Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 91 (16 Jan 2019)
Sequence version 1 (10 Feb 2009)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Protein shank

Gene

shn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions (PubMed:28477407). Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca2+ current density (PubMed:28477407). The maintenance of Ca2+ also allows for the downstream regulation of Ca2+-induced expression of genes such as gem-4 (PubMed:28477407). Plays a role in the regulation of the defecation cycle, and this may be in association with the inositol trisphosphate (IP3) receptor itr-1, which in turn mediates periodic calcium release and muscle contractions (PubMed:15013747, PubMed:21191812). Required for normal fertility and pharyngeal pumping (PubMed:21191812).3 Publications

Miscellaneous

In contrast to the mammalian Shank proteins, does not contain a SH3 domain.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • defecation Source: WormBase
  • rhythmic behavior Source: WormBase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein shank1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shn-11 PublicationImported
ORF Names:C33B4.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C33B4.3a ; CE01508 ; WBGene00006444 ; shn-1
C33B4.3b ; CE36107 ; WBGene00006444 ; shn-1
C33B4.3c ; CE43434 ; WBGene00006444 ; shn-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Animals are viable, but produce a reduced brood size, have a prolonged defecation cycle and a reduced pharyngeal pumping rate as compared to wild-type (PubMed:21191812). Reduced male fertility which may be due to irregular male mating behavior and defective sperm function (PubMed:21191812). Reduced cell surface abundance of the L-type egl-19 calcium channel in body wall muscles, which results in a 20% decrease in Ca2+ current density (PubMed:28477407). In response to the nicotinic acetylcholine agonist levamisole, there is reduced expression of genes such as gem-4 (PubMed:28477407). Irregular postsynaptic transmission at neuromuscular junctions characterized by larger stimulus-evoked excitatory postsynaptic currents as compared to wild-type (PubMed:28477407). RNAi-mediated knockdown results in viable animals with no visible phenotype (PubMed:15013747). However, there is a slight reduction in brood size, but there are no visible defects in terms of embryonic viability, growth or morphology in their resulting progeny (PubMed:15013747). RNAi-mediated knockdown in an itr-1(sa73) loss of function mutant background results in a longer defecation cycle as compared to the itr-1 single mutant (PubMed:15013747).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004417371 – 1140Protein shankCuratedAdd BLAST1140

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B7WN72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B7WN72

PeptideAtlas

More...
PeptideAtlasi
B7WN72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pharynx, pharyngeal-intestinal valve, intestine, rectal epithelial cells, tail neurons, nerve cord and sperm.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development from embryos to adults. Highly expressed in the nerve cord of embryos. Expressed in vulval epithelial cells of L4 stage hermaphrodites.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006444 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PDZ domain) with egl-19 (via C-terminus).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_H06I04.1Q8MXV32EBI-2914750,EBI-2422468

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
B7WN72, 19 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C33B4.3c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B7WN72

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B7WN72

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati144 – 174ANK 1Sequence analysisAdd BLAST31
Repeati178 – 207ANK 2Sequence analysisAdd BLAST30
Repeati211 – 242ANK 3Sequence analysisAdd BLAST32
Repeati246 – 275ANK 4Sequence analysisAdd BLAST30
Repeati279 – 309ANK 5Sequence analysisAdd BLAST31
Repeati312 – 341ANK 6Sequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini436 – 529PDZPROSITE-ProRule annotationAdd BLAST94
Domaini1078 – 1140SAMPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi718 – 846Pro-richPROSITE-ProRule annotationAdd BLAST129

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SHANK family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016844

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B7WN72

KEGG Orthology (KO)

More...
KOi
K15009

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGLTKHV

Database of Orthologous Groups

More...
OrthoDBi
151556at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF00536 SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform cImported (identifier: B7WN72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQEEDTVNL QIFVPELNVR KFLAVTQNDF IWDVKRKLLA TLPQALPQAF
60 70 80 90 100
NYGLFLPPCD GRAGKFLLED RTIRDYPFTD CVPYLELKYK KRVYKMLNLD
110 120 130 140 150
EKQLKAMHTK GQLKKFMDYV QQKNNEKVEK MCSQGLDANF HDAQGETPLT
160 170 180 190 200
LAAGIPNNRA VIVSLIGGGA HVDFRNSEGQ TAMHKAAFLS SFENVKTLIE
210 220 230 240 250
LGASPNYRDP IGLTPLYYNM LTADSNDQVA EILLREAADI GVTDMHGNHE
260 270 280 290 300
IHQACKNGLT KHVEHLLYFG GQIDAENVNG NSPLHVCAVN NRPECARVLL
310 320 330 340 350
FRGADHLAVN KQGQTALHVS HIVGNPGVAD VVQAHNPKSS VPYRGTPQYS
360 370 380 390 400
TRRRLSSTIT RRRSMSQSSI CSQDVYRTPQ SVRKGPMSAA PSPSPSRSSR
410 420 430 440 450
TTITPSEYGT MRRSGMDSMR GGGMIAAGHE TNIARILVIP RGVKGFGFIL
460 470 480 490 500
RGAKHVAMPL NFEPTAQVPA LQFFEGVDMS GMAVRAGLRP GDYLLEIDGI
510 520 530 540 550
DVRRCSHDEV VEFIQQAGDT ITLKVITVDV ADMSRGGTIV HRPPTASSRH
560 570 580 590 600
SLVFTPTPSA IYSSTKASSV YRMRFDTHDA HGVDYYAPNE IRNAYSESRH
610 620 630 640 650
ASVRQRPGSG RRISAAELEN LMVRQRVPSV QGSPYQMQYD QESLNGGYSS
660 670 680 690 700
KKYNSVSDMK RRKGQRNVVA SSAGLNRSTF EQAAPTTSTF EYNCSSRSTP
710 720 730 740 750
QLSRMDSFDS FDDEDEMPAP PPASYISPDL QRDSSMQRSE YSRPFRPTSR
760 770 780 790 800
PKTPPPPPPM QHQNHQNHQY QQQHPSLPRS ASTPQPIQQQ QSSIPPPPPP
810 820 830 840 850
PPPPHCEPTM VHVEFTPPST SSVPPPPPPL PPISSGAPPP PPPPPPGGLM
860 870 880 890 900
HVAASAPVLM SNSKGISADA LKSVQLKKAE PRETSAASVS NNNNNNNNST
910 920 930 940 950
TDFQMDLKNA LAKRRSKVAH DVDEDEERES RFEGLSLRET VRENVVERGK
960 970 980 990 1000
GIQNIGIVNK KDSGYTSSRT SLEPSESEEK DHRPHFSLDH SPNVQRVTLI
1010 1020 1030 1040 1050
SQHLEDNYGQ KDNMSVASSS TASSSSTVDL TKPGCFVVPS HVIPPVDYDD
1060 1070 1080 1090 1100
DPDSGTGDSD GEIRCSEISF EHKKVDVWSV DDVIGWLSSL HLSEYTPAFR
1110 1120 1130 1140
SQRINGRCLR QCDRSRFTQL GVTRIAHRQI IESALRGLLQ
Length:1,140
Mass (Da):125,946
Last modified:February 10, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE17B1F5BC5CC8DF
GO
Isoform aImported (identifier: B7WN72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-575: Missing.

Show »
Length:1,110
Mass (Da):122,629
Checksum:i89A21494B8ED43DB
GO
Isoform bImported (identifier: B7WN72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-575: Missing.
     1014-1023: MSVASSSTAS → VVKYHSNTRR
     1024-1140: Missing.

Show »
Length:993
Mass (Da):109,904
Checksum:i1AFE2812954A4866
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059097546 – 575Missing in isoform a and isoform b. CuratedAdd BLAST30
Alternative sequenceiVSP_0590981014 – 1023MSVASSSTAS → VVKYHSNTRR in isoform b. Curated10
Alternative sequenceiVSP_0590991024 – 1140Missing in isoform b. CuratedAdd BLAST117

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA88324.1
BX284602 Genomic DNA Translation: CAE54886.1
BX284602 Genomic DNA Translation: CAV31765.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19673

NCBI Reference Sequences

More...
RefSeqi
NP_001022006.1, NM_001026835.3 [B7WN72-2]
NP_001022007.1, NM_001026836.3 [B7WN72-3]
NP_001254297.1, NM_001267368.1 [B7WN72-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.6411

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C33B4.3a; C33B4.3a; WBGene00006444 [B7WN72-2]
C33B4.3b; C33B4.3b; WBGene00006444 [B7WN72-3]
C33B4.3c; C33B4.3c; WBGene00006444 [B7WN72-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174739

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C33B4.3

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA88324.1
BX284602 Genomic DNA Translation: CAE54886.1
BX284602 Genomic DNA Translation: CAV31765.1
PIRiT19673
RefSeqiNP_001022006.1, NM_001026835.3 [B7WN72-2]
NP_001022007.1, NM_001026836.3 [B7WN72-3]
NP_001254297.1, NM_001267368.1 [B7WN72-1]
UniGeneiCel.6411

3D structure databases

ProteinModelPortaliB7WN72
SMRiB7WN72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7WN72, 19 interactors
STRINGi6239.C33B4.3c

Proteomic databases

EPDiB7WN72
PaxDbiB7WN72
PeptideAtlasiB7WN72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC33B4.3a; C33B4.3a; WBGene00006444 [B7WN72-2]
C33B4.3b; C33B4.3b; WBGene00006444 [B7WN72-3]
C33B4.3c; C33B4.3c; WBGene00006444 [B7WN72-1]
GeneIDi174739
KEGGicel:CELE_C33B4.3

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174739
WormBaseiC33B4.3a ; CE01508 ; WBGene00006444 ; shn-1
C33B4.3b ; CE36107 ; WBGene00006444 ; shn-1
C33B4.3c ; CE43434 ; WBGene00006444 ; shn-1

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000153561
HOGENOMiHOG000016844
InParanoidiB7WN72
KOiK15009
OMAiNGLTKHV
OrthoDBi151556at2759

Enzyme and pathway databases

ReactomeiR-CEL-6794361 Neurexins and neuroligins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B7WN72

Gene expression databases

BgeeiWBGene00006444 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHANK_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7WN72
Secondary accession number(s): Q09493, Q7JMK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2017
Last sequence update: February 10, 2009
Last modified: January 16, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again