UniProtKB - B7UKC3 (MALT_ECO27)
Protein
HTH-type transcriptional regulator MalT
Gene
malT
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Functioni
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.UniRule annotation
Activity regulationi
Activated by ATP and maltotriose, which are both required for DNA binding.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 39 – 46 | ATPUniRule annotation | 8 | |
DNA bindingi | 853 – 872 | H-T-H motifUniRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: UniProtKB-UniRule
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-KW
- positive regulation of carbohydrate metabolic process Source: UniProtKB-UniRule
- positive regulation of transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Carbohydrate metabolism, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator MalTUniRule annotationAlternative name(s): ATP-dependent transcriptional activator MalTUniRule annotation |
Gene namesi | Name:malTUniRule annotation Ordered Locus Names:E2348C_3663 |
Organismi | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
Taxonomic identifieri | 574521 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000165051 | 1 – 901 | HTH-type transcriptional regulator MalTAdd BLAST | 901 |
Interactioni
Subunit structurei
Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 829 – 894 | HTH luxR-typeUniRule annotationAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the MalT family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_006325_3_0_6 |
OMAi | SDWVSNA |
Family and domain databases
CDDi | cd06170, LuxR_C_like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.25.40.10, 1 hit |
HAMAPi | MF_01247, HTH_type_MalT, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR016032, Sig_transdc_resp-reg_C-effctor IPR011990, TPR-like_helical_dom_sf IPR041617, TPR_MalT IPR023768, Tscrpt_reg_HTH_MalT IPR000792, Tscrpt_reg_LuxR_C IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF00196, GerE, 1 hit PF17874, TPR_MalT, 1 hit |
PRINTSi | PR00038, HTHLUXR |
SMARTi | View protein in SMART SM00421, HTH_LUXR, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF48452, SSF48452, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00622, HTH_LUXR_1, 1 hit PS50043, HTH_LUXR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B7UKC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALITSP AGYGKTTLIS
60 70 80 90 100
QWAAGKNDIG WYSLDEGDNQ QERFASYLIA AMQQATNGHC AICETMAQKR
110 120 130 140 150
QYASLTSLFA QLFIELAEWH SPLYLVIDDY HLITNPVIHE SMRFFIRHQP
160 170 180 190 200
ENLTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFTHQE AKQFFDCRLS
210 220 230 240 250
SPIEAAESSR ICDDVSGWAT ALQLIALSAR QNTHSAHKSA RRLAGINASH
260 270 280 290 300
LSDYLVDEVL DNVDLATRHF LLKSAILRSM NDALINRVTG EENGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDTGEWFCY HPLFGNFLRQ RCQWELAAEL PEIHRAAAES
360 370 380 390 400
WMAQGFPSEA IHHALAAGDA LMLRDILLNH AWSLFNHSEL SLLEESLKAL
410 420 430 440 450
PWDSLLENPQ LVLLQAWLMQ SQHRYGEVNT LLARAEHEIK DIREGTMHAE
460 470 480 490 500
FNALRAQVAI NDGNPDEAER LAKLALEELP PGWFYSRIVA TSVLGEVLHC
510 520 530 540 550
KGELTRSLAL MQQTEQMARQ HDVWHYALWS LIQQSEILFA QGFLQTAWET
560 570 580 590 600
QEKAFQLINE QHLEQLPMHE FLVRIRAQLL WAWARLDEAE ASARSGIEVL
610 620 630 640 650
SSYQPQQQLQ CLAMLIQCSL ARGDLDNARS QLNRLENLLG NGKYHSDWIS
660 670 680 690 700
NANKVRVIYW QMTGDKAAAA NWLRHTAKPE FANNHFLQGQ WRNIARAQIL
710 720 730 740 750
LGEFEPAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ AGRKSDAQRV
760 770 780 790 800
LLDALKLANR TGFISHFVIE GEAMAQQLRQ LIQLNTLPEL EQHRAQRILR
810 820 830 840 850
EINQHHRHKF AHFDENFVER LLNHPEVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL EVAATTIKTH IRNLYQKLGV AHRQAAVQHA QKLLKMMGYG
V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11211.1 |
RefSeqi | WP_000906936.1, NC_011601.1 |
Genome annotation databases
EnsemblBacteriai | CAS11211; CAS11211; E2348C_3663 |
KEGGi | ecg:E2348C_3663 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS11211.1 |
RefSeqi | WP_000906936.1, NC_011601.1 |
3D structure databases
SMRi | B7UKC3 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAS11211; CAS11211; E2348C_3663 |
KEGGi | ecg:E2348C_3663 |
Phylogenomic databases
HOGENOMi | CLU_006325_3_0_6 |
OMAi | SDWVSNA |
Family and domain databases
CDDi | cd06170, LuxR_C_like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.25.40.10, 1 hit |
HAMAPi | MF_01247, HTH_type_MalT, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR016032, Sig_transdc_resp-reg_C-effctor IPR011990, TPR-like_helical_dom_sf IPR041617, TPR_MalT IPR023768, Tscrpt_reg_HTH_MalT IPR000792, Tscrpt_reg_LuxR_C IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF00196, GerE, 1 hit PF17874, TPR_MalT, 1 hit |
PRINTSi | PR00038, HTHLUXR |
SMARTi | View protein in SMART SM00421, HTH_LUXR, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF48452, SSF48452, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00622, HTH_LUXR_1, 1 hit PS50043, HTH_LUXR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MALT_ECO27 | |
Accessioni | B7UKC3Primary (citable) accession number: B7UKC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |