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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei151S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei154UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003705801 – 255tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST255

Proteomic databases

PaxDbiB6SHG7

Expressioni

Gene expression databases

ExpressionAtlasiB6SHG7 differential

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G019597_P01

Structurei

3D structure databases

SMRiB6SHG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 99S-adenosyl-L-methionine bindingUniRule annotation2
Regioni131 – 132S-adenosyl-L-methionine bindingUniRule annotation2
Regioni229 – 231S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3115 Eukaryota
COG0220 LUCA
HOGENOMiHOG000260965
KOiK03439
OMAiIGMEIRV
OrthoDBiEOG09360OC8

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

B6SHG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTNDASGG GKLPRKRFYR ARAHSNPLSD SHFPVPISPE EVDLSQHYPR
60 70 80 90 100
YFPADKGSDG EEAAAPQQIR FADVGCGFGG LLVGLSPLFP DTLMIGMELR
110 120 130 140 150
DKVTEYVKER ILALRGANPG QYDNISVVRT NSMKYIPNYF RKAQLTKMFF
160 170 180 190 200
LFPDPHFKEK NHRRRVISMQ LLDEYAYVME VGGIIYTITD VEELGEWMRS
210 220 230 240 250
CLEKHPLFET VPEEEIKADP VFKLLSTATE ESQKVARNGG QTFYAIFRRI

SLQEE
Length:255
Mass (Da):29,119
Last modified:December 16, 2008 - v1
Checksum:i292FD6EE2F697E22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU952182 mRNA Translation: ACG24300.1
BT066355 mRNA Translation: ACN33252.1
RefSeqiNP_001146900.1, NM_001153428.1
XP_008677164.1, XM_008678942.1
XP_008677165.1, XM_008678943.1
XP_008677166.1, XM_008678944.1
UniGeneiZm.27927

Genome annotation databases

EnsemblPlantsiZm00001d053963_T001; Zm00001d053963_P001; Zm00001d053963
Zm00001d053963_T002; Zm00001d053963_P002; Zm00001d053963
Zm00001d053963_T003; Zm00001d053963_P003; Zm00001d053963
GeneIDi100280508
GrameneiZm00001d053963_T001; Zm00001d053963_P001; Zm00001d053963
Zm00001d053963_T002; Zm00001d053963_P002; Zm00001d053963
Zm00001d053963_T003; Zm00001d053963_P003; Zm00001d053963
KEGGizma:100280508

Similar proteinsi

Entry informationi

Entry nameiTRMB_MAIZE
AccessioniPrimary (citable) accession number: B6SHG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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