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UniProtKB - B7MWY8 (MDTB_ECO81)

Entry version 66 (02 Dec 2020)
Sequence version 1 (10 Feb 2009)
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Protein

Multidrug resistance protein MdtB

Gene

mdtB

Organism
Escherichia coli O81 (strain ED1a)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance protein MdtBUniRule annotation
Alternative name(s):
Multidrug transporter MdtBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdtBUniRule annotation
Ordered Locus Names:ECED1_2421
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O81 (strain ED1a)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri585397 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000748 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei347 – 367HelicalUniRule annotationAdd BLAST21
Transmembranei369 – 389HelicalUniRule annotationAdd BLAST21
Transmembranei396 – 416HelicalUniRule annotationAdd BLAST21
Transmembranei440 – 460HelicalUniRule annotationAdd BLAST21
Transmembranei472 – 492HelicalUniRule annotationAdd BLAST21
Transmembranei537 – 557HelicalUniRule annotationAdd BLAST21
Transmembranei863 – 883HelicalUniRule annotationAdd BLAST21
Transmembranei888 – 908HelicalUniRule annotationAdd BLAST21
Transmembranei911 – 931HelicalUniRule annotationAdd BLAST21
Transmembranei968 – 988HelicalUniRule annotationAdd BLAST21
Transmembranei998 – 1018HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_10001848661 – 1040Multidrug resistance protein MdtBAdd BLAST1040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The mdtABC operon is transcriptionally activated by BaeR.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B7MWY8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002755_1_2_6

Identification of Orthologs from Complete Genome Data

More...OMAi		FIIPCFY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.2090.10, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_01423, MdtB, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
IPR022831, Multidrug-R_MdtB

The PANTHER Classification System

More...PANTHERi		PTHR32063, PTHR32063, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00873, ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00702, ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82714, SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7MWY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVLPPSSTG GPSRLFIMRP VATTLLMVAI LLAGIIGYRA LPVSALPEVD 
        60         70         80         90        100
YPTIQVVTLY PGASPDVMTS AVTAPLERQF GQMSGLKQMS SQSSGGASVI 
       110        120        130        140        150
TLQFQLTLPL DVAEQEVQAA INAATNLLPS DLPNPPVYSK VNPADPPIMT 
       160        170        180        190        200
LAVTSTAMPM TQVEDMVETR VAQKISQISG VGLVTLSGGQ RPAVRVKLNA 
       210        220        230        240        250
QAIAALGLTS ETVRTAITGA NVNSAKGSLD GPSRAVTLSA NDQMQSAEEY 
       260        270        280        290        300
RQLIIAYQNG APIRLGDVAT VEQGAENSWL GAWANKEQAI VMNVQRQPGA 
       310        320        330        340        350
NIISTADSIR QMLPQLTESL PKSVKVTVLS DRTTNIRASV DDTQFELMMA 
       360        370        380        390        400
IALVVMIIYL FLRNIPATII PGVAVPLSLI GTFAVMVFLD FSINNLTLMA 
       410        420        430        440        450
LTIATGFVVD DAIVVIENIS RYIEKGEKPL AAALKGAGEI GFTIISLTFS 
       460        470        480        490        500
LIAVLIPLLF MGDIVGRLFR EFAITLAVAI LISAVVSLTL TPMMCARMLS 
       510        520        530        540        550
QESLRKQNRF SRASEKMFDR IIAAYGRGLA KVLNHPWLTL SVALSTLLLS 
       560        570        580        590        600
VLLWVFIPKG FFPVQDNGII QGTLQAPQSS SFANMAQRQR QVADVILQDP 
       610        620        630        640        650
AVQSLTSFVG VDGTNPSLNS ARLQINLKPL DERDDRVQKV IARLQTAVDK 
       660        670        680        690        700
VPGVDLFLQP TQDLTIDTQV SRTQYQFTLQ ATSLDALSTW VPQLMEKLQQ 
       710        720        730        740        750
LPQLSDVSSD WQDKGLVAYV NVDRDSASRL GISMADVDNA LYNAFGQRLI 
       760        770        780        790        800
STIYTQANQY RVVLEHNTEN TPGLAALDTI RLTSSDGGVV PLSSIAKIEP 
       810        820        830        840        850
RFAPLSINHL DQFPVTTISF NVPDNYSLGD AVQAIMDTEK TLNLPVDITT 
       860        870        880        890        900
QFQGSTLAFQ SALGSTVWLI VAAVVAMYIV LGILYESFIH PITILSTLPT 
       910        920        930        940        950
AGVGALLALM IAGSELDVIA IIGIILLIGI VKKNAIMMID FALAAEREQG 
       960        970        980        990       1000
MSPREAIYQA CLLRFRPILM TTLAALLGAL PLMLSTGVGA ELRRPLGIGM 
      1010       1020       1030       1040
VGGLIVSQVL TLFTTPVIYL LFDRLALWTK SRFARHEEEA
Length:1,040
Mass (Da):112,065
Last modified:February 10, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB86C211C5A11AB46
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU928162 Genomic DNA Translation: CAR08604.2

NCBI Reference Sequences

More...RefSeqi		WP_001197873.1, NC_011745.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAR08604; CAR08604; ECED1_2421

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecq:ECED1_2421

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928162 Genomic DNA Translation: CAR08604.2
RefSeqiWP_001197873.1, NC_011745.1

3D structure databases

SMRiB7MWY8
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiCAR08604; CAR08604; ECED1_2421
KEGGiecq:ECED1_2421

Phylogenomic databases

HOGENOMiCLU_002755_1_2_6
OMAiFIIPCFY

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
HAMAPiMF_01423, MdtB, 1 hit
InterProiView protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
IPR022831, Multidrug-R_MdtB
PANTHERiPTHR32063, PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873, ACR_tran, 1 hit
PRINTSiPR00702, ACRIFLAVINRP
SUPFAMiSSF82714, SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDTB_ECO81
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7MWY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: December 2, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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