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Protein

C2 calcium-dependent domain-containing protein 4D

Gene

C2CD4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4D
Gene namesi
Name:C2CD4D
Synonyms:FAM148D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000225556.1
HGNCiHGNC:37210 C2CD4D
neXtProtiNX_B7Z1M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165750504

Polymorphism and mutation databases

BioMutaiC2CD4D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003949601 – 353C2 calcium-dependent domain-containing protein 4DAdd BLAST353

Proteomic databases

PaxDbiB7Z1M9
PRIDEiB7Z1M9
ProteomicsDBi6351

PTM databases

iPTMnetiB7Z1M9
PhosphoSitePlusiB7Z1M9

Expressioni

Gene expression databases

BgeeiENSG00000225556 Expressed in 66 organ(s), highest expression level in C1 segment of cervical spinal cord

Structurei

3D structure databases

ProteinModelPortaliB7Z1M9
SMRiB7Z1M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 326C2PROSITE-ProRule annotationAdd BLAST108

Phylogenomic databases

eggNOGiENOG410IJI1 Eukaryota
ENOG4111ADP LUCA
GeneTreeiENSGT00530000063888
HOGENOMiHOG000060308
HOVERGENiHBG056001
InParanoidiB7Z1M9
OMAiDRIPQFF
OrthoDBiEOG091G0FUN
PhylomeDBiB7Z1M9
TreeFamiTF330989

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z1M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLLEKAGYK VGAAEPAARW APSGLFSKRR APGPPTSACP NVLTPDRIPQ
60 70 80 90 100
FFIPPRLPDP GGAVPAARRH VAGRGLPATC SLPHLAGREG WAFLPESPHT
110 120 130 140 150
RRRESLFHGP PPAPAGGLPA AQSRLHVSAP DLRLCRAPDS DTASSPDSSP
160 170 180 190 200
FGSPRPGLGR RRVSRPHSLS PEKASSADTS PHSPRRAGPP TPPLFHLDFL
210 220 230 240 250
CCQLRPTRES VLRLGPRGGQ LRLSTEYQAG PGRLRLRLVS AEGLPRPRSR
260 270 280 290 300
PGSGGGGCCV VLRLRPRVRP REQQSRVVKC SANPIFNEDF FFDGLGPPDL
310 320 330 340 350
AARSLRAKVL DRGAGLRRDV LLGECETPLI ALLPPLGGGL GPGSSLAPTH

LSL
Length:353
Mass (Da):37,583
Last modified:June 15, 2010 - v2
Checksum:i890A6E57505B10A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288E → G in BAH11565 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293673 mRNA Translation: BAH11565.1
AL589765 Genomic DNA No translation available.
BC157847 mRNA Translation: AAI57848.1
BC171843 mRNA Translation: AAI71843.1
CCDSiCCDS44224.1
RefSeqiNP_001129475.1, NM_001136003.1
XP_011507357.1, XM_011509055.2
XP_016855478.1, XM_016999989.1
UniGeneiHs.694717

Genome annotation databases

EnsembliENST00000454109; ENSP00000389554; ENSG00000225556
GeneIDi100191040
KEGGihsa:100191040
UCSCiuc010pdq.2 human

Similar proteinsi

Entry informationi

Entry nameiC2D4D_HUMAN
AccessioniPrimary (citable) accession number: B7Z1M9
Secondary accession number(s): B2RXG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 12, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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