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UniProtKB - B7M562 (MDTL_ECO8A)
Protein
Multidrug resistance protein MdtL
Gene
mdtL
Organism
Escherichia coli O8 (strain IAI1)
Status
Functioni
Confers resistance to chloramphenicol.
UniRule annotationGO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein MdtLUniRule annotation |
Gene namesi | Name:mdtLUniRule annotation Ordered Locus Names:ECIAI1_3890 |
Organismi | Escherichia coli O8 (strain IAI1) |
Taxonomic identifieri | 585034 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 69 – 89 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 203 – 222 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 245 – 265 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 269 – 289 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 293 – 313 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 331 – 351 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 356 – 376 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000200823 | 1 – 391 | Multidrug resistance protein MdtLAdd BLAST | 391 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_001265_47_1_6 |
OMAi | AGSCYVV |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
B7M562-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRFLICSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG
60 70 80 90 100
MAAAMLFAGK VADRSGRKPV AIPGAALFII ASVFCSLAET STLFLAGRFL
110 120 130 140 150
QGLGAGCCYV VAFAILRDTL DDRRRAKVLS LLNGITCIIP VLAPVLGHLI
160 170 180 190 200
MLKFPWQSLF WTMAMMGIAV LMLSLFILKE TRPASPAASD KPRENSESLL
210 220 230 240 250
NRFFLSRVVI TTLSVSVILT FVNTSPVLLM EIMGFERGEY ATIMALTAGV
260 270 280 290 300
SMTVSFSTPF ALGIFKPRTL MITSQVLFLA AGITLAVSPS HAVSLFGITL
310 320 330 340 350
ICAGFSVGFG VAMSQALGPF SLRAGVASST LGIAQVCGSS LWIWLAAVVG
360 370 380 390
IGAWNMLIGI LIACSIVSLL LIMFVAPGRP VAAHEEIHHH A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU928160 Genomic DNA Translation: CAR00684.1 |
RefSeqi | WP_000086001.1, NC_011741.1 |
Genome annotation databases
KEGGi | ecr:ECIAI1_3890 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU928160 Genomic DNA Translation: CAR00684.1 |
RefSeqi | WP_000086001.1, NC_011741.1 |
3D structure databases
AlphaFoldDBi | B7M562 |
SMRi | B7M562 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ecr:ECIAI1_3890 |
Phylogenomic databases
HOGENOMi | CLU_001265_47_1_6 |
OMAi | AGSCYVV |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTL_ECO8A | |
Accessioni | B7M562Primary (citable) accession number: B7M562 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |