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Entry version 58 (18 Sep 2019)
Sequence version 1 (10 Feb 2009)
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Protein

Chromodomain-helicase-DNA-binding protein 1

Gene

CHD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). Required for centromeric localization of CENPA (PubMed:19625449).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi502 – 509ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 1 (EC:3.6.4.12)
Short name:
CHD-1
Alternative name(s):
ATP-dependent helicase CHD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003887711 – 1719Chromodomain-helicase-DNA-binding protein 1Add BLAST1719

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B6ZLK2

PRoteomics IDEntifications database

More...
PRIDEi
B6ZLK2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SAGA complex (By similarity).

Interacts with SSRP1.

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000023555

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B6ZLK2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini268 – 360Chromo 1PROSITE-ProRule annotationAdd BLAST93
Domaini385 – 448Chromo 2PROSITE-ProRule annotationAdd BLAST64
Domaini489 – 659Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini788 – 939Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi610 – 613DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 177Ser-richAdd BLAST173
Compositional biasi959 – 1062Glu-richAdd BLAST104

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0384 Eukaryota
COG0553 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B6ZLK2

Database of Orthologous Groups

More...
OrthoDBi
57339at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B6ZLK2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040793 CDH1_2_SANT_HL1
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR025260 DUF4208
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18375 CDH1_2_SANT_HL1, 1 hit
PF00385 Chromo, 2 hits
PF13907 DUF4208, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM01176 DUF4208, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00598 CHROMO_1, 2 hits
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6ZLK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGHSDEESV RNSSGESRSD DDSGSASGSG SGSSSGSSSD GSSSQSGSSD
60 70 80 90 100
SESGSESGSQ SESESDTSRE KKQVQAKPPK ADGSEFWKSS PSILAVQRSA
110 120 130 140 150
VLKKQQQQQK AASSDSGSEE DSSSSEDSAD DSSSETKKKK HKDEDWQMSG
160 170 180 190 200
SGSVSGTGSD SESEEDGDKS SCEESESDYE PKNKVKSRKP PSRIKPKSGK
210 220 230 240 250
KSTGQKKRQL DSSEEEEDDD EDYDKRGSRR QATVNVSYKE AEETKTDSDD
260 270 280 290 300
LLEVCGEDVP QTEEDEFETI EKFMDSRIGR KGATGASTTI YAVEVDGDPN
310 320 330 340 350
AGFEKSKELG EIQYLIKWKG WSHIHNTWET EETLKQQNVK GMKKLDNYKK
360 370 380 390 400
KDQETKRWLK NASPEDVEYY NCQQELTDDL HKQYQIVERI IAHSNQKSAA
410 420 430 440 450
GYPDYYCKWQ GLPYSECSWE DGALIAKKFQ ARIDEYFSRN QSKTTPFKDC
460 470 480 490 500
KVLKQRPRFV ALKKQPSYIG GHESLELRDY QLNGLNWLAH SWCKGNSCIL
510 520 530 540 550
ADEMGLGKTI QTISFLNYLF HEHQLYGPFL LVVPLSTLTS WQREIQTWAP
560 570 580 590 600
QMNAVVYLGD ITSRNMIRTH EWMHPQTKRL KFNILLTTYE ILLKDKSFLG
610 620 630 640 650
GLNWAFIGVD EAHRLKNDDS LLYKTLIDFK SNHRLLITGT PLQNSLKELW
660 670 680 690 700
SLLHFIMPEK FSSWEDFEEE HGKGREYGYA SLHKELEPFL LRRVKKDVEK
710 720 730 740 750
SLPAKVEQIL RMEMSALQKQ YYKWILTRNY KALSKGSKGS TSGFLNIMME
760 770 780 790 800
LKKCCNHCYL IKPPDDNEFY NKQEALQHLI RSSGKLILLD KLLIRLRERG
810 820 830 840 850
NRVLIFSQMV RMLDILAEYL KYRQFPFQRL DGSIKGELRK QALDHFNAEG
860 870 880 890 900
SEDFCFLLST RAGGLGINLA SADTVVIFDS DWNPQNDLQA QARAHRIGQK
910 920 930 940 950
KQVNIYRLVT KGSVEEDILE RAKKKMVLDH LVIQRMDTTG KTVLHTGSTP
960 970 980 990 1000
SSSTPFNKEE LSAILKFGAE ELFKEPEGEE QEPQEMDIDE ILKRAETREN
1010 1020 1030 1040 1050
EPGPLTVGDE LLSQFKVANF SNMDEDDIEL EPERNSRNWE EIIPESQRRR
1060 1070 1080 1090 1100
IEEEERQKEL EEIYMLPRMR NCAKQISFNG SEGRRSRSRR YSGSDSDSIT
1110 1120 1130 1140 1150
ERKRPKKRGR PRTIPRENIK GFSDAEIRRF IKSYKKFGGP LERLDAVARD
1160 1170 1180 1190 1200
AELVDKSETD LRRLGELVHN GCIKALKDNS SGQERAGGRL GKVKGPTFRI
1210 1220 1230 1240 1250
SGVQVNAKLV ISHEEELAPL HKSIPSDPEE RKRYVIPCHT KAAHFDIDWG
1260 1270 1280 1290 1300
KEDDSNLLVG IYEYGYGSWE MIKMDPDLSL TQKILPDDPD KKPQAKQLQT
1310 1320 1330 1340 1350
RADYLIKLLN KDLARKEAQR LAGAGNSKRR KTRNKKNKMK ASKIKEEIKS
1360 1370 1380 1390 1400
DSSPQPSEKS DEDDDEEDNK VNEIKSENKE KSKKIPLLDT PVHITATSEP
1410 1420 1430 1440 1450
VPISEESEEL DQKTFSVCKE RMRPVKAALK QLDRPEKGLS EREQLEHTRQ
1460 1470 1480 1490 1500
CLIKIGDHIT ECLKEYTNPE QIKQWRKNLW IFVSKFTEFD ARKLHKLYKH
1510 1520 1530 1540 1550
AIKKRQESQQ HNDQNISSNV NTHVIRNPDV ERLKETTNHD DSSRDSYSSD
1560 1570 1580 1590 1600
RHLSQYHDHH KDRHQGDAYK KSDSRKRPYS AFSNGKDHRD WDHYKQDSRY
1610 1620 1630 1640 1650
YSDSKHRKLD DHRSRDHRSN LEGNLKDSRG HSDHRSHSDH RIHSDHRSTS
1660 1670 1680 1690 1700
EYSHHKSSRD YRYHSDWQMD HRASGSGPRS PLDQRSPYGS RSPLGHRSPF
1710
EHSSDHKSTP EHTWSSRKT
Length:1,719
Mass (Da):197,526
Last modified:February 10, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE08417D4D35F5AE5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB465210 mRNA Translation: BAH03306.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB465210 mRNA Translation: BAH03306.1

3D structure databases

SMRiB6ZLK2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023555

Proteomic databases

PaxDbiB6ZLK2
PRIDEiB6ZLK2

Phylogenomic databases

eggNOGiKOG0384 Eukaryota
COG0553 LUCA
InParanoidiB6ZLK2
OrthoDBi57339at2759
PhylomeDBiB6ZLK2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B6ZLK2

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR040793 CDH1_2_SANT_HL1
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR025260 DUF4208
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF18375 CDH1_2_SANT_HL1, 1 hit
PF00385 Chromo, 2 hits
PF13907 DUF4208, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM01176 DUF4208, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 2 hits
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6ZLK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: February 10, 2009
Last modified: September 18, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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