UniProtKB - B7UNP9 (RRAA_ECO27)
Protein
Regulator of ribonuclease activity A
Gene
rraA
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Functioni
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.UniRule annotation
GO - Molecular functioni
- endoribonuclease inhibitor activity Source: UniProtKB-UniRule
- enzyme binding Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of ribonuclease activity AUniRule annotation |
Gene namesi | Name:rraAUniRule annotation Ordered Locus Names:E2348C_4233 |
Organismi | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
Taxonomic identifieri | 574521 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000135490 | 1 – 161 | Regulator of ribonuclease activity AAdd BLAST | 161 |
Interactioni
Subunit structurei
Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.
UniRule annotationGO - Molecular functioni
- enzyme binding Source: UniProtKB-UniRule
Family & Domainsi
Sequence similaritiesi
Belongs to the RraA family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_072626_4_0_6 |
OMAi | RSCDTQF |
Family and domain databases
CDDi | cd16841, RraA_family, 1 hit |
HAMAPi | MF_00471, RraA, 1 hit |
InterProi | View protein in InterPro IPR010203, RraA IPR005493, RraA/RraA-like IPR036704, RraA/RraA-like_sf IPR014339, RraA_gpbac |
Pfami | View protein in Pfam PF03737, RraA-like, 1 hit |
SUPFAMi | SSF89562, SSF89562, 1 hit |
TIGRFAMsi | TIGR01935, NOT-MenG, 1 hit TIGR02998, RraA_entero, 1 hit |
i Sequence
Sequence statusi: Complete.
B7UNP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKYDTSELCD IYQEDVNVVE PLFSNFGGRA SFGGQIITVK CFEDNGLLYD
60 70 80 90 100
LLEQNGRGRV LVVDGGGSVR RALVDAELAR LAVQNEWEGL VIYGAVRQVD
110 120 130 140 150
DLEELDIGIQ AMAAIPVGAA GEGIGESDVR VNFGGVTFFS GDHLYADNTG
160
IILSEDPLDI E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11781.1 |
RefSeqi | WP_000872908.1, NC_011601.1 |
Genome annotation databases
EnsemblBacteriai | CAS11781; CAS11781; E2348C_4233 |
GeneIDi | 52078800 |
KEGGi | ecg:E2348C_4233 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11781.1 |
RefSeqi | WP_000872908.1, NC_011601.1 |
3D structure databases
SMRi | B7UNP9 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAS11781; CAS11781; E2348C_4233 |
GeneIDi | 52078800 |
KEGGi | ecg:E2348C_4233 |
Phylogenomic databases
HOGENOMi | CLU_072626_4_0_6 |
OMAi | RSCDTQF |
Family and domain databases
CDDi | cd16841, RraA_family, 1 hit |
HAMAPi | MF_00471, RraA, 1 hit |
InterProi | View protein in InterPro IPR010203, RraA IPR005493, RraA/RraA-like IPR036704, RraA/RraA-like_sf IPR014339, RraA_gpbac |
Pfami | View protein in Pfam PF03737, RraA-like, 1 hit |
SUPFAMi | SSF89562, SSF89562, 1 hit |
TIGRFAMsi | TIGR01935, NOT-MenG, 1 hit TIGR02998, RraA_entero, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RRAA_ECO27 | |
Accessioni | B7UNP9Primary (citable) accession number: B7UNP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |