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Entry version 92 (18 Sep 2019)
Sequence version 5 (20 Dec 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

unc-68

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi4209 – 4220PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi4244 – 4255PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-68Imported
ORF Names:CELE_K11C4.5Imported, K11C4.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
K11C4.5b ; CE52133 ; WBGene00006801 ; unc-68

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4450 – 4473HelicalSequence analysisAdd BLAST24
Transmembranei4636 – 4653HelicalSequence analysisAdd BLAST18
Transmembranei4699 – 4721HelicalSequence analysisAdd BLAST23
Transmembranei4837 – 4859HelicalSequence analysisAdd BLAST23
Transmembranei4879 – 4904HelicalSequence analysisAdd BLAST26
Transmembranei4964 – 4983HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B7WN66

PeptideAtlas

More...
PeptideAtlasi
B7WN66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006801 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B7WN66 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 158MIRInterPro annotationAdd BLAST55
Domaini165 – 209MIRInterPro annotationAdd BLAST45
Domaini218 – 273MIRInterPro annotationAdd BLAST56
Domaini279 – 336MIRInterPro annotationAdd BLAST58
Domaini344 – 402MIRInterPro annotationAdd BLAST59
Domaini582 – 803B30.2/SPRYInterPro annotationAdd BLAST222
Domaini1006 – 1214B30.2/SPRYInterPro annotationAdd BLAST209
Domaini1477 – 1696B30.2/SPRYInterPro annotationAdd BLAST220
Domaini4196 – 4231EF-handInterPro annotationAdd BLAST36
Domaini4234 – 4266EF-handInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1328 – 1496DisorderedSequence analysisAdd BLAST169
Regioni3483 – 3503DisorderedSequence analysisAdd BLAST21
Regioni4540 – 4582DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1026 – 1046Sequence analysisAdd BLAST21
Coiled coili4483 – 4505Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1344 – 1381PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1391 – 1428PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1435 – 1456PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1457 – 1481PolarSequence analysisAdd BLAST25
Compositional biasi4562 – 4581PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168850

