UniProtKB - B7UHP7 (RPPH_ECO27)
Protein
RNA pyrophosphohydrolase
Gene
rppH
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Functioni
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation
Cofactori
a divalent metal cationUniRule annotation
GO - Molecular functioni
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Names & Taxonomyi
Protein namesi | Recommended name: RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)Alternative name(s): (Di)nucleoside polyphosphate hydrolaseUniRule annotation |
Gene namesi | Name:rppHUniRule annotation Synonyms:nudHUniRule annotation Ordered Locus Names:E2348C_3099 |
Organismi | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
Taxonomic identifieri | 574521 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000191843 | 1 – 176 | RNA pyrophosphohydrolaseAdd BLAST | 176 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 149 | Nudix hydrolaseUniRule annotationAdd BLAST | 144 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 38 – 59 | Nudix boxAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_087195_3_2_6 |
OMAi | PCVGIML |
Family and domain databases
CDDi | cd03671, Ap4A_hydrolase_plant_like, 1 hit |
HAMAPi | MF_00298, Nudix_RppH, 1 hit |
InterProi | View protein in InterPro IPR020476, Nudix_hydrolase IPR015797, NUDIX_hydrolase-like_dom_sf IPR020084, NUDIX_hydrolase_CS IPR000086, NUDIX_hydrolase_dom IPR022927, RppH |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
PRINTSi | PR00502, NUDIXFAMILY |
SUPFAMi | SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit PS00893, NUDIX_BOX, 1 hit |
i Sequence
Sequence statusi: Complete.
B7UHP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIDDDGYRPN VGIVICNRQG QVMWARRFGQ HSWQFPQGGI NPGESAEQAM
60 70 80 90 100
YRELFEEVGL SRKDVRILAS TRNWLRYKLP KRLVRWDTKP VCIGQKQKWF
110 120 130 140 150
LLQLVSGDAE INMQTSSTPE FDGWRWVSYW YPVRQVVSFK RDVYRRVMKE
160 170
FASVVMSLQE NTPKPQNASA YRRKRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS10647.1 |
RefSeqi | WP_000564489.1, NC_011601.1 |
Genome annotation databases
EnsemblBacteriai | CAS10647; CAS10647; E2348C_3099 |
GeneIDi | 49583277 |
KEGGi | ecg:E2348C_3099 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180568 Genomic DNA Translation: CAS10647.1 |
RefSeqi | WP_000564489.1, NC_011601.1 |
3D structure databases
SMRi | B7UHP7 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAS10647; CAS10647; E2348C_3099 |
GeneIDi | 49583277 |
KEGGi | ecg:E2348C_3099 |
Phylogenomic databases
HOGENOMi | CLU_087195_3_2_6 |
OMAi | PCVGIML |
Family and domain databases
CDDi | cd03671, Ap4A_hydrolase_plant_like, 1 hit |
HAMAPi | MF_00298, Nudix_RppH, 1 hit |
InterProi | View protein in InterPro IPR020476, Nudix_hydrolase IPR015797, NUDIX_hydrolase-like_dom_sf IPR020084, NUDIX_hydrolase_CS IPR000086, NUDIX_hydrolase_dom IPR022927, RppH |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
PRINTSi | PR00502, NUDIXFAMILY |
SUPFAMi | SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit PS00893, NUDIX_BOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPPH_ECO27 | |
Accessioni | B7UHP7Primary (citable) accession number: B7UHP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 2, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |