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Protein
Submitted name:

Antitoxin

Gene

pezA_4

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AntitoxinImported
Submitted name:
Antitoxin PezAImported
Submitted name:
Helix-turn-helix domain proteinImported
Submitted name:
PezAImported
Submitted name:
Transcriptional regulatorImported
Submitted name:
XRE family transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pezA_4Imported
Synonyms:pezAImported, pezA_1Imported, pezA_2Imported, pezA_3Imported
ORF Names:A5N45_07925Imported, AZJ10_10840Imported, AZJ17_09815Imported, AZJ18_10580Imported, AZJ19_04965Imported, AZJ80_10730Imported, ERS020474_01415Imported, ERS020526_04974Imported, ERS020534_02374Imported, ERS020692_00226Imported, ERS021218_00914Imported, ERS021218_00917Imported, ERS021762_00584Imported, ERS021762_00653Imported, ERS021762_00656Imported, ERS021762_02670Imported, ERS043879_00721Imported, ERS050646_00490Imported, NTPn46_11070Imported, SAMEA1026615_01199Imported, spr0951Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1313 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000234783 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000044969 Componenti: Unassembled WGS sequence
  • UP000075530 Componenti: Unassembled WGS sequence
  • UP000235048 Componenti: Unassembled WGS sequence
  • UP000235012 Componenti: Unassembled WGS sequence
  • UP000198094 Componenti: Unassembled WGS sequence
  • UP000070772 Componenti: Unassembled WGS sequence
  • UP000235045 Componenti: Unassembled WGS sequence
  • UP000235432 Componenti: Unassembled WGS sequence
  • UP000043837 Componenti: Unassembled WGS sequence
  • UP000040760 Componenti: Unassembled WGS sequence
  • UP000046095 Componenti: Unassembled WGS sequence
  • UP000214939 Componenti: Unassembled WGS sequence
  • UP000234831 Componenti: Unassembled WGS sequence
  • UP000042569 Componenti: Unassembled WGS sequence
  • UP000044836 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 60HTH cro/C1-typeInterPro annotationAdd BLAST55

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41061SY Bacteria
COG1396 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00093 HTH_XRE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035569 Antitoxin_epsilon/PezA_dom_sf
IPR001387 Cro/C1-type_HTH
IPR010982 Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01381 HTH_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00530 HTH_XRE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47413 SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50943 HTH_CROC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6ZCC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGKNIKSLR KTHDLTQPEF ARIIGISRNS LSRYENGTSS VSTELIDIIC
60 70 80 90 100
QKFNVSYVDI VGEDKMLNPV EDYELTLKIE IVKERGANLL SRLYRYQDSQ
110 120 130 140 150
GISIDDESNP WILMSDDLSD LIHTNIYLVE TFDEIERYSG YLDGIERMLE

ISEKRMVA
Length:158
Mass (Da):18,246
Last modified:January 20, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1218465613A6D09A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU351020 Genomic DNA Translation: ACC59271.1
GU808561 Genomic DNA Translation: ADX31251.1
GU808561 Genomic DNA Translation: ADX31263.1
FM201786 Genomic DNA Translation: CAR31459.1
FR670347 Genomic DNA Translation: CBY91948.1
CKRN01000016 Genomic DNA Translation: CIZ06532.1
CMJQ01000011 Genomic DNA Translation: CKA83690.1
CMJQ01000012 Genomic DNA Translation: CKA85994.1
CMJQ01000012 Genomic DNA Translation: CKA86068.1
CMJQ01000198 Genomic DNA Translation: CKB54860.1
CRPE01000002 Genomic DNA Translation: COM90177.1
CRRL01000090 Genomic DNA Translation: COP60710.1
CRSC01000037 Genomic DNA Translation: COQ94545.1
CRVC01000009 Genomic DNA Translation: COR52884.1
CRVC01000009 Genomic DNA Translation: COR52969.1
CNOG02000120 Genomic DNA Translation: CTO25328.1
FIYI01000004 Genomic DNA Translation: CZD73543.1
LJWP01000097 Genomic DNA Translation: KXW41915.1
NNBW01000114 Genomic DNA Translation: OYL27651.1
LTCL01000099 Genomic DNA Translation: PLV76406.1
LTCO01000040 Genomic DNA Translation: PLV83450.1
LTCP01000163 Genomic DNA Translation: PLV85232.1
LTCW01000062 Genomic DNA Translation: PLV93239.1
LTCV01000014 Genomic DNA Translation: PLW03116.1
FYQS01000012 Genomic DNA Translation: SNI94847.1

NCBI Reference Sequences

More...
RefSeqi
WP_000579612.1, NZ_UHGN01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CIZ06532; CIZ06532; ERS020474_01415
CKA83690; CKA83690; ERS021762_00584
CKA85994; CKA85994; ERS021762_00653
CKA86068; CKA86068; ERS021762_00656
CKB54860; CKB54860; ERS021762_02670
CNZ03071; CNZ03071; ERS020873_00834
COM90177; COM90177; ERS020692_00226
COP60710; COP60710; ERS020534_02374
COQ74936; COQ74936; EBG00005157528
COR52884; COR52884; ERS021218_00914
COR52969; COR52969; ERS021218_00917
CRG02248; CRG02248; ERS020526_06288
CTE00963; CTE00963; ERS044129_00731
CTO25328; CTO25328; ERS043879_00721
CWM42762; CWM42762; ERS515182_01839
CZD73543; CZD73543; ERS050646_00490
KXW41915; KXW41915; NTPn46_11070

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1313.6513.peg.1336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU351020 Genomic DNA Translation: ACC59271.1
GU808561 Genomic DNA Translation: ADX31251.1
GU808561 Genomic DNA Translation: ADX31263.1
FM201786 Genomic DNA Translation: CAR31459.1
FR670347 Genomic DNA Translation: CBY91948.1
CKRN01000016 Genomic DNA Translation: CIZ06532.1
CMJQ01000011 Genomic DNA Translation: CKA83690.1
CMJQ01000012 Genomic DNA Translation: CKA85994.1
CMJQ01000012 Genomic DNA Translation: CKA86068.1
CMJQ01000198 Genomic DNA Translation: CKB54860.1
CRPE01000002 Genomic DNA Translation: COM90177.1
CRRL01000090 Genomic DNA Translation: COP60710.1
CRSC01000037 Genomic DNA Translation: COQ94545.1
CRVC01000009 Genomic DNA Translation: COR52884.1
CRVC01000009 Genomic DNA Translation: COR52969.1
CNOG02000120 Genomic DNA Translation: CTO25328.1
FIYI01000004 Genomic DNA Translation: CZD73543.1
LJWP01000097 Genomic DNA Translation: KXW41915.1
NNBW01000114 Genomic DNA Translation: OYL27651.1
LTCL01000099 Genomic DNA Translation: PLV76406.1
LTCO01000040 Genomic DNA Translation: PLV83450.1
LTCP01000163 Genomic DNA Translation: PLV85232.1
LTCW01000062 Genomic DNA Translation: PLV93239.1
LTCV01000014 Genomic DNA Translation: PLW03116.1
FYQS01000012 Genomic DNA Translation: SNI94847.1
RefSeqiWP_000579612.1, NZ_UHGN01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCIZ06532; CIZ06532; ERS020474_01415
CKA83690; CKA83690; ERS021762_00584
CKA85994; CKA85994; ERS021762_00653
CKA86068; CKA86068; ERS021762_00656
CKB54860; CKB54860; ERS021762_02670
CNZ03071; CNZ03071; ERS020873_00834
COM90177; COM90177; ERS020692_00226
COP60710; COP60710; ERS020534_02374
COQ74936; COQ74936; EBG00005157528
COR52884; COR52884; ERS021218_00914
COR52969; COR52969; ERS021218_00917
CRG02248; CRG02248; ERS020526_06288
CTE00963; CTE00963; ERS044129_00731
CTO25328; CTO25328; ERS043879_00721
CWM42762; CWM42762; ERS515182_01839
CZD73543; CZD73543; ERS050646_00490
KXW41915; KXW41915; NTPn46_11070
PATRICifig|1313.6513.peg.1336

Phylogenomic databases

eggNOGiENOG41061SY Bacteria
COG1396 LUCA

Family and domain databases

CDDicd00093 HTH_XRE, 1 hit
Gene3Di1.10.8.130, 1 hit
InterProiView protein in InterPro
IPR035569 Antitoxin_epsilon/PezA_dom_sf
IPR001387 Cro/C1-type_HTH
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF01381 HTH_3, 1 hit
SMARTiView protein in SMART
SM00530 HTH_XRE, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50943 HTH_CROC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6ZCC4_STREE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6ZCC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2009
Last sequence update: January 20, 2009
Last modified: January 16, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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