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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

ISCW003308

Organism
Ixodes scapularis (Black-legged tick) (Deer tick)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei223NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 198ATPUniRule annotation5
Nucleotide bindingi213 – 222ATPUniRule annotation10

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
ORF Names:ISCW003308
OrganismiIxodes scapularis (Black-legged tick) (Deer tick)
Taxonomic identifieri6945 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeIxodinaeIxodes
Proteomesi
  • UP000001555 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161671 – 303ATP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST303

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi6945.ISCW003308-PA

Structurei

3D structure databases

ProteinModelPortaliB7PBI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 299YjeF C-terminalUniRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 164NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3974 Eukaryota
COG0063 LUCA
InParanoidiB7PBI5
KOiK17757
OMAiNLMVHPL
OrthoDBiEOG091G0CC8
PhylomeDBiB7PBI5

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01049 YJEF_C_1, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

B7PBI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPHVPEGCS VQQQLVCSVI PPLNSERRKG QAGRVGIVGG SAEYTGAPYF
60 70 80 90 100
AAMAALRTGA DLVHVFCHPS AATAIKAYSP ELIVHPTLDA AVTCLPRLHA
110 120 130 140 150
VVVGPGLGRD VEASWMPTLF NRIREQGLPV VVDADGLFYV TQNPDLVRGY
160 170 180 190 200
SRAILTPNAV ELDRLYRAVL GSPPRENAVP ELARALGHVT VLAKGSEDII
210 220 230 240 250
SDGHRLLRCT EQGSPRRCGG QGDLVSGSLA LFAFWSHSAH DTPGEASKRQ
260 270 280 290 300
NSEYGPAMIA ALGAAMLVRR CGRLAFQKMA RSTLSSDMLA EVRTAFSMLF

PVD
Length:303
Mass (Da):32,363
Last modified:February 10, 2009 - v1
Checksum:i3D5A370E9F3EE512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS676278 Genomic DNA Translation: EEC03957.1
RefSeqiXP_002408179.1, XM_002408135.1
UniGeneiIsc.23663

Genome annotation databases

EnsemblMetazoaiISCW003308-RA; ISCW003308-PA; ISCW003308
GeneIDi8027421
KEGGiisc:IscW_ISCW003308
VectorBaseiISCW003308-RA; ISCW003308-PA; ISCW003308

Similar proteinsi

Entry informationi

Entry nameiNNRD_IXOSC
AccessioniPrimary (citable) accession number: B7PBI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: February 10, 2009
Last modified: April 25, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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