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Protein

Conotoxin Im6.1

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Im6.1
Alternative name(s):
Conotoxin 3
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusStephanoconus

Organism-specific databases

ConoServeri3400 Im6.7 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000039272621 – 47CuratedAdd BLAST27
PeptideiPRO_000039272748 – 81Conotoxin Im6.1Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 61By similarity
Disulfide bondi54 ↔ 67By similarity
Disulfide bondi60 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6V6L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLGVVLFT LLLLVPLVTP ERDGGKWTML AKNKKAMKRN LMDFITRTCD
60 70 80
PYYCNDGKVC CPEYPTCGDS TGKLICVRVT D
Length:81
Mass (Da):9,078
Last modified:December 16, 2008 - v1
Checksum:i28459FE1C53D5F7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ237364 mRNA Translation: ACI96055.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ237364 mRNA Translation: ACI96055.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3400 Im6.7 precursor

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM63_CONIM
AccessioniPrimary (citable) accession number: B6V6L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: December 16, 2008
Last modified: October 10, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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