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UniProtKB - B7UI83 (CAIC_ECO27)
Protein
Crotonobetaine/carnitine--CoA ligase
Gene
caiC
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Functioni
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
UniRule annotationCatalytic activityi
- 4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + γ-butyrobetainyl-CoAUniRule annotationEC:6.2.1.48UniRule annotation
- EC:6.2.1.48UniRule annotation
- EC:6.2.1.48UniRule annotation
: carnitine metabolism Pathwayi
This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.
GO - Molecular functioni
- acid-thiol ligase activity Source: InterPro
- carnitine-CoA ligase activity Source: InterPro
- crotonobetaine-CoA ligase activity Source: InterPro
GO - Biological processi
- carnitine metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Ligase |
Enzyme and pathway databases
UniPathwayi | UPA00117 |
Names & Taxonomyi
Protein namesi | Recommended name: Crotonobetaine/carnitine--CoA ligaseUniRule annotation (EC:6.2.1.48UniRule annotation) |
Gene namesi | Name:caiCUniRule annotation Ordered Locus Names:E2348C_0038 |
Organismi | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
Taxonomic identifieri | 574521 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000185129 | 1 – 517 | Crotonobetaine/carnitine--CoA ligaseAdd BLAST | 517 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_000022_59_0_6 |
OMAi | WLMQRAF |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_01524, CaiC, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023456, CaiC |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
B7UI83-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIIGGQHLR QMWDDLADVY GHKTALICES SSGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE
110 120 130 140 150
STWILQNSQA CLLVTSAQFY PMYQQIQQED ATQLRHICLT DVSLPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSTG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATITECIP MMIRTLMVQP LSANDQQHRL REVMFYLNLS
310 320 330 340 350
EQEKDAFCER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGQAGFCYE
360 370 380 390 400
AEIRDDHNRP LPAGEIGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EGFFYFVDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FCFCEQNMAK FKVLSYLEIR
510
KDLPRNCSGK IIRKNLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS07586.1 |
RefSeqi | WP_012578833.1, NC_011601.1 |
Genome annotation databases
EnsemblBacteriai | CAS07586; CAS07586; E2348C_0038 |
KEGGi | ecg:E2348C_0038 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS07586.1 |
RefSeqi | WP_012578833.1, NC_011601.1 |
3D structure databases
AlphaFoldDBi | B7UI83 |
SMRi | B7UI83 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAS07586; CAS07586; E2348C_0038 |
KEGGi | ecg:E2348C_0038 |
Phylogenomic databases
HOGENOMi | CLU_000022_59_0_6 |
OMAi | WLMQRAF |
Enzyme and pathway databases
UniPathwayi | UPA00117 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_01524, CaiC, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023456, CaiC |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAIC_ECO27 | |
Accessioni | B7UI83Primary (citable) accession number: B7UI83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families