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231428

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

B7WN66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKEEQGGG EQDDVSFLRT GDIVCLSCVA SHNRDGVLGS ERVCLCTEGF
60 70 80 90 100
GNRMCTLENV SDKDIPPDIA MCMLYIDNAL SMRALQEMMS ADSDHKSASG
110 120 130 140 150
AGGHKTLLYG HAVQLKHVQS EMYLACLSSC SSNDKLAFDV GVQETNEGEA
160 170 180 190 200
CWWTIHPASK QRSEGEKVRV GDDVILVSVA TERYLHMAYS KGYMVIASFH
210 220 230 240 250
QTLWNIQSVS SGSMRTRNMG FLFGNDVLRL FHGNDECLTI PENWSEHPQH
260 270 280 290 300
NMVIYEGGAA VTQARSLWRV ELIRMKWHGA LVGWEQVFRI KHITSGRYLG
310 320 330 340 350
VLDNSVQLYH KEKADFDLTA FVMCQNKDPK KQMLDEKEEE GMGNATIRYG
360 370 380 390 400
ETNAFIQHVK TQLWLSYQTT EVTKKGLGKV EEKKAVALKD GHMDDCYTFF
410 420 430 440 450
MALEEESKSA RVIRKCSSVL NKFLKGIDAL QLEGNQSTDW TRVDLNEVLK
460 470 480 490 500
LMEDLIEYFA QPNDEQDFEE KQNHLRALRS RQDLFQEEGV LNMILDTIDK
510 520 530 540 550
FSQMEALPDF AGLIGEETHV KWEQISTYLY LLVAAMIKGN HYNCAQFASA
560 570 580 590 600
QRLDWLFGRL SNPQSAEGIL DVLYCVLTES PEALNMINEG HIRSVISLLE
610 620 630 640 650
KVGRDPKVLD VLSSLCEGNG MAVRSSQNLI TQYLLPGKDL LLQTSMRDHV
660 670 680 690 700
SSMMPNVMLG VVEGSALFRK WYFEAEVEHI ETMTKQTPYL RIGWANSVGF
710 720 730 740 750
KPFPGSGDKM GCNGVGDDFY SYGFDGKSMY FGGKSRRVGH KLLEKGDVIG
760 770 780 790 800
CSIDLTIPEI KFSVNGTYMS GSFKKFNIDG YFFPVMSLSA KVSCRFILGG
810 820 830 840 850
NQGRLRYGPP TGFSAVVEAV NGELQITDCL SFGDLGKNIF SGPQTIFNNL
860 870 880 890 900
EPFIPTPIDV SATQLNHHAT EMHQKYAENL HELWAMRKIE LGWSYGETRS
910 920 930 940 950
ETSRKHPCLT KFEYLPETEK KYNILLALTT MKTIEALGYH LITEDPPCRL
960 970 980 990 1000
RAVRLGPNFQ QQNGYKPGPL DTHEIQLPAE LQPLTEALAR NTHNIWAKEK
1010 1020 1030 1040 1050
IKRGWTFGLS EHVDATQKRS PHLVPYEQVD ERIKQANRES AAENIRALQL
1060 1070 1080 1090 1100
FGIFLEPPAH EHDEVAEKEL RARKDNTRTY RAEATYAVCG GKWYFEFEIL
1110 1120 1130 1140 1150
TAGYMKIGWM DIGSTPEIQL GADDRSYAFD GYLGRKWHQG AETYGKEWKI
1160 1170 1180 1190 1200
GDVVGCFLDL NDRTISFSLN GELLLDPSGS EMAFDNVVCG DGLVPAMTLG
1210 1220 1230 1240 1250
SGQRGRLNFG QQSNSLKFFT TCGLQEGYEP FCVNMYRTMP MWFAKQLPRF
1260 1270 1280 1290 1300
EDISTLKSGS ILEVSRIPAT GNSPPCLKIL QKVTISEGGP SEKAKMEYIK
1310 1320 1330 1340 1350
LSLPVKCNDT FVKNKDKETI RRQLQEYKPR SQSVVSQIRA PGIPKEFDDN
1360 1370 1380 1390 1400
KEKKGFLRSM LGSKDSHESD DDRRSRTNSK QPSVDGDEPP AVRRSLLELP
1410 1420 1430 1440 1450
HDERQIAEDS MRDLNDRHSE KPKKGGLLSR LRDSSNTRKN FRDSDRRKEE
1460 1470 1480 1490 1500
KAAQLRQMKA NSRSFDAGSL DTSTLPTGQK DVLASSEMPL SGPGRQLTIK
1510 1520 1530 1540 1550
RSSIKKNKKG KKAEIALEKM EREKKGSIIP MDAQLDVLQE GDAHALVHHK
1560 1570 1580 1590 1600
DKVDEYYYGI RIFPGQDPSQ VWVGWVTTQY HYYNVNFDGS QGVRKCRFSE
1610 1620 1630 1640 1650
ADHHGTTVDS VQSQNCYMVN VSELLATTPD VANTKVSGTL IGCIIDTSIG
1660 1670 1680 1690 1700
ELSFQVGSTD TGIKFKLEPG AMLFPAAFVT PTATEILQFE LGRIKYTFPL
1710 1720 1730 1740 1750
SAAMFKSCEK SLVPFCPPRL TVEQIESVYW ARVPNETLRT TALKLSEVRG
1760 1770 1780 1790 1800
WSVLCNDPVR IMSVYIPEKD QSLDILEMIE MPDMLEFHRQ TLNLYCKLAS
1810 1820 1830 1840 1850
HGNHKVAHTL CQHIDEDQIM YAIKSHYLSG PMRQGFHDLL IGLHLMSHTA
1860 1870 1880 1890 1900
ARNSMAKEYV IPLVPQLQIK NVLDPDSESR YPQITGESVS MLSQMASEPV
1910 1920 1930 1940 1950
KKHVSREDEM KLLPPSVDFE ALKKHVMESL QSATHHAVMN CRDLIGGDNT
1960 1970 1980 1990 2000
NHFEPLFKLF DQLLVIGLIN DEELECLLRL IHPQAFDENY ETGTTQKGLT
2010 2020 2030 2040 2050
QLELAEPVKI QLVSILDHLC DIQLRYRIES LVAFTEGFVG ELQSDQCKRY
2060 2070 2080 2090 2100
MEIKQTDMPP AEAAKKTKEF RCPPKEQMFR LLMCKVKEER DPELMEEDAD
2110 2120 2130 2140 2150
VDQCPMAEGL QQQLRDFCEL LVGKIGNVKE GDSDDQLALI ESEEGSWVDS
2160 2170 2180 2190 2200
FARIVVKVPP PVLEEGMEMQ KKGTQNFREI IVTMLREWAQ ADFIESKSLI
2210 2220 2230 2240 2250
RNMFRLLLRQ YSGIREIRDA MSQTYVFHER NEKDVTDFLV YLIQIRELLT
2260 2270 2280 2290 2300
VQFEHTEEAI LKRGLWKLMN NRIFFQHPDL MRLLSVHENV MSIMMNILTA
2310 2320 2330 2340 2350
QQGTVEHEGD ELKEKAPIKD ASEMVVACSR FLCYFCRTSR QNQKAMFEHL
2360 2370 2380 2390 2400
SFLLDNATML LARPSLRGSV PLDVAYSSFM DNNELALALK EEELDKVAVY
2410 2420 2430 2440 2450
LSRCGLQPNS ELITKGYPDI GWDPVEGERY IDFLRFCVWI NGENVEENAN
2460 2470 2480 2490 2500
LVIRLLIRRP ECLGVALKGE GQGLFSAFKE AIALSEDIRL LENDSHPSLL
2510 2520 2530 2540 2550
SSGLLGENPT YPSKDAEGED YIDLGAATLD FYSSLVDLLA KCAPDPMAIQ
2560 2570 2580 2590 2600
AGKGDSLRAR AILRSLISLD DLGQILALRF TIPNLAAPSI EDTGPLPGLL
2610 2620 2630 2640 2650
PNHKGSVLLF LDRVYGIDQQ DMLFHVLEQS FLPDLRAATM MDSPRALESD
2660 2670 2680 2690 2700
TALALNRYLC NSVLPLLTNH SHFFADAEHH SALLDATLHT VYRMNRLKSL
2710 2720 2730 2740 2750
TKNQRDAVSD FLVAITRELP PAMMIKLLKK VITDILTMND MNVLVPLRLI
2760 2770 2780 2790 2800
TLHYERCGKY YGSGNHYGVA SEQEKRLSML LFDAIFDTLG SRPYDPELFG
2810 2820 2830 2840 2850
KALPCMTAIG SAISPDYTLT SGLEDVRNKR REEEGAWIPR TVDVSRCEIN
2860 2870 2880 2890 2900
RDLEKMTELF AEHFHDSWAS RKLEKGWVHG DLYSRANFTH PRLKPFALLK
2910 2920 2930 2940 2950
DFEKSFYKER CSECLKALMA WNYSFEMMDR DANDRASAAR TLSGTSISNF
2960 2970 2980 2990 3000
APKPIDLSSM TLEKDMVNAA EKMAEHSHLI WAKKVMNDLN TKGGFMPIPL
3010 3020 3030 3040 3050
VPWDLLTDFE RRKDRFRASE ILKFLQYHGY HVNCPKDEQS QNDRLKSEGE
3060 3070 3080 3090 3100
RTSVEKRFAY NLLEKLITYL EQASLKMKSV KPSQELTRRN SFKKEGQDVK
3110 3120 3130 3140 3150
FFEKVVLPLM HAYFNAHKNY FLEGSSIVQT GTASNKEKEM VANLFCRLAA
3160 3170 3180 3190 3200
LLRIKNRAFG SVAKITVKCL QGLTQALDLR TLVKVNSDIV RTSLLTFFNN
3210 3220 3230 3240 3250
CADDLYASVN ELKDGGQYSL IRGQALKSWN SFEFANQMIV PVLTTMFAHL
3260 3270 3280 3290 3300
