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Entry version 42 (11 Dec 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Huntingtin

Gene

Htt

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HuntingtinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HttImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B7XBM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati898 – 928HEATPROSITE-ProRule annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 77DisorderedSequence analysisAdd BLAST77
Regioni438 – 460DisorderedSequence analysisAdd BLAST23
Regioni506 – 598DisorderedSequence analysisAdd BLAST93
Regioni623 – 666DisorderedSequence analysisAdd BLAST44
Regioni1166 – 1215DisorderedSequence analysisAdd BLAST50
Regioni2623 – 2650DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 72Pro-richSequence analysisAdd BLAST49
Compositional biasi521 – 573PolarSequence analysisAdd BLAST53
Compositional biasi634 – 662PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1195 – 1215PolarSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZV Eukaryota
ENOG410XSEC LUCA

KEGG Orthology (KO)

More...
KOi
K04533

Database of Orthologous Groups

More...
OrthoDBi
33894at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat

The PANTHER Classification System

More...
PANTHERi
PTHR10170 PTHR10170, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12372 DUF3652, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00375 HUNTINGTIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7XBM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLEKLMKA FESLKSFQQQ QQQQQQPPPP PPPPPPPPPQ LPQPPPQAQP
60 70 80 90 100
LLPQPQPPPP PPPPPPGPAA AEEPLHRPKK ELSATKKDRV NHCLTICENI
110 120 130 140 150
VAQSVRNSPE FQKLLGIAME LLLLCSDDAE SDVRMVADEC LNKVIKALMD
160 170 180 190 200
SNLPRLQLEL YKEIKKNGAP RSLRAALWRF AELAHLVRPQ KCRPYLVNLL
210 220 230 240 250
PCLTRTSKRP EESVQETLAA AVPKIMASFG NFANDNEIKI LLKAFIANLK
260 270 280 290 300
SSSPTIRRTA AGSAVSICQH SRRTHYFYSW LLNVLLGLLV PVEDEHSTLL
310 320 330 340 350
ILGVLLTLRY LVPLLHQQVK DTSLKGSFGV TRKEMEVSPS AEQLIQVYEL
360 370 380 390 400
TLHHTQHQDH NVVTGALELL QQLFRTPPPE LLQALTTVGG IRQLTEAKDE
410 420 430 440 450
SGGRSRSGSI VELIAGGGSS CSPVLSRKQK GKVLLGEEEA LEDDSESRSD
460 470 480 490 500
VSSSAFAASV KDEISGELTA SSGVSTPGSA GHDIITEQPR SQHTLQADSV
510 520 530 540 550
DLAGCDLTSS ATDGDEEDIL SHSSSQVSAV PSDPAMDLND GTQASSPISD
560 570 580 590 600
SSQTTTEGPD SAVTPSDSSE IVLDGADNQY LGPQIGQPQD EDEEATSVLP
610 620 630 640 650
DEASEAFRNS SMALQQAHLL KNMSHSRQPS DSSVDKFVSR DEATESGDQE
660 670 680 690 700
SKPCRIKGDI GQSTDDDSAP LVHCVRLLSA SFLLTGGKNV LVPDRDVRVS
710 720 730 740 750
VKALALSCVG AAVALHPESF FSKLYKVPLD TADYPEEQYV SDILNYIDHG
760 770 780 790 800
DPQVRGATAI LCGTLVCSIL SRSRFHVGEW MGTIRTLTGN TFSLADCVPL
810 820 830 840 850
LRKTLKDESS VTCKLACTAV RHCVMSLCSS SYSELGLQLL IDLLTLRNSS
860 870 880 890 900
YWLVRTELLE TLAEIDFRLV SFLEAKAENL HRGAHHYTGL LTLQERVLTS
910 920 930 940 950
VVIHLLGDED PRVRHVAAAS LIRLVPKLFY KCDQGQADPV VAVARDQSSV
960 970 980 990 1000
YLKLLMHETQ PPSHFSVSTI TRIYRGYNLL PSIIDVTMEN NLSRVIAAVS
1010 1020 1030 1040 1050
HELITSTTRA LTFGCCEALC LLSTAFPVCI WSLGWHCGVP PLSASDECRK
1060 1070 1080 1090 1100
SCTIGMATMI LTLLSSAWFP LDLSAHQDAL ILAGNLLAAS APKSLRSSWT
1110 1120 1130 1140 1150
SEEEANPAAT KQEEVWPALG DRALVPMVEQ LFSHLLKVIN ICAHVLDDVA
1160 1170 1180 1190 1200
PGPAIKAALP SLTNPPSLSP IRRKGKEKEP GEQASVPLSP KKGSEASAAS
1210 1220 1230 1240 1250
RQSDTSGPVT TSKSSSLGSF YHLPSYLKLH DVLKATHANY KVTLDLQNST
1260 1270 1280 1290 1300
EKFGGFLRSA LDVLSQILEL ATLQDIGKCV EEILGYLKSC FSREPMMATV
1310 1320 1330 1340 1350
CVQQLLRTLF GTNLASQFDG LSSNPSKSQG RVQRLGSSSV RPGLYHYCFM
1360 1370 1380 1390 1400
APYTHFTQAL ADASLRNMVQ AEQEHDTSGW FDVLQKVSTQ LKTNLTSVTK
1410 1420 1430 1440 1450
NRADKNAIHN HIRLFEPLVI KALKQYTTTT SVQLQKQVLD LLAQLVQLRV
1460 1470 1480 1490 1500
NYCLLDSDQV FIGFVLKQFE YIEVGQFRES EAIIPNIFFF LVLLSYERYH
1510 1520 1530 1540 1550
SKQIIGIPKI IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF VLRGANKADA
1560 1570 1580 1590 1600
GKELETQKEV VVSMLLRLIQ YHQVLEMFIL VLQQCHKENE DKWKRLSRQI
1610 1620 1630 1640 1650
ADIILPMLAK QQMHIDSHEA LGVLNTLFEI LAPSSPRPVD MLLRSMFVTP
1660 1670 1680 1690 1700
NTMASVSTVQ LWISGILAIL RVLISQSTED IVLSRIQELT FSPYLISCPV
1710 1720 1730 1740 1750
ISRLRDGDSN SALEEHSEGK QIKTLPEETF SRFLLQLVGI LLEDIVTKQL
1760 1770 1780 1790 1800
KVEMSEQQHT FYCQELGTLL MCLIHIFKSG MFRRITAAAT RLFRSDGCGG
1810 1820 1830 1840 1850
SFYTLESLNL RARSMITTHP TLVLLWCQIL PLVNHTDYRW WAEVQQTPKR
1860 1870 1880 1890 1900
HSLSSTKLLS PQMSGEEEDS DLAAKLGMCN REIVRRGALI LFCDYVCQNL
1910 1920 1930 1940 1950
HDSEHLTWHI VNHIQDLISL SHEPPVQDFI SAVHRNSAAS GLFIQAIQSR
1960 1970 1980 1990 2000
CENLSTPTTL KKTLQCLEGI HLSQSGAVLT LYVDRLLCTP FRVLARMVDI
2010 2020 2030 2040 2050
LACRRVEMLL AANLQSSMAQ LPMEELNRIQ EYLQSSGLAQ RHQRLYSLLD
2060 2070 2080 2090 2100
RFRLSTLQDS LSPSPPVSSH PLDGDGHVSL ETVSPDKDWY IHLVKSQCWT
2110 2120 2130 2140 2150
RSDSALLEGA ELVNRIPAED MSAFMMNSEF NISLLAPCLS LGMSEISGGQ
2160 2170 2180 2190 2200
KSPLFEAARE VTLARVSGTV QRLPAVHHVF QPHLPAEPAA YWSKLNDLFG
2210 2220 2230 2240 2250
DAALYQSLTT LARALAQYLV VVSKLPTHLH LPPEKEKDTV KFVVATLEAL
2260 2270 2280 2290 2300
SWHLIHEQIP LSLDLQAGLD CCCLALQLPG LWSVISSTEF VTHACSLIHC
