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Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermus aquaticus Y51MC23
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei84CitrullineUniRule annotation1
Binding sitei114ATP; via amide nitrogenUniRule annotation1
Binding sitei116AspartateUniRule annotation1
Binding sitei120AspartateUniRule annotation1
Binding sitei120CitrullineUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei124CitrullineUniRule annotation1
Binding sitei173CitrullineUniRule annotation1
Binding sitei182CitrullineUniRule annotation1
Binding sitei258CitrullineUniRule annotation1
Binding sitei270CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 14ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
ORF Names:TaqDRAFT_4745Imported
OrganismiThermus aquaticus Y51MC23Imported
Taxonomic identifieri498848 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000005403 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_4745

Structurei

3D structure databases

ProteinModelPortaliB7A935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
KOiK01940
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B7A935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVLAYSGG LDTSIILKWL KETYGAEVIA FTADIGQGEE VEEAREKALK
60 70 80 90 100
TGASKAIALD LKEEFVRDFV FPMMRTAAVY EGYYLLGTAI ARPLIAKYLV
110 120 130 140 150
KIAEEEGAEA IAHGATGKGN DQVRFELTAY ALRPNIRVIA PWREWSFKGR
160 170 180 190 200
QEMIAYAEAH GIPVPVTQEK PYSMDANLLH ISYEGGVLED PWAEPPEGMF
210 220 230 240 250
RMTLDPEKAP DAPEYVEVEF HEGDPVAVNG ERLSPAALLQ RLNEMGGRHG
260 270 280 290 300
VGRVDLVENR FVGMKSRGVY ETPGGTILYH ARRAVESLTL DREVLHQRDM
310 320 330 340 350
LAPKYAELVY YGFWYAPERE ALQAYFDHVA KAVTGVARLK LYKGNVYVVG
360 370 380 390 400
RKAPKSLYQK DLVSFDELGA YDQKDAEGFI KIQALRLRVR ALVEGKGHGA
Length:400
Mass (Da):44,631
Last modified:February 10, 2009 - v1
Checksum:iD914E0545ADF55C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABVK02000006 Genomic DNA Translation: EED10019.1
RefSeqiWP_003047107.1, NZ_CP010822.1

Genome annotation databases

EnsemblBacteriaiEED10019; EED10019; TaqDRAFT_4745
KEGGitaq:TO73_0159

Similar proteinsi

Entry informationi

Entry nameiB7A935_THEAQ
AccessioniPrimary (citable) accession number: B7A935
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: February 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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