ARNHFGTDLL LDDIQAACYK ILDSLYMVTG LSSSISHRKS ISGESEKHRP
3310 3320 3330 3340 3350
GLGQCLAAFA SCFPVAFLEP EFNKSNKFSV LAKSQDQSVQ VQEMLQNLST
3360 3370 3380 3390 3400
HIPHLEKLLT DLETVANNNT MYSDVPNVYD VDLPLMCSYM AHWFSVGPDG
3410 3420 3430 3440 3450
KRDKEDQRAS VVQTTSVSCD HINRIFNALL KMIRNHVGIE NAPWLCRVNF
3460 3470 3480 3490 3500
FAVQIIQNVT SDPVREFVLP IAERLRRMSE KAYKEEEHMR THPDDADEGT
3510 3520 3530 3540 3550
VAEDNARLVR DTYAFFPILM KYTDLHRAQW LKTPTWETDG VYENVAVIFR
3560 3570 3580 3590 3600
IWSQSQHFKR EELNYVAQFE EDAAATGGGD MKTGKAAIAE RKKKRREGQD
3610 3620 3630 3640 3650
KMKEYFDRNG RPIIKKDKHA ASIVIACLKR LLPVGLNVFG GRELDIVQQS
3660 3670 3680 3690 3700
KEKFIQKETE EKIREFIKGL LEIPVKTDPT DKNAWQLSLY RKIGKSQMRG
3710 3720 3730 3740 3750
KDEMSQDAVI EKIFNMGQVS AILHTMTSRM EKEDIWKKVL TLQRKRMAIS
3760 3770 3780 3790 3800
LITASHLYKT ELHRGINFFL PAFSRLWMEE EDAGQDQLIA DICSGVEEEE
3810 3820 3830 3840 3850
GPRIEIIMEE GVPIVASSED TKEKETNPDP LKQLIRCFQR AATSEETAAS
3860 3870 3880 3890 3900
AIHEDSLYIR FADVMAKSIH IEEEDGEDGE EGEIDQAAKE EQSQALRGEQ
3910 3920 3930 3940 3950
AVLASRGAAI MCLMYLSASG GEPNEMVAQT LQLGIHLLSG GNVEIQKMLI
3960 3970 3980 3990 4000
EYLQLKKDVR FFTSMAGLMN KCSVLNLEMF ERQIKAEGLG MGAELASGDN
4010 4020 4030 4040 4050
QNLNDADFTC SLFRFLQLTC EGHNLEFQNY LRTQPGHTTS VNLINCTVDY
4060 4070 4080 4090 4100
LLRLQESVMD FYWHYSSKEV IDEGGKEYFL RAIQVCSQVF NTLTESIQGP
4110 4120 4130 4140 4150
CVGNQMTLAN SRLWDAINGF FFLFAHMMEK LYKNSTQLEL LREFLNLQKD
4160 4170 4180 4190 4200
MIVLMLSMLE GNVLNGSIGK QMVDALVESQ PSVEKILKFS DMFLKLKDLT
4210 4220 4230 4240 4250
TSQAFQDFDT NQDGWISPKE FQRAMESQKM YTVEDITYLM MCTDVNNDGK
4260 4270 4280 4290 4300
VDYMEFTERF HNPARDIGFN LAVLLVNLKE HITNDPRLEK IIEKAQTLLE
4310 4320 4330 4340 4350
YFDPFLGRIE IMGSSKRVEK IYFEIQESWL EQWGKQQIRD SKNSFLFNVL
4360 4370 4380 4390 4400
QDDGGDQGKL EAFINFCEDT IFEMQHAAAI SSGDSDTKME RAIKQRDYFL
4410 4420 4430 4440 4450
QQTSADHISE TFKSGYNYGI SAASALSPQN ISTTMRNVSS SVRQMSWTQL
4460 4470 4480 4490 4500
LYAVIILFIR AGLAIGWAGY LLLMTIFRFG YFLTTSSEEE EAARQEKEQA
4510 4520 4530 4540 4550
KMNNEHPSFN PPIIQEFHHS HVGVTAFGVG MNADHLNVNS LPDFVPPERP
4560 4570 4580 4590 4600
ETPETVLEEE KPLNQETSPP TSPTSPASKA PSIYESIGAP QMVQLQSEAD
4610 4620 4630 4640 4650
FQQGQYEPKI AESNSTKSRG SILNMLARNF KTIEKITLYL AFFINVILLF
4660 4670 4680 4690 4700
HRVDISHAEN AEAASEGDDD EDALESIFIT GMQFPYVEYE ITGWMLAQIL
4710 4720 4730 4740 4750
YWISVLHLST SFALLVSFYQ LKIPLITFKR EKEIARKLMF DGCWITEEDS
4760 4770 4780 4790 4800
EELGIVDTFM WYLDRIVVSA KSFPMMYWDK FVRRKTRSKF KDQVDEETLT
4810 4820 4830 4840 4850
SILGEEKMST DSSYDYRYSC WLWIGVILTN GQFLYRVGYL LCSACGVFLS
4860 4870 4880 4890 4900
PFFYAFHLID VVLSFPMLKA ILQSVTHNLQ QLILTIMMTL VVVYLYTVIA
4910 4920 4930 4940 4950
FNFFRKFYVQ EGEEGEEPDR KCHNMLTCFI YHFYAGVRAG GGIGDELESP
