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Entry version 30 (16 Jan 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Heavy metal efflux pump, CzcA family

Gene

CtesDRAFT_PD2977

Organism
Comamonas testosteroni (strain DSM 14576 / KF-1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CTES399795:G10SR-3009-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Heavy metal efflux pump, CzcA familyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CtesDRAFT_PD2977Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiComamonas testosteroni (strain DSM 14576 / KF-1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri399795 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000003039 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei339 – 356HelicalSequence analysisAdd BLAST18
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei389 – 410HelicalSequence analysisAdd BLAST22
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei471 – 498HelicalSequence analysisAdd BLAST28
Transmembranei519 – 546HelicalSequence analysisAdd BLAST28
Transmembranei864 – 883HelicalSequence analysisAdd BLAST20
Transmembranei890 – 909HelicalSequence analysisAdd BLAST20
Transmembranei921 – 941HelicalSequence analysisAdd BLAST21
Transmembranei962 – 981HelicalSequence analysisAdd BLAST20
Transmembranei993 – 1016HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
399795.CtesDRAFT_PD2977

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108IJF Bacteria
COG3696 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004763 CzcA/CusA/SilA/NccA/HelA/CnrA

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00914 2A0601, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7WYS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSRLIEFSL RQRALVLLGV LALAGAGLAA FLQLPIDAYP DISPTQVKLI
60 70 80 90 100
IKAPGMTPEE VESRVITPLE MELLGVPRGV MLRSTAKYAI ADITLDFAEG
110 120 130 140 150
SDIYWARQQV AERYAGVSGS LPDGVSGGLA PISTPLSDVF MFTIEGGSLT
160 170 180 190 200
LSERRALLDW TLRPALRTLP GVADVNVLGG EAKSFAVVPD RARLSAAGLG
210 220 230 240 250
FSDVITAISR NNRNDGAGRL DAGEDTLIVR AEGAIHTLDD LSRLILRAGA
260 270 280 290 300
NGTAPVRLGD VAQVRIEGVT RYGAVTRDGA GEAVEGIVVA LRGADASALV
310 320 330 340 350
KAIRARLDEV APSLPPGVKV VPFYDRSTLI ERAVGTVESA LLEATVLVVI
360 370 380 390 400
LLLLFLGELR AALVVAVMVP LAALGTFLLM RLVGMSANLM SLGGLAIAIG
410 420 430 440 450
MLVDAAVVVV ENAVSRLDPH APSAHQPRLH RIFAAAREVA MPVASGILII
460 470 480 490 500
CLTFMPLLTL QGLEGKLFVP VALTIVFALG VSLLLSLTLV PVLASLLLKE
510 520 530 540 550
HTHTEPWVMR WATRLYQPLL EAALHHPLRA SAVAIAALAL GVVAYLGTGK
560 570 580 590 600
AFMPTMDEGD ILLQLQKPPS IGLQRSLEID LAVQKAIGAA VPEVRHSIGR
610 620 630 640 650
VGSDELGLDP MGLNETDLFM QLAPRKDWHA ADKDALSAEI RKVMDAFPGL
660 670 680 690 700
EFGFTQPIEM RISEMLTGSR GDVAVKLFGP DLQTLGDLAQ RMAARIEKVP
710 720 730 740 750
GARDVLTQAS DSVEYLQVKV DAQAAGRAGL AVTQVQDELR AQLEGVPAGL
760 770 780 790 800
VIEPDRRTPI VVRGDARLRG SAERFKDLQL ARGDQGEIPL ASLARIATTD
810 820 830 840 850
GPVLVRRENG SRFALIQSSV SGRDLVGFVD EAREAVARDV PLPPGYRVEW
860 870 880 890 900
GGQFENQQRA AARLGMVVPV ALGLIFFVLF MTFGSVRQAA LILGNVPFAM
910 920 930 940 950
VGGVAALWLS GQYLSVPASV GFIALLGIAV LNGLVLVTHF NHLHALGLPM
960 970 980 990 1000
EQVVREGSLR RLRPVLMTAS ITAFGLVPLL LASGPGSEIQ RPLAIVVIGG
1010 1020 1030
LVSSTALTLV LLPVLYRRFG QAISSQQGVH A
Length:1,031
Mass (Da):109,370
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA19B842F2CAEB51
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAUJ02000001 Genomic DNA Translation: EED68031.1

NCBI Reference Sequences

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RefSeqi
WP_003056159.1, NZ_AAUJ02000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
EED68031; EED68031; CtesDRAFT_PD2977

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAUJ02000001 Genomic DNA Translation: EED68031.1
RefSeqiWP_003056159.1, NZ_AAUJ02000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi399795.CtesDRAFT_PD2977

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEED68031; EED68031; CtesDRAFT_PD2977

Phylogenomic databases

eggNOGiENOG4108IJF Bacteria
COG3696 LUCA

Enzyme and pathway databases

BioCyciCTES399795:G10SR-3009-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004763 CzcA/CusA/SilA/NccA/HelA/CnrA
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits
TIGRFAMsiTIGR00914 2A0601, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7WYS0_COMTK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7WYS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 16, 2019
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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