UniProtKB - B7FDP2 (SCX39_CENSU)
Protein
Toxin Css39.8
Gene
N/A
Organism
Centruroides suffusus (Durango bark scorpion)
Status
Functioni
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp.)), it provokes a reversible paralysis to insects (crickets (Achaeta spp.)), but is not toxic to mice. At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes.1 Publication
GO - Molecular functioni
- sodium channel inhibitor activity Source: UniProtKB
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response Source: InterPro
- pathogenesis Source: UniProtKB
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Toxin Css39.8 |
Organismi | Centruroides suffusus (Durango bark scorpion) |
Taxonomic identifieri | 6880 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 28.5 mg/g body weight of crayfish.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_5000417205 | 20 – 85 | Toxin Css39.8Add BLAST | 66 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 84 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 35 ↔ 60 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 44 ↔ 65 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 48 ↔ 67 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 85 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR003614 Scorpion_toxin-like IPR036574 Scorpion_toxin-like_sf IPR018218 Scorpion_toxinL IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
PRINTSi | PR00285 SCORPNTOXIN |
SMARTi | View protein in SMART SM00505 Knot1, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
B7FDP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSLLMITAC FFLIGTVWAK EGYLVNKSTG CKYGCLLLGK NEGCDKECKA
60 70 80
KNQGGSYGYC YAFGCWCEGL PESTPTYPLP NKSCSKK
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM981271 mRNA Translation: CAQ37795.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM981271 mRNA Translation: CAQ37795.1 |
3D structure databases
SMRi | B7FDP2 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR003614 Scorpion_toxin-like IPR036574 Scorpion_toxin-like_sf IPR018218 Scorpion_toxinL IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
PRINTSi | PR00285 SCORPNTOXIN |
SMARTi | View protein in SMART SM00505 Knot1, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | SCX39_CENSU | |
Accessioni | B7FDP2Primary (citable) accession number: B7FDP2 Secondary accession number(s): P85522 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 19, 2010 |
Last sequence update: | February 10, 2009 | |
Last modified: | December 5, 2018 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families