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Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 3 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (mtnB)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Metal bindingi73ZincUniRule annotation1
Metal bindingi92ZincUniRule annotation1
Metal bindingi94ZincUniRule annotation1
Active sitei113Proton donorUniRule annotation1
Metal bindingi155ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processCarbohydrate metabolism, Fucose metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00563; UER00626

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
Alternative name(s):
L-fuculose-1-phosphate aldolaseUniRule annotation
Gene namesi
Name:fucAUniRule annotationImported
Ordered Locus Names:ECUMN_3129Imported
OrganismiEscherichia coli O17:K52:H18 (strain UMN026 / ExPEC)Imported
Taxonomic identifieri585056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000007097 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7N734
SMRiB7N734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 182Aldolase_IIInterPro annotationAdd BLAST175

Sequence similaritiesi

Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218184
KOiK01628
OMAiLCEQYWR

Family and domain databases

Gene3Di3.40.225.10, 1 hit
HAMAPiMF_00987 FucA, 1 hit
InterProiView protein in InterPro
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
IPR004782 FucA
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit
TIGRFAMsiTIGR01086 fucA, 1 hit

Sequencei

Sequence statusi: Complete.

B7N734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL
60 70 80 90 100
TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA
110 120 130 140 150
VSILNRPIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT
160 170 180 190 200
LLQHHGLIAC EVNLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA
210
VVLEKFKTYG LRIEE
Length:215
Mass (Da):23,785
Last modified:February 10, 2009 - v1
Checksum:i072E4EC5A94E76D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928163 Genomic DNA Translation: CAR14295.1
RefSeqiWP_000440775.1, NC_011751.1
YP_002413815.1, NC_011751.1

Genome annotation databases

EnsemblBacteriaiCAR14295; CAR14295; ECUMN_3129
GeneIDi7156472
KEGGieum:ECUMN_3129
PATRICifig|585056.7.peg.3310

Similar proteinsi

Entry informationi

Entry nameiB7N734_ECOLU
AccessioniPrimary (citable) accession number: B7N734
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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