4960 4970 4980 4990 5000
YGDDLEYPRM FYDISFFFFV IIILLAIMQG LIIDAFGELR DQQESATEKL
5010 5020 5030 5040 5050
ESSCFICDIG KETFDRMPRG FEIHTTKEHN FANYLFFLQH LVNKDETEYT
5060 5070 5080
GQETYVREKY DNRDWDFFPV GECFVKQYED QLLQS
Length:5,085
Mass (Da):578,070
Last modified:December 20, 2017 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB593751433D70F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I2HAA6I2HAA6_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,187Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q94279Q94279_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,201Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I2HAA7I2HAA7_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,071Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C3E8A0A2C9C3E8_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,202Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C3P6A0A2C9C3P6_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,199Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C2X2A0A2C9C2X2_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C325A0A2C9C325_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C354A0A2C9C354_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,086Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C370A0A2C9C370_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,070Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C384A0A2C9C384_CAEEL
Uncharacterized protein
unc-68 CELE_K11C4.5, K11C4.5
5,200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD72906.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K11C4.5b.1; K11C4.5b.1; WBGene00006801

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD72906.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiB7WN66
PeptideAtlasiB7WN66

Genome annotation databases

EnsemblMetazoaiK11C4.5b.1; K11C4.5b.1; WBGene00006801

Organism-specific databases

WormBaseiK11C4.5b ; CE52133 ; WBGene00006801 ; unc-68

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000168850
HOGENOMiHOG000231428
OrthoDBi5161at2759

Gene expression databases

BgeeiWBGene00006801 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiB7WN66 baseline and differential

Family and domain databases

CDDicd00051 EFh, 1 hit
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7WN66_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7WN66
Secondary accession number(s): G4SNF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: December 20, 2017
Last modified: September 18, 2019
This is version 92 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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