UniProtKB - B7FSL4 (LONM_PHATC)
Protein
Lon protease homolog, mitochondrial
Gene
PHATRDRAFT_18202
Organism
Phaeodactylum tricornutum (strain CCAP 1055/1)
Status
Functioni
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.UniRule annotation
Catalytic activityi
- Hydrolysis of proteins in presence of ATP.UniRule annotation EC:3.4.21.53
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 784 | UniRule annotation | 1 | |
Active sitei | 827 | UniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 435 – 442 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ATP-dependent peptidase activity Source: UniProtKB-UniRule
- sequence-specific DNA binding Source: UniProtKB-UniRule
- serine-type endopeptidase activity Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to oxidative stress Source: UniProtKB-UniRule
- chaperone-mediated protein complex assembly Source: UniProtKB-UniRule
- oxidation-dependent protein catabolic process Source: UniProtKB-UniRule
- protein quality control for misfolded or incompletely synthesized proteins Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-binding, Hydrolase, Protease, Serine protease |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lon protease homolog, mitochondrialUniRule annotation (EC:3.4.21.53UniRule annotation) |
Gene namesi | ORF Names:PHATRDRAFT_18202 |
Organismi | Phaeodactylum tricornutum (strain CCAP 1055/1) |
Taxonomic identifieri | 556484 [NCBI] |
Taxonomic lineagei | Eukaryota › Stramenopiles › Bacillariophyta › Bacillariophyceae › Bacillariophycidae › Naviculales › Phaeodactylaceae › Phaeodactylum › |
Proteomesi |
|
Subcellular locationi
- Mitochondrion matrix UniRule annotation
GO - Cellular componenti
- mitochondrial matrix Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | MitochondrionUniRule annotationAdd BLAST | 34 | |
ChainiPRO_0000395770 | 35 – 882 | Lon protease homolog, mitochondrialAdd BLAST | 848 |
Proteomic databases
PRIDEi | B7FSL4 |
Interactioni
Subunit structurei
Homohexamer or homoheptamer. Organized in a ring with a central cavity.
UniRule annotationProtein-protein interaction databases
STRINGi | 2850.Phatr18202 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 279 | Lon N-terminalPROSITE-ProRule annotationAdd BLAST | 212 | |
Domaini | 687 – 878 | Lon proteolyticPROSITE-ProRule annotationAdd BLAST | 192 |
Sequence similaritiesi
Belongs to the peptidase S16 family.UniRule annotation
Keywords - Domaini
Transit peptidePhylogenomic databases
HOGENOMi | HOG000261409 |
InParanoidi | B7FSL4 |
KOi | K08675 |
OrthoDBi | 528132at2759 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit |
HAMAPi | MF_03120 lonm_euk, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR004815 Lon_bac/euk-typ IPR008269 Lon_proteolytic IPR027065 Lon_Prtase IPR003111 Lon_substr-bd IPR027503 Lonm_euk IPR027417 P-loop_NTPase IPR008268 Peptidase_S16_AS IPR015947 PUA-like_sf IPR020568 Ribosomal_S5_D2-typ_fold IPR014721 Ribosomal_S5_D2-typ_fold_subgr |
PANTHERi | PTHR43718 PTHR43718, 1 hit |
Pfami | View protein in Pfam PF00004 AAA, 1 hit PF05362 Lon_C, 1 hit PF02190 LON_substr_bdg, 1 hit |
PIRSFi | PIRSF001174 Lon_proteas, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit SM00464 LON, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit SSF54211 SSF54211, 1 hit SSF88697 SSF88697, 1 hit |
TIGRFAMsi | TIGR00763 lon, 1 hit |
