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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processSporulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:Aflv_1003
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001308011 – 146Anti-sigma F factorAdd BLAST146

Interactioni

Protein-protein interaction databases

STRINGi491915.Aflv_1003

Structurei

3D structure databases

SMRiB7GKG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
HOGENOMiHOG000269931
KOiK06379
OMAiHAYEDKI
OrthoDBiPOG091H0LCB

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00637 Anti_sigma_F, 1 hit
InterProiView protein in InterPro
IPR010194 Anti-sigma_F
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
PANTHERiPTHR35526:SF2 PTHR35526:SF2, 1 hit
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01925 spIIAB, 1 hit

Sequencei

Sequence statusi: Complete.

B7GKG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNEMHLQFS ALSQNESFAR VTVAAFVAQL DPTLDELTEI KTVVSEAVTN
60 70 80 90 100
AIIHGYENDP SGVVYISVII EGHTVHLTIR DHGKGIENVE EARQPLFTTK
110 120 130 140
PELERSGMGF TIMENFMDEV NIYSKVNEGT TVELIKHLTK SKALCN
Length:146
Mass (Da):16,291
Last modified:February 10, 2009 - v1
Checksum:i702AD7D900465EB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA Translation: ACJ33379.1
RefSeqiWP_004889709.1, NC_011567.1

Genome annotation databases

EnsemblBacteriaiACJ33379; ACJ33379; Aflv_1003
GeneIDi29574496
KEGGiafl:Aflv_1003

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA Translation: ACJ33379.1
RefSeqiWP_004889709.1, NC_011567.1

3D structure databases

SMRiB7GKG6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi491915.Aflv_1003

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ33379; ACJ33379; Aflv_1003
GeneIDi29574496
KEGGiafl:Aflv_1003

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
HOGENOMiHOG000269931
KOiK06379
OMAiHAYEDKI
OrthoDBiPOG091H0LCB

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00637 Anti_sigma_F, 1 hit
InterProiView protein in InterPro
IPR010194 Anti-sigma_F
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
PANTHERiPTHR35526:SF2 PTHR35526:SF2, 1 hit
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01925 spIIAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSP2AB_ANOFW
AccessioniPrimary (citable) accession number: B7GKG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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