2310 2320 2330 2340 2350
VHFILEAVAV QPGEQLLSPE RRRNTPKAIR EEEEVDANTQ NPKYITAACE
2360 2370 2380 2390 2400
MVAEMVESLQ SVLALGHKRN SSVPAFLTSV LRNIIVSLAR LPLVNSYTRV
2410 2420 2430 2440 2450
PPLVWKLGWS PKPGGEFGTA FPEIPVEFLQ EKEVFKEFIY RINTLGWTSR
2460 2470 2480 2490 2500
TQFEETWATL LGVLVTQPLV MEQEESPPEE DTERTQINVL AVQAITSLVL
2510 2520 2530 2540 2550
SAMTVPVAGN PAVSCLEQQP RNKPLKALDT RFGRKLSIIR GIVEQEIQAM
2560 2570 2580 2590 2600
VSKRENIATH HLYQAWDPVP SLSPATTGAL ISHEKLLLQT NPERELGSMS
2610 2620 2630 2640 2650
YKLGQVSIHS VWLGNNITPL REEEWGEEEE EEADTPAPSS PPTSPVNSRK
2660 2670 2680 2690 2700
HRAGVDIHSC SQFLLELYSR WILPSSSARR TPAILISEVV RSLLVVSDLF
2710 2720 2730 2740 2750
TERSQFELMY VTLTELRRVH PSEDEILAQY LVPATCKAAT VLGMDKAVAE
2760 2770 2780 2790 2800
PVSRLLESTL RSSHLPSRVG ALHGILYVLE CDLLDDTAKQ LIPVISDYLL
2810 2820 2830 2840 2850
SSLKGLAHCV NTHSQQHVLV MCATAFYLIE NYPLDVGPEF SASIIQTCGV
2860 2870 2880 2890 2900
MLSGSEESTP SIIYHCALRG LERLLLSEQL SRLDAESLVK LSVDRVNVHS
2910 2920 2930 2940 2950
PHRAMAALGL MLTCMYTGKE KISPGRTSDP NPAAPDSESV IVAMERVSVL
2960 2970 2980 2990 3000
FDRIRKGFPC EARVVARILP QFLDDFFPPQ DIMNKVIGEF LSNQQPYPQF
3010 3020 3030 3040 3050
MATVVYKVFQ TLHSTGQSSM VRDWVMLSLS NFTQRTPVAM AMWSLSCFFV
3060 3070 3080 3090 3100
SASTSPWVAA ILPHVISRMG KLEQVDVNLF CLVATDFYRH QIEEELDRRA
3110 3120 3130
FQSVFEMVAA PGSPYHRLLT CLRNVHKVTT C
Length:3,131
Mass (Da):346,333
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A1B09901F5AFC3E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB443866 mRNA Translation: BAH03657.1

NCBI Reference Sequences

More...
RefSeqi
NP_001254674.1, NM_001267745.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100403524

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cjc:100403524

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB443866 mRNA Translation: BAH03657.1
RefSeqiNP_001254674.1, NM_001267745.1

3D structure databases

SMRiB7XBM1
ModBaseiSearch...

Genome annotation databases

GeneIDi100403524
KEGGicjc:100403524

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3064

Phylogenomic databases

eggNOGiENOG410IDZV Eukaryota
ENOG410XSEC LUCA
KOiK04533
OrthoDBi33894at2759

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat
PANTHERiPTHR10170 PTHR10170, 1 hit
PfamiView protein in Pfam
PF12372 DUF3652, 1 hit
PRINTSiPR00375 HUNTINGTIN
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7XBM1_CALJA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7XBM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 11, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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