PROSITEi | View protein in PROSITE PS51787 LON_N, 1 hit PS51786 LON_PROTEOLYTIC, 1 hit PS01046 LON_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
B7FSL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIHVLKSRST LLTASSIVRT SVGSSSRYSQ TRTYSRTHSW SKDASGGAIS
60 70 80 90 100
VLPTKLPFGE QAPRFPHTLG LPLVSRPLFP GLVTSVTLTD EATIDAMEAL
110 120 130 140 150
TKNQDQAYVS CFLRKKNPTG VSEGGVILAT PEVITDPSDI YHVGTFAQIQ
160 170 180 190 200
RLTRGDETAA TLILLAHRRL DLEYVDKIGP PIDVTVKHWN RSDYTGADDT
210 220 230 240 250
IRALSNEIIS TIREVAQVNM LFRENLQYFP MRVDANDPFR LADFAASISA
260 270 280 290 300
SGTPEDLQAV LEEKDAEMRL HKALVLLNRE REVSKLQQEI SQKVEERMTE
310 320 330 340 350
AQRKYFLTEQ LKSIKKELGM ERDDKDTLIE KYRKTLSEYP HVPEEAMETI
360 370 380 390 400
DAELEKFSTL EKNSPEYNVT RSYLDWLTSV PWGVETEENF DIQKARKTLD
410 420 430 440 450
RDHYGLDDVK DTILEFIAIG KLRGSVQGKI LCLSGPPGTG KTSIAKSVAD
460 470 480 490 500
ALGRQFFRFS VGGLSDVSEI KGHRRTYIGA MPGKLIQCLK ATGTTNPVVL
510 520 530 540 550
IDEIDKLGTG FRGDPASALL EVLDPGQNST FRDYFLDVPV DISKVLFICT
560 570 580 590 600
ANELERIPGP LLDRMEVIRL SGYDLPEKVA IAEQYLVPKS MRDSGLLGVP
610 620 630 640 650
ETLKLTIDAV RSLARWYARE AGVRNLAKYI DRITRKLALQ VVAESEGATL
660 670 680 690 700
TDKSSRKSNT WEITEDNLHE YVGKPVFTSD RLYEDGPLPH GIVMGLAYTS
710 720 730 740 750
MGGSALYIET QSIRRGLDSE GKTRGGGTLK VTGQLGDVMK ESTQIASTVA
760 770 780 790 800
RARLSDIKPE SNFFDINDIH MHVPEGATPK DGPSAGVTMV TSMLSLALDR
810 820 830 840 850
PIRNDLAMTG EVSLTGKVLA VGGIKEKIMG ARRAGIKCVI LPAANKRDYD
860 870 880
EIPDYLKEDL EVHYADTFDK VYEVAFSSVD ST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000606 Genomic DNA Translation: EEC50499.1 |
RefSeqi | XP_002177685.1, XM_002177649.1 |
Genome annotation databases
GeneIDi | 7197221 |
KEGGi | pti:PHATRDRAFT_18202 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000606 Genomic DNA Translation: EEC50499.1 |
RefSeqi | XP_002177685.1, XM_002177649.1 |
3D structure databases
SMRi | B7FSL4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 2850.Phatr18202 |
Proteomic databases
PRIDEi | B7FSL4 |
Genome annotation databases
GeneIDi | 7197221 |
KEGGi | pti:PHATRDRAFT_18202 |
Phylogenomic databases
HOGENOMi | HOG000261409 |
InParanoidi | B7FSL4 |
KOi | K08675 |
OrthoDBi | 528132at2759 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit |
HAMAPi | MF_03120 lonm_euk, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR004815 Lon_bac/euk-typ IPR008269 Lon_proteolytic IPR027065 Lon_Prtase IPR003111 Lon_substr-bd IPR027503 Lonm_euk IPR027417 P-loop_NTPase IPR008268 Peptidase_S16_AS IPR015947 PUA-like_sf IPR020568 Ribosomal_S5_D2-typ_fold IPR014721 Ribosomal_S5_D2-typ_fold_subgr |
PANTHERi | PTHR43718 PTHR43718, 1 hit |
Pfami | View protein in Pfam PF00004 AAA, 1 hit PF05362 Lon_C, 1 hit PF02190 LON_substr_bdg, 1 hit |
PIRSFi | PIRSF001174 Lon_proteas, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit SM00464 LON, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit SSF54211 SSF54211, 1 hit SSF88697 SSF88697, 1 hit |
TIGRFAMsi | TIGR00763 lon, 1 hit |
PROSITEi | View protein in PROSITE PS51787 LON_N, 1 hit PS51786 LON_PROTEOLYTIC, 1 hit PS01046 LON_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LONM_PHATC | |
Accessioni | B7FSL4Primary (citable) accession number: B7FSL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 8, 2019 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families