Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modifier of cell death

Gene

mcd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes programmed cell death. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri259 – 282C2H2-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • nematode larval development Source: WormBase
  • positive regulation of growth rate Source: WormBase
  • programmed cell death Source: WormBase

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Modifier of cell deathImported
Gene namesi
Name:mcd-1Imported
ORF Names:Y51H1A.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY51H1A.6a ; CE43312 ; WBGene00013096 ; mcd-1
Y51H1A.6b ; CE43386 ; WBGene00013096 ; mcd-1

Pathology & Biotechi

Disruption phenotypei

Enhances the cell death defect of ced-3(n2427) mutants. Double knockout with the synthetic multivulva (synMuv) class B proteins lin-9, lin-15B, lin-35 or lin-54 results in 100% lethality during the L1 stage of larval development. Double knockout with the synMuv class B protein lin-53 results in slow larval growth.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi277H → Y in n3376; defective programmed cell death. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004410141 – 901Modifier of cell deathCuratedAdd BLAST901

Proteomic databases

EPDiB7FAS0
PaxDbiB7FAS0
PeptideAtlasiB7FAS0

Expressioni

Gene expression databases

BgeeiWBGene00013096
ExpressionAtlasiB7FAS0 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.Y51H1A.6a

Structurei

3D structure databases

SMRiB7FAS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 92Glu-richPROSITE-ProRule annotationAdd BLAST91
Compositional biasi813 – 868Glu-richPROSITE-ProRule annotationAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri259 – 282C2H2-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410K7HY Eukaryota
ENOG4110MCX LUCA
HOGENOMiHOG000021890
InParanoidiB7FAS0
OMAiHYDGNIG
OrthoDBiEOG091G07J3

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: B7FAS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METAPDEAPT EFLEPGEEIV ENVIEEEVVH EEDVEHHEED GEMIEVQHEE
60 70 80 90 100
VLEEIVEEDG MMFDTDGRVI EYSDVMVYEE GTEVIEEYVE VEDLGDGRYA
110 120 130 140 150
YVMTDDIGHR RLLKPHEVEA VKKMPGMMEE EVVMDDEKAP NTSYAAAQKR
160 170 180 190 200
GRFPPQARSS LSPQKPRAAG AYMGPEAYYQ QPKRMTHMAK VDVEKYSPVT
210 220 230 240 250
PVNRRPLMDN AIFKSKLPRK SAPWQEETAA NGGPQSTSLI RSPSPMLKEP
260 270 280 290 300
LFDDNEIRFK CAECGDGFPV MDRLCDHMIK QHDCQTNVRE VQFFADRDFE
310 320 330 340 350
NFLLKVEKAT LGRDPEDAIR KKSRAGSSQL FVCNYMNKGR QKMAELVEVG
360 370 380 390 400
IVGLSERPLE VCTAFVQKTH GYECIRVKYC DQHIHYDGNI GFRVPIAVKR
410 420 430 440 450
RLFEMSFKRL PIPCMQIMLG LEAEQLLPHP TRFEEKLKNL SHVEIIELLQ
460 470 480 490 500
IINASLRKHQ EVEPRGKKVP IKFETIKSSE GSQTLMVKRV TPPKKEHMDY
510 520 530 540 550
DEPDPNIPST SAQALGYNPD DDEGDDVPMM SREEEVLDDE TGEESVMTED
560 570 580 590 600
CDGMMEDNML YDPENNRDPL FDELTEVELG VLDAYEHDIE IALTEAQKKE
610 620 630 640 650
RTRLKAKFAL NKVIGIYQTL DTATHGLTAG ELHTDTINHL RDMASYVVEL
660 670 680 690 700
VCQIDAEVKV RRNPALRIDD VKRDMIAGIA MQERVHQPER RPRRSAAPAS
710 720 730 740 750
PAKPQYRPQP PARSHEEYTQ RIMNKVKEYM PRRRPDAYDL QQGQQQSRLQ
760 770 780 790 800
MLREQTLLRA PLEEEKPPVA TMAPVPDEHK AIPWTRPGRK RAMGPGEAAT
810 820 830 840 850
APAKRRGRPT KKEEAAEAAA KLIQAENEMV VEEEEVEEPP VVEQEQVPKE
860 870 880 890 900
KEVEVAEAEK LPEQVKTEPS VTPSSAPPTP ATTATKTRTG RVVKPKKWDD

N
Length:901
Mass (Da):102,644
Last modified:February 10, 2009 - v1
Checksum:iE6300EC14257A7E6
GO
Isoform bImported (identifier: B7FAS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-642: Missing.

Show »
Length:259
Mass (Da):29,287
Checksum:i04348B1EA2DF2C21
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0590211 – 642Missing in isoform b. CuratedAdd BLAST642

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAT01087.1
BX284602 Genomic DNA Translation: CAT01089.1
RefSeqiNP_001254412.1, NM_001267483.1 [B7FAS0-1]
NP_001254413.1, NM_001267484.1 [B7FAS0-2]
UniGeneiCel.13982

Genome annotation databases

EnsemblMetazoaiY51H1A.6a; Y51H1A.6a; WBGene00013096 [B7FAS0-1]
Y51H1A.6b.1; Y51H1A.6b.1; WBGene00013096 [B7FAS0-2]
Y51H1A.6b.2; Y51H1A.6b.2; WBGene00013096 [B7FAS0-2]
GeneIDi175040
KEGGicel:CELE_Y51H1A.6

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMCD1_CAEEL
AccessioniPrimary (citable) accession number: B7FAS0
Secondary accession number(s): B7FAS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health