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Entry version 27 (18 Sep 2019)
Sequence version 1 (10 Feb 2009)
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Protein

Atromentin synthetase

Gene

atrA

Organism
Tapinella panuoides (Oyster rollrim mushroom) (Paxillus panuoides)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The L-tyrosine:2-oxoglutarate aminotransferase atrD and the atromentin synthetase atrA catalyze consecutive steps to turn over L-tyrosine into atromentin, which represents the generic precursor molecule for the entire terphenylquinone and pulvinic acid family of pigments, which are widely distributed secondary metabolites in homobasidiomycetes (PubMed:18805498). The first step is catalyzed by atrD which converts L-tyrosine in to 4-hydroxyphenylpyruvate (4-HPP) (PubMed:18805498). Adenylation of two 4-HPP monomers by the atrA adenylation (A) domain, ester bond formation between monomers and atrA, and symmetric C-C-bond formation between two monomers by atrA leads to atromentin (PubMed:18805498).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.37 µM for 4-hydroxyphenylpyruvic acid1 Publication
  2. KM=590 µM for 2-oxoglutarate1 Publication

    pH dependencei

    Optimum pH is 6.5.1 Publication

    Temperature dependencei

    Optimum temperature is 25 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

    This protein is involved in Secondary metabolite biosynthesis.1 Publication
    View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-18722

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Atromentin synthetase1 Publication (EC:2.3.1.-1 Publication)
    Alternative name(s):
    Atromentin biosynthesis protein ACurated
    Nonribosomal peptide synthase atrACurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:atrA1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTapinella panuoides (Oyster rollrim mushroom) (Paxillus panuoides)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri80604 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeBoletalesTapinellineaeTapinellaceaeTapinella

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

    Atromentin has been shown to induce caspase-3 and poly (ADP-ribose) polymerase (PARP) in human leukemia U937 cells (PubMed:19809251). It has also anticoagulant activity (PubMed:5862512). Moreover, atromentin has antimicrobial activity (PubMed:6541963). It acts especially as an inhibitor of FabK, the enoyl-acyl carrier protein (ACP) reductase of S.pneumoniae (PubMed:17323650).4 Publications

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004376781 – 957Atromentin synthetaseAdd BLAST957

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei633O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    B7STY1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini596 – 674CarrierPROSITE-ProRule annotationAdd BLAST79

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 464Adenylation (A) domainSequence analysisAdd BLAST406
    Regioni601 – 671Thiolation and peptide carrier (T) domainSequence analysisAdd BLAST71
    Regioni697 – 947Thioesterase (TE) domainSequence analysisAdd BLAST251

