UniProtKB - B7UMG9 (DNAA_ECO27)
Protein
Chromosomal replication initiator protein DnaA
Gene
dnaA
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Functioni
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 172 – 179 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA replication origin binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication initiation Source: UniProtKB-UniRule
- regulation of DNA replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosomal replication initiator protein DnaAUniRule annotation |
Gene namesi | Name:dnaAUniRule annotation Ordered Locus Names:E2348C_4013 |
Organismi | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
Taxonomic identifieri | 574521 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000189796 | 1 – 467 | Chromosomal replication initiator protein DnaAAdd BLAST | 467 |
Family & Domainsi
Sequence similaritiesi
Belongs to the DnaA family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_026910_0_1_6 |
OMAi | REFNPLF |
Family and domain databases
CDDi | cd06571, Bac_DnaA_C, 1 hit |
Gene3Di | 1.10.1750.10, 1 hit 3.30.300.180, 1 hit |
HAMAPi | MF_00377, DnaA_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR001957, Chromosome_initiator_DnaA IPR020591, Chromosome_initiator_DnaA-like IPR018312, Chromosome_initiator_DnaA_CS IPR013317, DnaA IPR013159, DnaA_C IPR024633, DnaA_N_dom IPR038454, DnaA_N_sf IPR027417, P-loop_NTPase IPR010921, Trp_repressor/repl_initiator |
PANTHERi | PTHR30050:SF2, PTHR30050:SF2, 1 hit |
Pfami | View protein in Pfam PF00308, Bac_DnaA, 1 hit PF08299, Bac_DnaA_C, 1 hit PF11638, DnaA_N, 1 hit |
PRINTSi | PR00051, DNAA |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00760, Bac_DnaA_C, 1 hit |
SUPFAMi | SSF48295, SSF48295, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00362, DnaA, 1 hit |
PROSITEi | View protein in PROSITE PS01008, DNAA, 1 hit |
i Sequence
Sequence statusi: Complete.
B7UMG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW
60 70 80 90 100
VRDKYLNNIN GLLTSFCGAD APQLRFEVGT KPVTQTPQAA VTSNVAAPAQ
110 120 130 140 150
VAQTQPQRAA PSTRSGWDNV PAPAEPTYRS NVNVKHTFDN FVEGKSNQLA
160 170 180 190 200
RAAARQVADN PGGAYNPLFL YGGTGLGKTH LLHAVGNGIM ARKPNAKVVY
210 220 230 240 250
MHSERFVQDM VKALQNNAIE EFKRYYRSVD ALLIDDIQFF ANKERSQEEF
260 270 280 290 300
FHTFNALLEG NQQIILTSDR YPKEINGVED RLKSRFGWGL TVAIEPPELE
310 320 330 340 350
TRVAILMKKA DENDIRLPGE VAFFIAKRLR SNVRELEGAL NRVIANANFT
360 370 380 390 400
GRAITIDFVR EALRDLLALQ EKLVTIDNIQ KTVAEYYKIK VADLLSKRRS
410 420 430 440 450
RSVARPRQMA MALAKELTNH SLPEIGDAFG GRDHTTVLHA CRKIEQLREE
460
SHDIKEDFSN LIRTLSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11561.1 |
RefSeqi | WP_000059111.1, NC_011601.1 |
Genome annotation databases
EnsemblBacteriai | CAS11561; CAS11561; E2348C_4013 |
GeneIDi | 49582322 |
KEGGi | ecg:E2348C_4013 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11561.1 |
RefSeqi | WP_000059111.1, NC_011601.1 |
3D structure databases
SMRi | B7UMG9 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAS11561; CAS11561; E2348C_4013 |
GeneIDi | 49582322 |
KEGGi | ecg:E2348C_4013 |
Phylogenomic databases
HOGENOMi | CLU_026910_0_1_6 |
OMAi | REFNPLF |
Family and domain databases
CDDi | cd06571, Bac_DnaA_C, 1 hit |
Gene3Di | 1.10.1750.10, 1 hit 3.30.300.180, 1 hit |
HAMAPi | MF_00377, DnaA_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR001957, Chromosome_initiator_DnaA IPR020591, Chromosome_initiator_DnaA-like IPR018312, Chromosome_initiator_DnaA_CS IPR013317, DnaA IPR013159, DnaA_C IPR024633, DnaA_N_dom IPR038454, DnaA_N_sf IPR027417, P-loop_NTPase IPR010921, Trp_repressor/repl_initiator |
PANTHERi | PTHR30050:SF2, PTHR30050:SF2, 1 hit |
Pfami | View protein in Pfam PF00308, Bac_DnaA, 1 hit PF08299, Bac_DnaA_C, 1 hit PF11638, DnaA_N, 1 hit |
PRINTSi | PR00051, DNAA |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00760, Bac_DnaA_C, 1 hit |
SUPFAMi | SSF48295, SSF48295, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00362, DnaA, 1 hit |
PROSITEi | View protein in PROSITE PS01008, DNAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNAA_ECO27 | |
Accessioni | B7UMG9Primary (citable) accession number: B7UMG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 2, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |