UniProtKB - B7Z279 (B7Z279_HUMAN)
Protein
Submitted name:
Gamma-aminobutyric acid receptor subunit beta-2
Gene
GABRB2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- extracellular ligand-gated ion channel activity Source: InterPro
- GABA-A receptor activity Source: InterPro
Keywordsi
Molecular function | Chloride channelARBA annotation, Ion channel, ReceptorImported |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Submitted name: Gamma-aminobutyric acid receptor subunit beta-2ImportedSubmitted name: cDNA FLJ53759, highly similar to Gamma-aminobutyric-acid receptor subunit beta-2Imported |
Gene namesi | Name:GABRB2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4082, GABRB2 |
VEuPathDBi | HostDB:ENSG00000145864.12 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 82 – 106 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 147 – 170 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 295 – 312 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PRIDEi | B7Z279 |
ProteomicsDBi | 6418 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145864, Expressed in primary visual cortex and 155 other tissues |
ExpressionAtlasi | B7Z279, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 81 | Neur_chan_LBDInterPro annotationAdd BLAST | 80 | |
Domaini | 89 – 309 | Neur_chan_membInterPro annotationAdd BLAST | 221 |
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154245 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR002289, GABAAb_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01160, GABAARBETA PR00253, GABAARECEPTR |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
B7Z279-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT GVTKIELPQF
60 70 80 90 100
SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY MPSILITILS
110 120 130 140 150
WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP YVKAIDMYLM
160 170 180 190 200
GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN EKMRLDVNKM
210 220 230 240 250
DPHENILLST LEIKNEMATS EAVMGLGDPR STMLAYDASS IQYRKAGLPR
260 270 280 290 300
HSFGRNALER HVAQKKSRLR RRASQLKITI PDLTDVNAID RWSRIFFPVV
310
FSFFNIVYWL YYVN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP47870 | GBRB2_HUMAN | Gamma-aminobutyric acid receptor su... | GABRB2 | 512 | Annotation score: | ||
E7EV50 | E7EV50_HUMAN | Gamma-aminobutyric acid receptor su... | GABRB2 | 411 | Annotation score: | ||
A0A6Q8PFU0 | A0A6Q8PFU0_HUMAN | Gamma-aminobutyric acid receptor su... | GABRB2 | 390 | Annotation score: | ||
A0A6Q8PGT5 | A0A6Q8PGT5_HUMAN | Gamma-aminobutyric acid receptor su... | GABRB2 | 205 | Annotation score: | ||
A0A6Q8PGD9 | A0A6Q8PGD9_HUMAN | Gamma-aminobutyric acid receptor su... | GABRB2 | 109 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008712 Genomic DNA No translation available. AC022120 Genomic DNA No translation available. AC091882 Genomic DNA No translation available. AC091989 Genomic DNA No translation available. KF458046 Genomic DNA No translation available. KF510900 Genomic DNA No translation available. AK294437 mRNA Translation: BAH11765.1 |
Genome annotation databases
Ensembli | ENST00000517547; ENSP00000429750; ENSG00000145864 |
UCSCi | uc063jhe.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008712 Genomic DNA No translation available. AC022120 Genomic DNA No translation available. AC091882 Genomic DNA No translation available. AC091989 Genomic DNA No translation available. KF458046 Genomic DNA No translation available. KF510900 Genomic DNA No translation available. AK294437 mRNA Translation: BAH11765.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | B7Z279 |
ProteomicsDBi | 6418 |
Protocols and materials databases
Antibodypediai | 4534, 323 antibodies |
Genome annotation databases
Ensembli | ENST00000517547; ENSP00000429750; ENSG00000145864 |
UCSCi | uc063jhe.1, human |
Organism-specific databases
HGNCi | HGNC:4082, GABRB2 |
OpenTargetsi | ENSG00000145864 |
VEuPathDBi | HostDB:ENSG00000145864.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154245 |
Miscellaneous databases
ChiTaRSi | GABRB2, human |
Gene expression databases
Bgeei | ENSG00000145864, Expressed in primary visual cortex and 155 other tissues |
ExpressionAtlasi | B7Z279, baseline and differential |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR002289, GABAAb_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01160, GABAARBETA PR00253, GABAARECEPTR |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z279_HUMAN | |
Accessioni | B7Z279Primary (citable) accession number: B7Z279 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |