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Entry version 66 (05 Jun 2019)
Sequence version 1 (10 Feb 2009)
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Protein
Submitted name:

Dock-9, putative

Gene

8032985

Organism
Ixodes scapularis (Black-legged tick) (Deer tick)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dock-9, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:8032985Imported
ORF Names:IscW_ISCW020740Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiIxodes scapularis (Black-legged tick) (Deer tick)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6945 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeIxodinaeIxodes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001555 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 391PHInterPro annotationAdd BLAST115
Domaini780 – 962DHR-1InterPro annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 571DisorderedSequence analysisAdd BLAST24
Regioni1338 – 1389DisorderedSequence analysisAdd BLAST52
Regioni1420 – 1447DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi549 – 566PolarSequence analysisAdd BLAST18
Compositional biasi1368 – 1389PolarSequence analysisAdd BLAST22
Compositional biasi1420 – 1436PolarSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMWI Eukaryota
ENOG410ZVF7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B7PXX9

KEGG Orthology (KO)

More...
KOi
K21853

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAQHIGH

Database of Orthologous Groups

More...
OrthoDBi
20156at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B7PXX9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR027007 DHR-1_domain
IPR026791 DOCK
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7PXX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERKFTRAL SKPGTAAQAR ETVSQAVRES TELVRHHLVE PLDYELFVSK
60 70 80 90 100
NKTILQNDPQ REMLFFPMDD ISVSGYQTFA HIEICCSDGM VVLDVTLVSS
110 120 130 140 150
LRICTLKARL NRIGTISVNG HGCRQLGQGL AQSPSGCSSS LPRDASGIVP
160 170 180 190 200
AIRGPAGRTL SVGCVIKGIG FESGRKLMCC EKYITETQEV IPRANRTTVP
210 220 230 240 250
TIPSNMCFDS LPLFVRQCIK TYTADWHTVV YRFSAYSGTY KELLRLPRPT
260 270 280 290 300
DLQDQVYEVD TETEVKDSDN NTKGDSEIIK EGYILKGPES GTDSFISLAT
310 320 330 340 350
KSFKRRYLTL RREVDGTHIL EFFKDDKRSD SKGTICMDFC SKVVRNSKRS
360 370 380 390 400
KLSFELRMQD GHKSCVLRRR ARWRWTDGWP CWWPSLPTTG TPWRAARSRS
410 420 430 440 450
SPQKVTSSFQ KLSREGKDSC RERTLVGGAA YKPKTTVHTL PSNTSALVRK
460 470 480 490 500
SYYTATKYFS SYDGNQVTNY ERSVEPYKEE FNTRLFVRCE EVRFKLQAPL
510 520 530 540 550
DCEKVPCVTQ VEPYITTMSV YDVRRMRKVS EDFRFDVNNA YLRNMLPKTM
560 570 580 590 600
RRKSNSGSSN GTAAQPSPPA EPILPGISEL GEEWLAFPKQ VWVGRVSAVF
610 620 630 640 650
TVQRPEPELF LVVRIEKVLQ GNIAQASEPY LRHGSLGDAK QGTKAQKLVR
660 670 680 690 700
TCCQRLGHYR MPFAWAAKAI FTRFSCELDK SLDFGHIYRH DSAKLSEEDI
710 720 730 740 750
LKFLFDLRRP EKAKHFTVIP GQITVTLKSL KPDDQIENSL TPSLVPVEPF
760 770 780 790 800
PIPPKRDPTL EIQQFPTEVA ADSHPFCSYL NHLYVYPRSL KYDSQKTFAK
810 820 830 840 850
LCAKARTIVA RYKRSAKARG RLMEIQKNMN LEPLQDPMFI QGECVHIPVH
860 870 880 890 900
TCPNAMQVKI GLPLDLHDKH HLLFTFYHVS CDMVKATKRK DGPVETVVGY
910 920 930 940 950
SWLPLLNKGR LNIEEGILPV ASNLPAGYLS FKPLGLGKGF CGPDVRMVEG
960 970 980 990 1000
GRELFKVGFK LVSTVHTKDQ HLQNFFVHCQ KLLETKILGP DTETSTLLKA
1010 1020 1030 1040 1050
LHAVEGNAMV HFLPTVLNQL LRLIVSTGSE EVALNTVRVL IHLVTCVHEA
1060 1070 1080 1090 1100
GKEDVLHSYF MFVTEPPEGS QQTTVHEELA KSLAALLGPD NADFLVVHKF
1110 1120 1130 1140 1150
LHQSWFFFQI LAKSMAQHLM NTDRIKMQRH ERFSQEYHNR VRTLVNAVMP
1160 1170 1180 1190 1200
HILHKFKDLR NETRQANQGL AHFLKRCFSL MDRGFVFKLI NSYLEKFKSG
1210 1220 1230 1240 1250
DEMELHCYKF EFLEIICSHE HFIALNLPSL KGTYSRGHSK NTKGRYRLSE
1260 1270 1280 1290 1300
EFCRSHFLVG ALLLELRAAL SEVQKVRQRA IGVVCNLLAK HAFDDRYQGP
1310 1320 1330 1340 1350
AQQARIASLY LPLISVLLSN INRFSTSDQQ AAPACHAAGA SCATSPSRKT
1360 1370 1380 1390 1400
SKADSLNHMP DEPGTPPSGV SYRNSMMVDG PSSLPGSTRH NRDSNYLSII
1410 1420 1430 1440 1450
AGQVPVPHMG VTFANGSCTS LESESSTPSS SSAKDVEPAM RNGDNGSLPF
1460 1470 1480 1490 1500
ASHTGVVRYD KFEPAEIKDL LICFLYIIKQ LNEDLLIGWW QQCRECDLLD
1510 1520 1530 1540 1550
FFHLLELCLH QFRYMGKKHI LRGRKRQRRR TLCMTCKVGI AEEINVAKIT
1560 1570 1580 1590 1600
MVERAASVCF GTTAENGVDG VDGDSFYRAL LEANMATEVG LIALDVLGLY
1610 1620 1630 1640 1650
CGRFKDALLF NDGDNPVMRR LFDIYLSFLE VGQSENLLRH LFAALRAFIN
1660 1670
KFPVALFQGN AFLCGKLCFE VGFNVKYV
Length:1,678
Mass (Da):189,443
Last modified:February 10, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08C40DBEF1AD8D24
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABJB010001686 Genomic DNA No translation available.
ABJB010266916 Genomic DNA No translation available.
ABJB010303251 Genomic DNA No translation available.
ABJB010322129 Genomic DNA No translation available.
ABJB010355125 Genomic DNA No translation available.
ABJB010582024 Genomic DNA No translation available.
ABJB010728719 Genomic DNA No translation available.
ABJB010940922 Genomic DNA No translation available.
ABJB010978384 Genomic DNA No translation available.
ABJB011100636 Genomic DNA No translation available.
DS816731 Genomic DNA Translation: EEC11451.1

