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Entry version 80 (16 Jan 2019)
Sequence version 3 (14 Oct 2015)
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Protein

Inward rectifier potassium channel 18

Gene

KCNJ18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • inward rectifier potassium channel activity Source: UniProtKB

GO - Biological processi

  • potassium ion import across plasma membrane Source: GO_Central
  • regulation of ion transmembrane transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inward rectifier potassium channel 18
Alternative name(s):
Inward rectifier K(+) channel Kir2.6
Potassium channel, inwardly rectifying subfamily J member 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNJ18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000260458.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:39080 KCNJ18

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613236 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_B7U540

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 84CytoplasmicSequence analysisAdd BLAST84
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 156ExtracellularSequence analysisAdd BLAST51
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 433CytoplasmicSequence analysisAdd BLAST256

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Thyrotoxic periodic paralysis 2 (TTPP2)4 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA sporadic muscular disorder characterized by episodic weakness and hypokalemia during a thyrotoxic state. It is clinically similar to hereditary hypokalemic periodic paralysis, except for the fact that hyperthyroidism is an absolute requirement for disease manifestation. The disease presents with recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Thyrotoxic periodic paralysis can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves disease.
See also OMIM:613239
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079833126 – 344Missing in TTPP2; abolishes potassium inward and outward currents density. 2 PublicationsAdd BLAST219
Natural variantiVAR_063286140T → M in TTPP2. 1 PublicationCorresponds to variant dbSNP:rs527236152EnsemblClinVar.1
Natural variantiVAR_079834168V → M in TTPP2; unknown pathological significance; decreases potassium inward and outward currents density; reduces cell surface abundance; reduces open propability; dominant negatif mutation. 1 PublicationCorresponds to variant dbSNP:rs527236154EnsemblClinVar.1
Natural variantiVAR_063287205R → H in TTPP2; hypermorphic; longer time required for half-maximal current degradation. 1 PublicationCorresponds to variant dbSNP:rs672601244EnsemblClinVar.1
Natural variantiVAR_063288354T → M in TTPP2; small decrease in current density. 1 PublicationCorresponds to variant dbSNP:rs527236158EnsemblClinVar.1
Natural variantiVAR_079838360K → T in TTPP2; abolishes potassium inward and outward currents density. 2 Publications1
Natural variantiVAR_063289366K → R in TTPP2; hypermorphic; longer time required for half-maximal current degradation. 1 PublicationCorresponds to variant dbSNP:rs527236159EnsemblClinVar.1
Natural variantiVAR_079839388E → K in TTPP2; reduces potassium inward and outward currents density. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi354T → E: Decreases the single-channel open probability (Po) without altering its conductance. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
100134444

MalaCards human disease database

More...
MalaCardsi
KCNJ18
MIMi613239 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000260458

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79102 Thyrotoxic periodic paralysis

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNJ18

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003951711 – 433Inward rectifier potassium channel 18Add BLAST433

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably phosphorylated by PKC; decreases single-channel open probability.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B7U540

ProteomicsDB human proteome resource

More...
ProteomicsDBi
6260

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B7U540

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B7U540

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by triiodothyronine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000260458 Expressed in 12 organ(s), highest expression level in skin of abdomen

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027021

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
B7U540, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B7U540

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B7U540

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3827 Eukaryota
ENOG410XQ62 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159955

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006178

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B7U540

KEGG Orthology (KO)

More...
KOi
K19468

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNMEDKP

Database of Orthologous Groups

More...
OrthoDBi
670633at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B7U540

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1400, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003272 K_chnl_inward-rec_Kir2.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR013673 K_chnl_inward-rec_Kir_N
IPR040445 Kir_TM