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1200.10, 1 hit
    3.40.50.12780, 1 hit
    3.40.50.1820, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029058 AB_hydrolase
    IPR036736 ACP-like_sf
    IPR020845 AMP-binding_CS
    IPR000873 AMP-dep_Synth/Lig
    IPR042099 AMP-dep_Synthh-like_sf
    IPR020802 PKS_thioesterase
    IPR009081 PP-bd_ACP
    IPR001031 Thioesterase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00501 AMP-binding, 1 hit
    PF00550 PP-binding, 1 hit
    PF00975 Thioesterase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00824 PKS_TE, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47336 SSF47336, 1 hit
    SSF53474 SSF53474, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00455 AMP_BINDING, 1 hit
    PS50075 CARRIER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    B7STY1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAPTAVFSNP ATNPVANLKA SVKTAEGVPA TLNDLLLQAT EMYPSHELSF
    60 70 80 90 100
    ITSSAHDSSV QARTFQDFNQ RVRNLASALA AWKKPAGEVV VVYLTEHEDN
    110 120 130 140 150
    MSAVWACLLA GLVPCLQPAL SAQQEHKEGH IAHIRKLFGS ATWLTNDAGA
    160 170 180 190 200
    MQLDTIKGLD VHLFSDLLAS AEKSSVAANY VARQSQPDDE AILFLTSGST
    210 220 230 240 250
    GFSKAVVHTH RTIINACIAK GANYRLTPQT NILNWVGFDH VAGSLEMHIA
    260 270 280 290 300
    PLLYGCSQLH VHASAILSDP LLLLRLIDER SIDIAFAPNF LLAKMVRDLE
    310 320 330 340 350
    KRTDLHGKFD LSSLRRMNSG GEAVVSKTAV AFVQLLKKLG RNPSKVSFKV
    360 370 380 390 400
    AAGFGMTETC AGCIYDVVDL AENSPKHEFL ALGAPVHGCE MRIVDPEDGA
    410 420 430 440 450
    TPRSDGQPGE LQVRGPMIFV RYYNNPEATK SSFVEGGWYR TGDIGIIENG
    460 470 480 490 500
    NMRLSGRIKD TVIVHGVSYG IPELETYLQT VQGVTHSFLA AAPYRAPGQE
    510 520 530 540 550
    TEGFVVFYAP TFDLQGDDAS KKLSETHRAI KDVSVKMMTL PPQHIVPIPM
    560 570 580 590 600
    DQMEKTTLGK LSRARLLSQF VQGALAKHVA RAEELISMAR GASFVTPSTD
    610 620 630 640 650
    DEKALAAIYA GIFNLQSNEV SARDNFFELG GTSIDVIRLK REGEAHFGLS
    660 670 680 690 700
    EIPIIQILKN PIVSDLAKYV NGLVNNDASA NEYDPIVPLQ LSGDKTPIFF
    710 720 730 740 750
    VHPGVGEVLI FVNLAKYFQN ERPFYAFRAR GFEPGHPFFG SMDEMVTSYA
    760 770 780 790 800
    NAMKKTQPKG PYAIAGYSYG GVVAFEVAKR LESMGEEVKF VGLINIPPHI
    810 820 830 840 850
    ADRMHEIDWT GGMLNLAYFL SLVTKQDATD LHPKLKTMTK EEQLEVVWKL
    860 870 880 890 900
    APPERVTELQ LTPGKLDHWV SIAGSLIECG KSYNPGGNVS AVDVFYAIPL
    910 920 930 940 950
    KGSKEDWLNK QLKPWSQFSR GEPQFIDVPG QHYTLMDFDH VPQFQKIFRG

    RLEARGL
    Length:957
    Mass (Da):105,038
    Last modified:February 10, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i473D0BBFF8F3B527
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    EU711405 Genomic DNA Translation: ACH90386.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    EU711405 Genomic DNA Translation: ACH90386.1

    3D structure databases

    SMRiB7STY1
    ModBaseiSearch...

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18722

    Family and domain databases

    Gene3Di1.10.1200.10, 1 hit
    3.40.50.12780, 1 hit
    3.40.50.1820, 1 hit
    InterProiView protein in InterPro
    IPR029058 AB_hydrolase
    IPR036736 ACP-like_sf
    IPR020845 AMP-binding_CS
    IPR000873 AMP-dep_Synth/Lig
    IPR042099 AMP-dep_Synthh-like_sf
    IPR020802 PKS_thioesterase
    IPR009081 PP-bd_ACP
    IPR001031 Thioesterase
    PfamiView protein in Pfam
    PF00501 AMP-binding, 1 hit
    PF00550 PP-binding, 1 hit
    PF00975 Thioesterase, 1 hit
    SMARTiView protein in SMART
    SM00824 PKS_TE, 1 hit
    SUPFAMiSSF47336 SSF47336, 1 hit
    SSF53474 SSF53474, 1 hit
    PROSITEiView protein in PROSITE
    PS00455 AMP_BINDING, 1 hit
    PS50075 CARRIER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRA_TAPPA
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7STY1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
    Last sequence update: February 10, 2009
    Last modified: September 18, 2019
    This is version 27 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
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