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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei42Substrate; via amide nitrogenUniRule annotation1
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei176Pyridoxal phosphateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei207Pyridoxal phosphateUniRule annotation1
Binding sitei246Pyridoxal phosphateUniRule annotation1
Binding sitei281Pyridoxal phosphateUniRule annotation1
Binding sitei281SubstrateUniRule annotation1
Binding sitei377SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:CFPG_571
OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
Taxonomic identifieri511995 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
Proteomesi
  • UP000000723 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001868591 – 401LL-diaminopimelate aminotransferaseAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi511995.CFPG_571

Structurei

3D structure databases

ProteinModelPortaliB6YRL2
SMRiB6YRL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2
Regioni235 – 237Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

B6YRL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRINEHYIE ISNSYLFAEI AERVNEYKQN NKNREVISLG IGDVTQAIAP
60 70 80 90 100
AVVEAIHKAT NEMACTKTLR GYAPYEGYDF LIQAILKNDF TDKGISIEAD
110 120 130 140 150
EIFVNDGAKS DTGNIGDILG QDNHIAITDP AYPVYVDTNR MAGRTIELLP
160 170 180 190 200
CTPENYFVPN FPRKTADVIY LCYPNNPTGI ALNAAQLKNW VDYALTNKSL
210 220 230 240 250
ILFDAAYEAY ISQQDVPHSI YEISDAKKVA IEFRSFSKTA GFTGLRAGYT
260 270 280 290 300
IVPKELIIQT SKGKMLSLNA MWRRRQSTKF NGTAYIVQRG AEAVYSIEGQ
310 320 330 340 350
KQIRKAIDYY RGNALTIKEG LESLGVTTYG GINAPYIWVK TPNNLTSWEF
360 370 380 390 400
FDLLLNKIQV IGTPGDGFGQ AGKGFFRFTA FGNKEDTLEA VLRMKKLLEF

H
Length:401
Mass (Da):44,882
Last modified:January 20, 2009 - v1
Checksum:i763EEC12BCC64EFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA Translation: BAG83834.1
RefSeqiWP_012573594.1, NC_011565.1

Genome annotation databases

EnsemblBacteriaiBAG83834; BAG83834; CFPG_571
KEGGiaps:CFPG_571

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA Translation: BAG83834.1
RefSeqiWP_012573594.1, NC_011565.1

3D structure databases

ProteinModelPortaliB6YRL2
SMRiB6YRL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511995.CFPG_571

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG83834; BAG83834; CFPG_571
KEGGiaps:CFPG_571

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_AZOPC
AccessioniPrimary (citable) accession number: B6YRL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 20, 2009
Last modified: October 10, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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