NCBI Reference Sequences

More...
RefSeqi
XP_002402049.1, XM_002402005.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ISCW020740-RA; ISCW020740-PA; ISCW020740

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8032985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
isc:IscW_ISCW020740

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
ISCW020740-RA; ISCW020740-PA; ISCW020740

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABJB010001686 Genomic DNA No translation available.
ABJB010266916 Genomic DNA No translation available.
ABJB010303251 Genomic DNA No translation available.
ABJB010322129 Genomic DNA No translation available.
ABJB010355125 Genomic DNA No translation available.
ABJB010582024 Genomic DNA No translation available.
ABJB010728719 Genomic DNA No translation available.
ABJB010940922 Genomic DNA No translation available.
ABJB010978384 Genomic DNA No translation available.
ABJB011100636 Genomic DNA No translation available.
DS816731 Genomic DNA Translation: EEC11451.1
RefSeqiXP_002402049.1, XM_002402005.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiISCW020740-RA; ISCW020740-PA; ISCW020740
GeneIDi8032985
KEGGiisc:IscW_ISCW020740
VectorBaseiISCW020740-RA; ISCW020740-PA; ISCW020740

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8032985

Phylogenomic databases

eggNOGiENOG410IMWI Eukaryota
ENOG410ZVF7 LUCA
InParanoidiB7PXX9
KOiK21853
OMAiCAQHIGH
OrthoDBi20156at2759
PhylomeDBiB7PXX9

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR027007 DHR-1_domain
IPR026791 DOCK
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7PXX9_IXOSC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7PXX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: June 5, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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