The PANTHER Classification System

More...
PANTHERi
PTHR11767 PTHR11767, 1 hit
PTHR11767:SF14 PTHR11767:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01007 IRK, 1 hit
PF08466 IRK_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01325 KIR22CHANNEL
PR01320 KIRCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7U540-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAASRANPY SIVSLEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN
60 70 80 90 100
GQCNIAFANM DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGV
110 120 130 140 150
IFWVIAVAHG DLEPAEGHGR TPCVMQVHGF MAAFLFSIET QTTIGYGLRC
160 170 180 190 200
VTEECLVAVF MVVAQSIVGC IIDSFMIGAI MAKMARPKKR AQTLLFSHNA
210 220 230 240 250
VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE GEYIPLDQID
260 270 280 290 300
IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE
310 320 330 340 350
GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE
360 370 380 390 400
VPSTPRCSAK DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS
410 420 430
RDGLSPQARH DFDRLQAGGG VLEQRPYRRG SEI
Length:433
Mass (Da):48,880
Last modified:October 14, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i284FC956E6139DD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6R → Q in ACJ64506 (PubMed:20074522).1
Sequence conflicti29N → K in ACJ64506 (PubMed:20074522).1
Sequence conflicti192Q → H in ACJ64506 (PubMed:20074522).1
Sequence conflicti192Q → H in AMQ11134 (PubMed:27008341).1
Sequence conflicti192Q → H in AMQ11135 (PubMed:27008341).1
Sequence conflicti281F → L in ACJ64506 (PubMed:20074522).1
Sequence conflicti338 – 342YKIDY → FKIDH in ACJ64506 (PubMed:20074522).5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07983039 – 40RR → QH2 Publications2
Natural variantiVAR_07983143R → C Found in a patient with sporadic periodic paralysis; unknown pathological significance; decreases potassium inward and outward currents density; reduces cell surface abundance; reduces conductance; dominant negatif mutation. 1 PublicationCorresponds to variant dbSNP:rs527236151EnsemblClinVar.1
Natural variantiVAR_07983256A → E1 PublicationCorresponds to variant dbSNP:rs1435508633Ensembl.1
Natural variantiVAR_079833126 – 344Missing in TTPP2; abolishes potassium inward and outward currents density. 2 PublicationsAdd BLAST219
Natural variantiVAR_063286140T → M in TTPP2. 1 PublicationCorresponds to variant dbSNP:rs527236152EnsemblClinVar.1
Natural variantiVAR_079834168V → M in TTPP2; unknown pathological significance; decreases potassium inward and outward currents density; reduces cell surface abundance; reduces open propability; dominant negatif mutation. 1 PublicationCorresponds to variant dbSNP:rs527236154EnsemblClinVar.1
Natural variantiVAR_079835169G → R Found in a patient with hypokalemic periodic paralysis without hyperthyroidism; reduces potassium inward and outward currents density. 1 PublicationCorresponds to variant dbSNP:rs1311839715Ensembl.1
Natural variantiVAR_079836200A → P Found in a patient with sporadic periodic paralysis; unknown pathological significance; abolishes potassium inward and outward currents density; reduces cell surface abundance. 1 PublicationCorresponds to variant dbSNP:rs527236155EnsemblClinVar.1
Natural variantiVAR_063287205R → H in TTPP2; hypermorphic; longer time required for half-maximal current degradation. 1 PublicationCorresponds to variant dbSNP:rs672601244EnsemblClinVar.1
Natural variantiVAR_079837249I → V2 PublicationsCorresponds to variant dbSNP:rs1182398045Ensembl.1
Natural variantiVAR_063288354T → M in TTPP2; small decrease in current density. 1 PublicationCorresponds to variant dbSNP:rs527236158EnsemblClinVar.1
Natural variantiVAR_079838360K → T in TTPP2; abolishes potassium inward and outward currents density. 2 Publications1
Natural variantiVAR_063289366K → R in TTPP2; hypermorphic; longer time required for half-maximal current degradation. 1 PublicationCorresponds to variant dbSNP:rs527236159EnsemblClinVar.1
Natural variantiVAR_079839388E → K in TTPP2; reduces potassium inward and outward currents density. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ434338 mRNA Translation: ACJ64506.2
KT828539 Genomic DNA Translation: AMQ11134.1
KT828540 Genomic DNA Translation: AMQ11135.1
AC233702 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74015.1

NCBI Reference Sequences

More...
RefSeqi
NP_001181887.2, NM_001194958.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.200629

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000567955; ENSP00000457807; ENSG00000260458

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100134444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100134444

UCSC genome browser

More...
UCSCi
uc032exz.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ434338 mRNA Translation: ACJ64506.2
KT828539 Genomic DNA Translation: AMQ11134.1
KT828540 Genomic DNA Translation: AMQ11135.1
AC233702 Genomic DNA No translation available.
CCDSiCCDS74015.1
RefSeqiNP_001181887.2, NM_001194958.2
UniGeneiHs.200629

3D structure databases

ProteinModelPortaliB7U540
SMRiB7U540
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7U540, 3 interactors

PTM databases

iPTMnetiB7U540
PhosphoSitePlusiB7U540

Polymorphism and mutation databases

BioMutaiKCNJ18

Proteomic databases

PRIDEiB7U540
ProteomicsDBi6260

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000567955; ENSP00000457807; ENSG00000260458
GeneIDi100134444
KEGGihsa:100134444
UCSCiuc032exz.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100134444
DisGeNETi100134444
EuPathDBiHostDB:ENSG00000260458.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNJ18
HGNCiHGNC:39080 KCNJ18
HPAiHPA027021
MalaCardsiKCNJ18
MIMi613236 gene
613239 phenotype
neXtProtiNX_B7U540
OpenTargetsiENSG00000260458
Orphaneti79102 Thyrotoxic periodic paralysis

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00940000159955
HOVERGENiHBG006178
InParanoidiB7U540
KOiK19468
OMAiNNMEDKP
OrthoDBi670633at2759
PhylomeDBiB7U540

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100134444

Protein Ontology

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PROi
PR:B7U540

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000260458 Expressed in 12 organ(s), highest expression level in skin of abdomen

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003272 K_chnl_inward-rec_Kir2.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR013673 K_chnl_inward-rec_Kir_N
IPR040445 Kir_TM
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF14 PTHR11767:SF14, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PF08466 IRK_N, 1 hit
PRINTSiPR01325 KIR22CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCJ18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7U540
Secondary accession number(s): A0A075B742, A0A142CKZ1, A0A142CKZ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 14, 2015
Last modified: January 16, 2019
This is version 80 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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