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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borreliella garinii PBr
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei620ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:BGAPBR_0257Imported
OrganismiBorreliella garinii PBrImported
Taxonomic identifieri498743 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000006103 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 177tRNA-synt_1gInterPro annotationAdd BLAST135
Domaini227 – 410tRNA-synt_1_2InterPro annotationAdd BLAST184
Domaini423 – 581tRNA-synt_1InterPro annotationAdd BLAST159
Domaini617 – 643tRNA-synt_1InterPro annotationAdd BLAST27
Domaini686 – 802Anticodon_1InterPro annotationAdd BLAST117

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi617 – 621"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B7XSS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKYEFIKIE KKWQEFWDNN KTYKVKEDPN IPKEKRLYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP
110 120 130 140 150
QKSTEENINK FKKQIKALGF AYDWDREIRT HDENYYKWTQ WIFLELYKKG
160 170 180 190 200
LAYAKEMPVW YCPELGTVLA NEEIIQTPDG PKSERGFHNV EKKYLRQWVL
210 220 230 240 250
KITKYAERLL NDLEELEWPE SVKEMQRNWI GKSTGVEIDF EIEGHNDKIT
260 270 280 290 300
VFTTRPDTIF GITYLVIAPE NKLIEKITKN NFKRNVLKYV KREELKSDLK
310 320 330 340 350
RTSLEKDKSG VFTGSYAFHP ITNEKIPIWV GSYVLGTYGS GAVMGVPAHD
360 370 380 390 400
ERDFQFAKKY KLKILPVISK SGKNEILEKA FIDDGISINS PNEFNNLKNS
410 420 430 440 450
EVKDKVIKWL IKNKKGKEKI TYKLRDWIFS RQRYWGEPIP ILFDKLGNAI
460 470 480 490 500
PLEKNDLPLK LPETANYKPS RTGESPLSRI KDWANLKDTG FTRETNTMPQ
510 520 530 540 550
WAGSCWYYLR YLDPKNPKEF ASKKKIEYWM PVDLYIGGAE HTVLHLLYSR
560 570 580 590 600
FWHKVLYDLG YVNTKEPFKK LINQGIITAF SYQKENGILI PNDQVIEKDN
610 620 630 640 650
KFFDKRDNKE VTQVIAKMSK SLKNVINPDD IIKEFGADSI RIYEMFMGPL
660 670 680 690 700
TDSKPWNTKG IIGVFRFLNK IWNLREKELS KDNPPKEIIS QLHKAIKKVT
710 720 730 740 750
EDTEKLNFNT AISAMMIFVN ELLKYEKNYL NIFKPFIIIL SPYAPHLAEE
760 770 780 790 800
LWEYIGETPS LFKNSKWPKF DENLIIKDAK EIVLQINGKI KDKILLSKET
810 820 830 840
DEEELKEIAM GNSKIKANLL NKKIVKIIAI KNKLVNIVIK
Length:840
Mass (Da):98,197
Last modified:March 3, 2009 - v1
Checksum:i686944538230D3DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABJV02000002 Genomic DNA Translation: EED28961.1
RefSeqiWP_004791606.1, NZ_ABJV02000002.1

Genome annotation databases

EnsemblBacteriaiEED28961; EED28961; BGAPBR_0257

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABJV02000002 Genomic DNA Translation: EED28961.1
RefSeqiWP_004791606.1, NZ_ABJV02000002.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEED28961; EED28961; BGAPBR_0257

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB7XSS4_BORGR
AccessioniPrimary (citable) accession number: B7XSS4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 12, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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