSSEQQLC ALSKHPTVAF 
        60         70         80         90        100
EDLQPWVSNF TYPGARDFSQ LALDPSGNQL IVGARNYLFR LSLANVSLLQ 
       110        120        130        140        150
ATEWASSEDT RRSCQSKGKT EEECQNYVRV LIVAGRKVFM CGTNAFSPMC 
       160        170        180        190        200
TSRQVGNLSR TIEKINGVAR CPYDPRHNST AVISSQGELY AATVIDFSGR 
       210        220        230        240        250
DPAIYRSLGS GPPLRTAQYN SKWLNEPNFV AAYDIGLFAY FFLRENAVEH 
       260        270        280        290        300
DCGRTVYSRV ARVCKNDVGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE 
       310        320        330        340        350
LQSAFHLPEQ DLIYGVFTTN VNSIAASAVC AFNLSAISQA FNGPFRYQEN 
       360        370        380        390        400
PRAAWLPIAN PIPNFQCGTL PETGPNENLT ERSLQDAQRL FLMSEAVQPV 
       410        420        430        440        450
TPEPCVTQDS VRFSHLVVDL VQAKDTLYHV LYIGTESGTI LKALSTASRS 
       460        470        480        490        500
LHGCYLEELH VLPPGRREPL RSLRILHSAR ALFVGLRDGV LRVPLERCAA 
       510        520        530        540        550
YRSQGACLGA RDPYCGWDGK QQRCSTLEDS SNMSLWTQNI TACPVRNVTR 
       560        570        580        590        600
DGGFGPWSPW QPCEHLDGDN SGSCLCRARS CDSPRPRCGG LDCLGPAIHI 
       610        620        630        640        650
ANCSRNGAWT PWSSWALCST SCGIGFQVRQ RSCSNPAPRH GGRICVGKSR 
       660        670        680        690        700
EERFCNENTP CPVPIFWASW GSWSKCSSNC GGGTQSRRRA CENGNSCLGC 
       710        720        730        740        750
GVEFKTCNPE GCPEVRRNTP WTPWLPVNVT QGGARQEQRF RFTCRAPLAD 
       760        770        780        790        800
PHGLQFGRRR TETRTCPADG SGSCDTDALV EVLLRSGSTS PHTVSGGWAA 
       810        820        830        840        850
WGPWSSCSRD CELGFRVRKR TCTNPEPRNG GLPCVGDAAE YQDCNPQACP 
       860        870        880        890        900
GEDICLGLHT EEALCATQAC PEGWSPWSEW SKCTDDGAQS RSRHCEELLP 
       910        920        930        940        950
GSSACAGNSS QSRPCPYSEI PVILPASSME EATDCAGFNL IHLVATGISC 
       960        970        980        990       1000
FLGSGLLTLA VYLSCQHCQR QSQESTLVHP ATPNHLHYKG GGTPKNEKYT 
      1010       1020       1030       1040       1050
PMEFKTLNKN NLIPDDRANF YPLQQTNVYT TTYYPSPLNK HSFRPEASPG 

QRCFPNS
Length:1,057
Mass (Da):116,094
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0E3008324A30B89
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK294528 mRNA Translation: BAH11799.1

NCBI Reference Sequences

More...RefSeqi		NP_001243277.1, NM_001256348.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54437

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294528 mRNA Translation: BAH11799.1
RefSeqiNP_001243277.1, NM_001256348.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi54437

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54437

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54437, 5 hits in 864 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54437

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.20.100.10, 5 hits
InterProiView protein in InterPro
IPR002165, Plexin_repeat
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR027231, Semaphorin
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036, PTHR11036, 4 hits
PfamiView protein in Pfam
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF00090, TSP_1, 4 hits
SMARTiView protein in SMART
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SM00209, TSP1, 4 hits
SUPFAMiSSF101912, SSF101912, 1 hit
SSF82895, SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit
PS50092, TSP1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7Z2B3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7Z2B3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 10, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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