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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Bacillus cereus (strain AH820)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotationSAAS annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
  2. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
  3. 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
  5. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG)
  6. 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH)
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121SubstrateUniRule annotation1
Metal bindingi146Divalent metal cationUniRule annotation1
Metal bindingi148Divalent metal cationUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Metal bindingi217Divalent metal cationUniRule annotation1
Binding sitei217SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 36NADPUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseImported, OxidoreductaseUniRule annotationSAAS annotationImported
Biological processIsoprene biosynthesisUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00056; UER00092

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotationSAAS annotation (EC:1.1.1.267UniRule annotationSAAS annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
Gene namesi
Name:dxrUniRule annotation
Synonyms:dxr2Imported
Ordered Locus Names:BCAH820_3833Imported
OrganismiBacillus cereus (strain AH820)Imported
Taxonomic identifieri405535 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001363 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliB7JJ99
SMRiB7JJ99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 128DXP_reductoisomInterPro annotationAdd BLAST125
Domaini142 – 225DXP_redisom_CInterPro annotationAdd BLAST84
Domaini257 – 374DXPR_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the DXR family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000007220
KOiK00099
OMAiDSEHFGL

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
PIRSFiPIRSF006205 Dxp_reductismrs, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit

Sequencei

Sequence statusi: Complete.

B7JJ99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNISLLGAS GSIGTQTLDV LRSHPDQFRL VAFSVGKNID YAVKVIQEFS
60 70 80 90 100
PQIVSVQREE DVLKLQAVSG NTKIVYGSEG LLEVALHPDA EIVVNAVVGS
110 120 130 140 150
VGLLPTLRAI EAKKTIGIAN KETLVTAGHL VMEAARKHNV SLLPVDSEHS
160 170 180 190 200
AIFQCLNGEN EKRISRLIIT ASGGSFRDKT RDELHHVTVE DALRHPNWSM
210 220 230 240 250
GSKITIDSAT MMNKGLEVIE AHWLFGIPYE QIDVVLHKES IIHSMVEFED
260 270 280 290 300
RSVMAQLGSP DMRVPIQYAL TYPDRLPLSD TKQLNLWEIG TLHFEKMNQE
310 320 330 340 350
RFRCLRFAYE AGKAGGSMPA VMNAANEVAV EAFLQKRIGF LTVEDLIEKA
360 370 380
MNHHNVIARP SLEEILEIDA ATRRFVMEQI
Length:380
Mass (Da):42,239
Last modified:February 10, 2009 - v1
Checksum:i689DDF159E83D1B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001283 Genomic DNA Translation: ACK89773.1
RefSeqiWP_000790359.1, NC_011773.1

Genome annotation databases

EnsemblBacteriaiACK89773; ACK89773; BCAH820_3833
KEGGibcu:BCAH820_3833

Similar proteinsi

Entry informationi

Entry nameiB7JJ99_BACC0
AccessioniPrimary (citable) accession number: B7JJ99
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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