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Entry version 91 (29 Sep 2021)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Inactivation no afterpotential E, isoform E

Gene

inaE

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-426048, Arachidonate production from DAG

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inactivation no afterpotential E, isoform EImported (EC:3.1.1.34Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:inaEImported
Synonyms:CG11096Imported, CG11102Imported, CG11104Imported, CG15761Imported, CG32630Imported, DAGLImported, Dmel\CG33174Imported, EP(X)1101Imported
ORF Names:CG33174Imported, Dmel_CG33174Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261244, inaE

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0261244

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 43HelicalSequence analysisAdd BLAST26
Transmembranei55 – 81HelicalSequence analysisAdd BLAST27
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Transmembranei134 – 157HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B7Z150

PRoteomics IDEntifications database

More...
PRIDEi
B7Z150

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261244, Expressed in egg chamber and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B7Z150, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B7Z150, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0288741

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini400 – 535Lipase_3InterPro annotationAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni691 – 734DisorderedSequence analysisAdd BLAST44
Regioni1030 – 1089DisorderedSequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi694 – 711Polar residuesSequence analysisAdd BLAST18
Compositional biasi1032 – 1068Polar residuesSequence analysisAdd BLAST37

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2088, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_260117_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B7Z150

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B7Z150

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR002921, Fungal_lipase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01764, Lipase_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

B7Z150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGLVVFRRR WSVGSDDLVV PGAFLLTIHF ICFVIVSVSL VIFEYNTRIL
60 70 80 90 100
SVKLLFYHLI GYLLILFFSI CVEIGICVIS MRGSILDAEA RTSINIWIYL
110 120 130 140 150
KSLVILFDIA WLAVGSVWLG HYYTTAPIDD PKKVYIAIII CNWALVVITL
160 170 180 190 200
ITIWCTFDAA GRSWVKMKKY QRSMRETESR FNYKRSNSMN RNWRQRKVMR
210 220 230 240 250
AYQDSWDHRC RLLFCCMGSS ERNRNSFTDI ARLLSDFFRE LDVVPSDVVA
260 270 280 290 300
GLVLLRKFQR LEREAIVRQR KNGTYEFLSG VPITERTQFL ALNDAKNYDF
310 320 330 340 350
FQTVIHYMYF AQGAYGWPMY VIINRSKMWH LVPELKCFGC CCGTSDDTEV
360 370 380 390 400
IQDNCCLCNY AALKKTLQLG DIDIVYATYH VDVGETPFFV AIDYTHRAVV
410 420 430 440 450
ISIRGTLSMK DILTDLNAEG EVLPLQPPRD DWLGHKGMVQ AAIYIRNKLQ
460 470 480 490 500
EENLIERALQ RNPDRQTHTF DLVLVGHSLG AGTAAILAIL LKPEHPTLQC
510 520 530 540 550
FSYSPPGGLL SMPAVEYSKS FITSVVLGKD VVPRIGLNQM EALRADLINA
560 570 580 590 600
IQRSVDPKWK TISCSVICCG CGPEPTSVVN MSGQDTHINQ YQEERGTARS
610 620 630 640 650
TSAHPTDSSI ALTLHQPLYP PGRIIHIVRH HPKPDEQKYD SGWRNVLKNR
660 670 680 690 700
EPVYQAIWAD STDFDEVLIS PVMLQDHMPD KVLAALKKVV TTSGPRKPQR
710 720 730 740 750
QTSNAFSTGS NEAAHDMDLE PPHCSGHSAP TDAMRFETRT DPGQMQNSMS
760 770 780 790 800
QSQHCKRLSQ SSYTNLSNCL VLTPTAQHKL CLETSFTNGS TPHQSGVQPN
810 820 830 840 850
PRLTSAASSL LSSATTPYDI SSALDDSLAT VALRQSPSLI SAETTATVIV
860 870 880 890 900
NPEPDAEEIA IPQRLKAVAF DMALTPPPTL PERSMLGRQH SEKKPRSLPL
910 920 930 940 950
AQVQALRRAS DAGAVPGVDL LHDDWYGLAP LASPETLSEI SSVSSRTSVP
960 970 980 990 1000
ISLANSIERY LQHMGVGVGG PKVPLEDIFE SQLHTPKVMR RAPKFSENLA
1010 1020 1030 1040 1050
GCAEDTRNLD QYKRLGRVFI TFPRIFPDQS PAAHSLDSSD DSFESASAHS
1060 1070 1080 1090 1100
LQRLQLPHGA NAVQSSKSAD PLDGDPDATR QTQPAKKLTF SDSDILTDAD
1110 1120 1130 1140 1150
CLRLCPHCPC DRDVQRGCCT RSEHGKCGTE ISGGCGGAAM GLGSTDTSFY
1160 1170 1180 1190 1200
SASSSLEQFA TPARQNGGTG ASGNHLEEIL IRPGVLESHF PVLGGGSAIE
1210 1220 1230 1240 1250
TPALVAPASP SPLSNGKRPD VVGGRVRKRL SSEEFVFSRS EDLPSLVQIG
1260 1270 1280 1290 1300
DRCTGSPAGR RRAKGCVYPA GNSLRLDAAA AVASASASPT SISKFTRTRV
1310
AAGGLAAKQA AGNNESNV
Length:1,318
Mass (Da):144,895
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0135B72919832D59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JBS2X2JBS2_DROME
Inactivation no afterpotential E, i...
inaE CG11096, CG11102, CG11104, CG15761, CG32630
1,310Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86B55Q86B55_DROME
Diacylglycerol lipase isoform D
inaE CG11096, CG11102, CG11104, CG15761, CG32630
737Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JDP4X2JDP4_DROME
Inactivation no afterpotential E, i...
inaE CG11096, CG11102, CG11104, CG15761, CG32630
729Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z151B7Z151_DROME
Inactivation no afterpotential E, i...
inaE CG11096, CG11102, CG11104, CG15761, CG32630
815Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8MR12Q8MR12_DROME
Diacylglycerol lipase isoform A
inaE CG11096, CG11102, CG11104, CG15761, CG32630
644Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ACL82927.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138195.1, NM_001144723.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0290302; FBpp0288741; FBgn0261244

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33174

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ACL82927.1
RefSeqiNP_001138195.1, NM_001144723.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0288741

Proteomic databases

PaxDbiB7Z150
PRIDEiB7Z150

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
32343

Genome annotation databases

EnsemblMetazoaiFBtr0290302; FBpp0288741; FBgn0261244
GeneIDi32343
KEGGidme:Dmel_CG33174

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32343
FlyBaseiFBgn0261244, inaE
VEuPathDBiVectorBase:FBgn0261244

Phylogenomic databases

eggNOGiKOG2088, Eukaryota
HOGENOMiCLU_260117_0_0_1
InParanoidiB7Z150
PhylomeDBiB7Z150

Enzyme and pathway databases

ReactomeiR-DME-426048, Arachidonate production from DAG

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
32343, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32343

Gene expression databases

BgeeiFBgn0261244, Expressed in egg chamber and 43 other tissues
ExpressionAtlasiB7Z150, baseline and differential
GenevisibleiB7Z150, DM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002921, Fungal_lipase-like
PfamiView protein in Pfam
PF01764, Lipase_3, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7Z150_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7Z150
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 29, 2021
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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