UniProtKB - B7UPE2 (RPOB_ECO27)
Protein
DNA-directed RNA polymerase subunit beta
Gene
rpoB
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation
Catalytic activityi
- EC:2.7.7.6UniRule annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-UniRule
- ribonucleoside binding Source: InterPro
GO - Biological processi
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Transcription |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)Short name: RNAP subunit betaUniRule annotation Alternative name(s): RNA polymerase subunit betaUniRule annotation Transcriptase subunit betaUniRule annotation |
Gene namesi | Name:rpoBUniRule annotation Ordered Locus Names:E2348C_4294 |
Organismi | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
Taxonomic identifieri | 574521 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000165805 | 1 – 1342 | DNA-directed RNA polymerase subunit betaAdd BLAST | 1342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1022 | N6-acetyllysineUniRule annotation | 1 | |
Modified residuei | 1200 | N6-acetyllysineUniRule annotation | 1 |
Keywords - PTMi
AcetylationInteractioni
Subunit structurei
The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the RNA polymerase beta chain family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_000524_4_3_6 |
OMAi | FMTWEGY |
Family and domain databases
CDDi | cd00653, RNA_pol_B_RPB2, 1 hit |
Gene3Di | 2.40.270.10, 2 hits 2.40.50.150, 1 hit 3.90.1110.10, 2 hits |
HAMAPi | MF_01321, RNApol_bact_RpoB, 1 hit |
InterProi | View protein in InterPro IPR019462, DNA-dir_RNA_pol_bsu_external_1 IPR015712, DNA-dir_RNA_pol_su2 IPR007120, DNA-dir_RNAP_su2_dom IPR037033, DNA-dir_RNAP_su2_hyb_sf IPR010243, RNA_pol_bsu_bac IPR007121, RNA_pol_bsu_CS IPR007644, RNA_pol_bsu_protrusion IPR007642, RNA_pol_Rpb2_2 IPR037034, RNA_pol_Rpb2_2_sf IPR007645, RNA_pol_Rpb2_3 IPR007641, RNA_pol_Rpb2_7 IPR014724, RNA_pol_RPB2_OB-fold |
PANTHERi | PTHR20856, PTHR20856, 1 hit |
Pfami | View protein in Pfam PF04563, RNA_pol_Rpb2_1, 1 hit PF04561, RNA_pol_Rpb2_2, 2 hits PF04565, RNA_pol_Rpb2_3, 1 hit PF10385, RNA_pol_Rpb2_45, 1 hit PF00562, RNA_pol_Rpb2_6, 1 hit PF04560, RNA_pol_Rpb2_7, 1 hit |
TIGRFAMsi | TIGR02013, rpoB, 1 hit |
PROSITEi | View protein in PROSITE PS01166, RNA_POL_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
B7UPE2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVYSYTEKKR IRKDFGKRPQ VLDVPYLLSI QLDSFQKFIE QDPEGQYGLE
60 70 80 90 100
AAFRSVFPIQ SYSGNSELQY VSYRLGEPVF DVQECQIRGV TYSAPLRVKL
110 120 130 140 150
RLVIYEREAP EGTVKDIKEQ EVYMGEIPLM TDNGTFVING TERVIVSQLH
160 170 180 190 200
RSPGVFFDSD KGKTHSSGKV LYNARIIPYR GSWLDFEFDP KDNLFVRIDR
210 220 230 240 250
RRKLPATIIL RALNYTTEQI LDLFFEKVIF EIRDNKLQME LVPERLRGET
260 270 280 290 300
ASFDIEANGK VYVEKGRRIT ARHIRQLEKD DVKLIEVPVE YIAGKVVAKD
310 320 330 340 350
YIDESTGELI CAANMELSLD LLAKLSQSGH KRIETLFTND LDHGPYISET
360 370 380 390 400
LRVDPTNDRL SALVEIYRMM RPGEPPTREA AESLFENLFF SEDRYDLSAV
410 420 430 440 450
GRMKFNRSLL REEIEGSGIL SKDDIIDVMK KLIDIRNGKG EVDDIDHLGN
460 470 480 490 500
RRIRSVGEMA ENQFRVGLVR VERAVKERLS LGDLDTLMPQ DMINAKPISA
510 520 530 540 550
AVKEFFGSSQ LSQFMDQNNP LSEITHKRRI SALGPGGLTR ERAGFEVRDV
560 570 580 590 600
HPTHYGRVCP IETPEGPNIG LINSLSVYAQ TNEYGFLETP YRKVTDGVVT
610 620 630 640 650
DEIHYLSAIE EGNYVIAQAN SNLDEEGHFV EDLVTCRSKG ESSLFSRDQV
660 670 680 690 700
DYMDVSTQQV VSVGASLIPF LEHDDANRAL MGANMQRQAV PTLRADKPLV
710 720 730 740 750
GTGMERAVAV DSGVTAVAKR GGVVQYVDAS RIVIKVNEDE MYPGEAGIDI
760 770 780 790 800
YNLTKYTRSN QNTCINQMPC VSLGEPVERG DVLADGPSTD LGELALGQNM
810 820 830 840 850
RVAFMPWNGY NFEDSILVSE RVVQEDRFTT IHIQELACVS RDTKLGPEEI
860 870 880 890 900
TADIPNVGEA ALSKLDESGI VYIGAEVTGG DILVGKVTPK GETQLTPEEK
910 920 930 940 950
LLRAIFGEKA SDVKDSSLRV PNGVSGTVID VQVFTRDGVE KDKRALEIEE
960 970 980 990 1000
MQLKQAKKDL SEELQILEAG LFSRIRAVLV AGGVEAEKLD KLPRDRWLEL
1010 1020 1030 1040 1050
GLTDEEKQNQ LEQLAEQYDE LKHEFEKKLE AKRRKITQGD DLAPGVLKIV
1060 1070 1080 1090 1100
KVYLAVKRRI QPGDKMAGRH GNKGVISKIN PIEDMPYDEN GTPVDIVLNP
1110 1120 1130 1140 1150
LGVPSRMNIG QILETHLGMA AKGIGDKINA MLKQQQEVAK LREFIQRAYD
1160 1170 1180 1190 1200
LGADVRQKVD LSTFSDEEVM RLAENLRKGM PIATPVFDGA KEAEIKELLK
1210 1220 1230 1240 1250
LGDLPTSGQI RLYDGRTGEQ FERPVTVGYM YMLKLNHLVD DKMHARSTGS
1260 1270 1280 1290 1300
YSLVTQQPLG GKAQFGGQRF GEMEVWALEA YGAAYTLQEM LTVKSDDVNG
1310 1320 1330 1340
RTKMYKNIVD GNHQMEPGMP ESFNVLLKEI RSLGINIELE DE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11842.1 |
RefSeqi | WP_000263098.1, NC_011601.1 |
Genome annotation databases
EnsemblBacteriai | CAS11842; CAS11842; E2348C_4294 |
GeneIDi | 52078739 |
KEGGi | ecg:E2348C_4294 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11842.1 |
RefSeqi | WP_000263098.1, NC_011601.1 |
3D structure databases
SMRi | B7UPE2 |
ModBasei | Search... |
Chemistry databases
ChEMBLi | CHEMBL4296294 |
Genome annotation databases
EnsemblBacteriai | CAS11842; CAS11842; E2348C_4294 |
GeneIDi | 52078739 |
KEGGi | ecg:E2348C_4294 |
Phylogenomic databases
HOGENOMi | CLU_000524_4_3_6 |
OMAi | FMTWEGY |
Family and domain databases
CDDi | cd00653, RNA_pol_B_RPB2, 1 hit |
Gene3Di | 2.40.270.10, 2 hits 2.40.50.150, 1 hit 3.90.1110.10, 2 hits |
HAMAPi | MF_01321, RNApol_bact_RpoB, 1 hit |
InterProi | View protein in InterPro IPR019462, DNA-dir_RNA_pol_bsu_external_1 IPR015712, DNA-dir_RNA_pol_su2 IPR007120, DNA-dir_RNAP_su2_dom IPR037033, DNA-dir_RNAP_su2_hyb_sf IPR010243, RNA_pol_bsu_bac IPR007121, RNA_pol_bsu_CS IPR007644, RNA_pol_bsu_protrusion IPR007642, RNA_pol_Rpb2_2 IPR037034, RNA_pol_Rpb2_2_sf IPR007645, RNA_pol_Rpb2_3 IPR007641, RNA_pol_Rpb2_7 IPR014724, RNA_pol_RPB2_OB-fold |
PANTHERi | PTHR20856, PTHR20856, 1 hit |
Pfami | View protein in Pfam PF04563, RNA_pol_Rpb2_1, 1 hit PF04561, RNA_pol_Rpb2_2, 2 hits PF04565, RNA_pol_Rpb2_3, 1 hit PF10385, RNA_pol_Rpb2_45, 1 hit PF00562, RNA_pol_Rpb2_6, 1 hit PF04560, RNA_pol_Rpb2_7, 1 hit |
TIGRFAMsi | TIGR02013, rpoB, 1 hit |
PROSITEi | View protein in PROSITE PS01166, RNA_POL_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPOB_ECO27 | |
Accessioni | B7UPE2Primary (citable) accession number: B7UPE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |