UniProtKB - B6VA23 (2ABB_CARAU)
Protein
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Gene
ppp2r2b
Organism
Carassius auratus (Goldfish)
Status
Functioni
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity
GO - Molecular functioni
- protein phosphatase regulator activity Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAlternative name(s): PP2A subunit B isoform B55-beta PP2A subunit B isoform PR55-beta PP2A subunit B isoform R2-beta PP2A subunit B isoform beta |
Gene namesi | Name:ppp2r2b |
Organismi | Carassius auratus (Goldfish) |
Taxonomic identifieri | 7957 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprininae › Carassius |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Membrane By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- membrane Source: UniProtKB-SubCell
- protein phosphatase type 2A complex Source: InterPro
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000383348 | 1 – 443 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformAdd BLAST | 443 |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 61 | WD 1Add BLAST | 40 | |
Repeati | 87 – 128 | WD 2Add BLAST | 42 | |
Repeati | 171 – 209 | WD 3Add BLAST | 39 | |
Repeati | 220 – 260 | WD 4Add BLAST | 41 | |
Repeati | 279 – 317 | WD 5Add BLAST | 39 | |
Repeati | 334 – 375 | WD 6Add BLAST | 42 | |
Repeati | 410 – 443 | WD 7Add BLAST | 34 |
Sequence similaritiesi
Belongs to the phosphatase 2A regulatory subunit B family.Curated
Keywords - Domaini
Repeat, WD repeatFamily and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit PS00678, WD_REPEATS_1, 1 hit |
i Sequence
Sequence statusi: Complete.
B6VA23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEEIDTRKI NNSFLRDHNY ATEADIISTV EFNPTGELLA TGDKGGRVVV
60 70 80 90 100
FQREQESKSQ PHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPR
110 120 130 140 150
QNAAYFPLST NDKTVKLWKI SERDKRPEGY NLKDEEGRIR DPTTITTLRV
160 170 180 190 200
PVLRPMDLMV EATPRRIFSN AHTYHINSIS VNSDYETYMS TDDLRINLWN
210 220 230 240 250
LEITNRSFNI VDIKPANMEE LTEVITAAEF HPNQCNTFVY SSSKGSIRLC
260 270 280 290 300
DMRTSALCDN HSKLFEEPED PSNRSFFSEI ISSISDVKFS HSGRYLMTRD
310 320 330 340 350
YLTVKVWDIN MESKPLETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGTD
360 370 380 390 400
SVLMTGSYNN FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCIGGKRR
410 420 430 440
KDEISVDSLD FSKKILHTAW HPNENIIAVA ATNNLYIFQD KVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ356012 mRNA Translation: ACJ04071.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ356012 mRNA Translation: ACJ04071.1 |
3D structure databases
SMRi | B6VA23 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit PS00678, WD_REPEATS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABB_CARAU | |
Accessioni | B6VA23Primary (citable) accession number: B6VA23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | December 16, 2008 | |
Last modified: | April 7, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families