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Entry version 52 (11 Dec 2019)
Sequence version 1 (10 Feb 2009)
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Protein
Submitted name:

Transporter, AcrB/AcrD/AcrF family

Gene

AFE_2104

Organism
Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270))
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AFER243159:G1GU1-1971-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transporter, AcrB/AcrD/AcrF familyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:AFE_2104Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAcidithiobacilliaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001362 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
B7J4W3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
243159.AFE_2104

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158127

Identification of Orthologs from Complete Genome Data

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OMAi
VYAMRVW

Database of Orthologous Groups

More...
OrthoDBi
145346at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7J4W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLSAPFIRR PVATTVLAVA VALLGLFAYL QLPTALLPNV SFPMVMVTAE
60 70 80 90 100
LPGASPKTMS SAVATPLERQ FASIPGLNSM SAVSQNGVTQ ITLQFDLSKS
110 120 130 140 150
PLGATQQVSN AVSQAQHFLP PGMPEPPSVR QMNPSAQPVF YIGMSAPNMP
160 170 180 190 200
LYDLDKYAQT KVSTALSGIS GVSDVQIYGA QTYAVRIYVN PFALSARGLS
210 220 230 240 250
LQAVQSALGN ANVNLPGGTL DGGDQAFATQ VHGQLHTAEA YNHLVLAYEG
260 270 280 290 300
GQAVPLSAVG KAVNSTQDNQ QETWINKTPG IVLAVTRQPG SNTVAISNKI
310 320 330 340 350
RAMLPQLQAA MPGGVHLTNV FDLADYIRAA VHEVLMTLIL ASILVAGVMW
360 370 380 390 400
LFLRRPSATL IGAVAIPLSL LGTFLVMMLL GFSINTLTLL ALTLSVGFVV
410 420 430 440 450
DDAVVMLENI NRHIDRGETG MTAALNGSRE ISFTVLSMTL SLSIIFLPLI
460 470 480 490 500
FLGGFVGHLF SDFGVSIAVV ILISGMVALS VTPMLCSRYL KPNHAHTPTD
510 520 530 540 550
LHDTGHLPED GIFQRFFKGS RDFYIRTLKV ALQHKYWMLA LAGLSLAGSV
560 570 580 590 600
WLVMIVPKAF LPSQNSGMIN ANIEYPTGMT FAEVSHEQSE IARVVKSNPR
610 620 630 640 650
IQSVVSSAGQ GPGGFGSSTS GHMFIHIRNG YAPETEEIIE DLNRATQGFH
660 670 680 690 700
NAQVVFQGPQ SAHSGTASDN GSYVYELIGN NWTDLNAATL RMTAALRRLP
710 720 730 740 750
QLSSVSNSLQ NNNPQVAIKI NRPWATALGV TPAAIENTLG LAFGGHEVGT
760 770 780 790 800
IYGANDQYEV IMELEPRYQH NINALSTLSV AGAGGTLVPL SAVAEFHYDA
810 820 830 840 850
APLTLMQHNG QPSTTISFNL APGANLGRAI SALQSKAKDI LPAGIAGHLG
860 870 880 890 900
GTAAQFQSAF KSLPFLLLAT VLLIYVVLAI LYEHFLHPLT ILTALPLAAF
910 920 930 940 950
GALLSLVIFN EPLELYSFIG IIMLLGLVKK NGIILVDFAV SRRREGASAY
960 970 980 990 1000
EAIVDACTIR YRPIMMTTFA AILGVLPIAI GFGAGADSRV PLGIAVVGGL
1010 1020 1030
IFSQFLTLYI TPAFYLFFDE LQAAPKYFNW LFGR
Length:1,034
Mass (Da):110,365
Last modified:February 10, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1602D3F1FC298D4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001219 Genomic DNA Translation: ACK79869.1

NCBI Reference Sequences

More...
RefSeqi
WP_012536972.1, NC_011761.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACK79869; ACK79869; AFE_2104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afr:AFE_2104

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001219 Genomic DNA Translation: ACK79869.1
RefSeqiWP_012536972.1, NC_011761.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi243159.AFE_2104

Proteomic databases

PaxDbiB7J4W3

Genome annotation databases

EnsemblBacteriaiACK79869; ACK79869; AFE_2104
KEGGiafr:AFE_2104

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158127
OMAiVYAMRVW
OrthoDBi145346at2

Enzyme and pathway databases

BioCyciAFER243159:G1GU1-1971-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7J4W3_ACIF2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7J4W3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 11, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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