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Protein

ATP-dependent RNA helicase RhlB

Gene

rhlB

Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 60ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase RhlBUniRule annotation (EC:3.6.4.13UniRule annotation)
Gene namesi
Name:rhlBUniRule annotation
Ordered Locus Names:E2348C_4080
OrganismiEscherichia coli O127:H6 (strain E2348/69 / EPEC)
Taxonomic identifieri574521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008205 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001475801 – 421ATP-dependent RNA helicase RhlBAdd BLAST421

Interactioni

Subunit structurei

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7UMN5
SMRiB7UMN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 219Helicase ATP-bindingUniRule annotationAdd BLAST180
Domaini245 – 390Helicase C-terminalUniRule annotationAdd BLAST146

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 37Q motifAdd BLAST29
Motifi165 – 168DEAD box4

Sequence similaritiesi

Belongs to the DEAD box helicase family. RhlB subfamily.UniRule annotation

Phylogenomic databases

KOiK03732
OMAiRNPIRIL

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00661 DEAD_helicase_RhlB, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR023554 RNA_helicase_ATP-dep_RhlB
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

B7UMN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTHLTEQK FSDFALHPKV VEALEKKGFH NCTPIQALAL PLTLAGRDVA
60 70 80 90 100
GQAQTGTGKT MAFLTSTFHY LLSHPAIADR KVNQPRALIM APTRELAVQI
110 120 130 140 150
HADAEPLAEA TGLKLGLAYG GDGYDKQLKV LESGVDILIG TTGRLIDYAK
160 170 180 190 200
QNHINLGAIQ VVVLDEADRM YDLGFIKDIR WLFRRMPPAN QRLNMLFSAT
210 220 230 240 250
LSYRVRELAF EQMNNAEYIE VEPEQKTGHR IKEELFYPSN EEKMRLLQTL
260 270 280 290 300
IEEEWPDRAI IFANTKHRCE EIWGHLAADG HRVGLLTGDV AQKKRLRILD
310 320 330 340 350
EFTRGDLDIL VATDVAARGL HIPAVTHVFN YDLPDDCEDY VHRIGRTGRA
360 370 380 390 400
GASGHSISLA CEEYALNLPA IETYIGHSIP VSKYNPDALM TDLPKPLRLT
410 420
RPRTGNGPRR TGAPRNRRRS G
Length:421
Mass (Da):47,126
Last modified:February 10, 2009 - v1
Checksum:i48E1ADD025CBFA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM180568 Genomic DNA Translation: CAS11628.1
RefSeqiWP_000047499.1, NC_011601.1

Genome annotation databases

EnsemblBacteriaiCAS11628; CAS11628; E2348C_4080
KEGGiecg:E2348C_4080

Similar proteinsi

Entry informationi

Entry nameiRHLB_ECO27
AccessioniPrimary (citable) accession number: B7UMN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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