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UniProtKB - B6VEX4 (B6VEX4_HUMAN)
Protein
Submitted name:
Abl interactor 1
Gene
ABI1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein tyrosine kinase activator activity Source: InterPro
GO - Biological processi
- actin polymerization or depolymerization Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Abl interactor 1Submitted name: Abl-interactor 1 variant 21Imported |
Gene namesi | Name:ABI1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11320, ABI1 |
VEuPathDBi | HostDB:ENSG00000136754 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- filopodium ARBA annotation
- lamellipodium ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cell junction Source: UniProtKB-KW
- filopodium Source: UniProtKB-SubCell
- lamellipodium Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junctionARBA annotation, Cell projectionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000136754, Expressed in mouth mucosa and 244 other tissues |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 107 | T-SNARE coiled-coil homologyInterPro annotationAdd BLAST | 63 | |
Domaini | 331 – 390 | SH3InterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 159 – 306 | DisorderedSequence analysisAdd BLAST | 148 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 215 – 261 | Polar residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 262 – 306 | Pro residuesSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the ABI family.ARBA annotation
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154811 |
HOGENOMi | CLU_035421_0_0_1 |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 2 hits PTHR10460:SF2, PTHR10460:SF2, 2 hits |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
B6VEX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET
60 70 80 90 100
KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH
110 120 130 140 150
KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG
160 170 180 190 200
HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPMSGRG TLGRNTPYKT
210 220 230 240 250
LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE
260 270 280 290 300
NSGSSSIGIP IAVPTPSPPT IGPVADSPTP PPPPPPDDIP MFDDSPPPPP
310 320 330 340 350
PPPVDYEDEE AAVVQYNDPY ADGDPAWAPK NYIEKVVAIY DYTKDKDDEL
360 370 380 390
SFMEGAIIYV IKKNDDGWYE GVCNRVTGLF PGNYVESIMH YTD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IZP0 | ABI1_HUMAN | Abl interactor 1 | ABI1 SSH3BP1 | 508 | Annotation score: | ||
A0A0A0MRT6 | A0A0A0MRT6_HUMAN | Abl interactor 1 | ABI1 | 475 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139404 Genomic DNA No translation available. AL390961 Genomic DNA No translation available. FJ380058 mRNA Translation: ACJ12784.1 |
RefSeqi | NP_001171594.1, NM_001178123.1 |
Genome annotation databases
Ensembli | ENST00000536334.5; ENSP00000439646.2; ENSG00000136754.18 |
GeneIDi | 10006 |
UCSCi | uc010qdk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139404 Genomic DNA No translation available. AL390961 Genomic DNA No translation available. FJ380058 mRNA Translation: ACJ12784.1 |
RefSeqi | NP_001171594.1, NM_001178123.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7LXE | X-ray | 1.88 | A | 292-327 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Proteomic databases
ProteomicsDBi | 25653 |
Protocols and materials databases
Antibodypediai | 3646, 352 antibodies from 40 providers |
DNASUi | 10006 |
Genome annotation databases
Ensembli | ENST00000536334.5; ENSP00000439646.2; ENSG00000136754.18 |
GeneIDi | 10006 |
UCSCi | uc010qdk.2, human |
Organism-specific databases
CTDi | 10006 |
HGNCi | HGNC:11320, ABI1 |
OpenTargetsi | ENSG00000136754 |
PharmGKBi | PA36144 |
VEuPathDBi | HostDB:ENSG00000136754 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154811 |
HOGENOMi | CLU_035421_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 10006, 36 hits in 1085 CRISPR screens |
ChiTaRSi | ABI1, human |
GenomeRNAii | 10006 |
Gene expression databases
Bgeei | ENSG00000136754, Expressed in mouth mucosa and 244 other tissues |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 2 hits PTHR10460:SF2, PTHR10460:SF2, 2 hits |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B6VEX4_HUMAN | |
Accessioni | B6VEX4Primary (citable) accession number: B6VEX4 Secondary accession number(s): F5H1G9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 16, 2008 |
Last sequence update: | December 16, 2008 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |